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Study Publications

Mexico Childhood Asthma

Mexico Childhood Asthma

The Mexico Childhood Asthma Triad Study generated data that the Epidemiology Branch and its collaborators published in peer-reviewed journal articles. To find out more about the study, please click the following links to journal articles and abstracts.



  1. Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol 2012; Nov 10 pii: S0091-6749(12)01609-0; doi:10.1016/j.jaci.2012.10.002. [Abstract]
  2. Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Celedón JC, Farber HJ, Kumar R, Avila PC, Meade K, Serebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana JR, Borrell LN, Lemanske RF Jr, Bleecker ER, Meyers DA, London SJ, Barnes KC, Raby BA, Martinez FD, Gilliland FD, Williams LK, Burchard EG, Weiss ST, Nicolae DL, Ober C. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol 2012;130(6):1294-301; doi: 10.1016/j.jaci.2012.07.054. [Abstract]
  3. Hancock DB, Romieu I, Chiu GY, Sienra-Monge JJ, Li H, Estela del Rio-Navarro B, London SJ. STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children. Journal of Allergy and Clinical Immunology 2012;129(6):1673-6. [Abstract]


  1. Johnson NA, Coram MA, Shriver MD, Romieu I, Barsh GS, London SJ, Tang H. Ancestral components of admixed genomes in a Mexican cohort. PLoS Genet 2011;7(12):e1002410; doi:10.1371/journal.pgen.1002410. [Abstract]
  2. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley J, Eng C, Stern DA, Celedón JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque WMU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sierra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske Jr. RF, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ, Gilliland FD, Burchard EG, Martinez FD, Weiss ST, Williams LK, Barnes KD, Ober C, and Nicolae DL. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011;43(9):887-92. [Abstract]
  3. Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Rose-Zerilli MJ, Barton SJ, Holgate ST, Kilpatrick JR, Harley JB, Lajoie-Kadoch S, Harley IT, Hamid Q, Kurukulaaratchy RJ, London SJ, Burchard EG, Langefield CD, Wills-Karp M. Identification of ATPAF1 as a novel candidate gene for asthma in children. Journal of Allergy and Clinical Immunology  128(4):753-760.e11, 2011. [Abstract]


  1. Tang H, Siegmund DO, Johnson N, Romieu I, London SJ. Joint testing of genotype and ancestry association in admixed families. Genetic epidemiology. 34(8):783-791, 2010. [Abstract]
  2. Itsara A, Wu H, Smith J, Nickerson DA, Romieu I, London S, Eichler EE. De Novo Rates and Selection of Large Copy Number Variation. Genome research. 20(11):1469-1481, 2010. [Abstract]
  3. Moreno-Macias H, Romieu I, London SJ, Laird NM. Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. Hum Genomics 2010;4(5):302-26. [Abstract]
  4. Romieu I, Moreno-Macias H, London SJ. Gene by environment interaction and ambient air pollution. Proc Am Thorac Soc 2010;7(2):116-22; doi: 10.1513/pats.200909-097RM. [Abstract]


  1. Wu H, Romieu I, Shi M, Hancock DB, Li H, Sienra-Monge JJ, Chiu GY, Xu H, del Rio-Navarro BE, London SJ. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J Allergy Clin Immunol 2010;125(2):321-327. [Abstract]
  2. Hancock DB, Romieu I, Shi M, Sienra-Monge JJ, Wu H, Chiu GY, Li H, del Rio-Navarro BE, Eng C, Chapela R, Burchard EG, Tang H, Sullivan PF, London SJ. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS genetics. 5(8):e1000623, 2009. PMID: 19714205. [Abstract] [Full Text]
  3. Wu H, Romieu I, Sienra-Monge JJ, del Rio-Navarro BE, London SJ. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy. 64(4):629-635, 2009. [Abstract]


  1. Wu H, Romieu I, Sienra-Monge JJ, del Rio-Navarro BE, Burdett L, Yuenger J, Li H, Chanock SJ, London SJ. Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. Genes Immun 2008;9:224-30. Epub 2008 Mar 13.



  1. Li H, Romieu I, Wu H, Sienra-Monge JJ, Ramírez-Aguilar M, del Río-Navarro BE, Lara-Sánchez I, Kistner EO, Gjessing HK, London SJ. Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Human Genetics. Epub Feb 28 2007. [Abstract]
  2. Wu H, Romieu I, Sienra-Monge JJ, Estela del Rio-Navarro BE, Anderson DM, Dunn EW, Steiner LL, Lara-Sanchez Idel C, London SJ. Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma. Environ Health Perspect 2007;115:616-22. Epub 2007 Jan 16.
  3. Wu H, Romieu I, Sienra-Monge JJ, Estela Del Rio-Navarro BE, Anderson DM, Jenchura CA, Li H, Ramirez-Aguilar M, Del Carmen Lara-Sanchez I, London SJ. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. J Allergy Clin Immunol 2007;120:322-8. Epub 2007 Jun 1.


  1. Romieu I, Ramirez-Aguilar M, Sienra-Monge JJ, Moreno-Macias H, Del Rio-Navarro BE, David G, Marzec J, Hernandez-Avila M, London S. GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J. 28(5):953-959, Nov 2006. Epub 2006 Jul 26. [Abstract]


  1. Li H, Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Estela Del Rio-Navarro B, Kistner EO, Gjessing HK, Lara-Sanchez Idel C, Chiu GY, London SJ. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol 2006;117:119-26. Epub 2005 Nov 28. [Abstract]


  1. Romieu I, Sienra-Monge JJ, Ramirez M, Moreno-Macias H, Reyes-Ruiz NI, del Rio-Navarro BE, Hernandez-Avila M, London SJ. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure among Mexico City children. Thorax. 59:8-10, 2004. [Abstract] [Full Text] [Download the PDF]


  1. David GL, Romieu I, Sienra-Monge JJ, Collins WJ, Ramirez-Aguilar M, del Rio-Navarro BE, Reyes-Ruiz NI, Morris R, Marzec JM, London SJ. Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma. Am J Respir Crit Care Med. 168:1199-1204, 2003. [Abstract] [Full Text]

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