Environmental Autoimmunity Group
- Lisa Rider, M.D.
Deputy Chief and Staff Clinician, Environmental Autoimmunity Group
- Tel 301-451-6272
- 10 Center Dr
Hatfield Clinical Research Center
Bethesda, MD 20892-1301
Lisa G. Rider, M.D., is Deputy Chief of the Environmental Autoimmunity Group and Staff Clinician. The mission of the Environmental Autoimmunity Group is to understand the mechanisms for the development of autoimmune diseases so that group members can extend healthy life and reduce the burdens of illness and disability. The group conducts a broad program of clinical, translational, and basic investigations in the area of adult and pediatric autoimmune diseases. Dr. Rider leads the pediatric research studies and pediatric enrollments in the group.
The group uses multidisciplinary approaches to understand the roles of genetic and environmental risk factors for these diseases. Group members are currently focusing investigations on the Systemic Rheumatic Diseases. The diseases Dr. Rider is most involved with in the group’s research studies include the Juvenile Idiopathic Inflammatory Myopathies (Juvenile Dermatomyositis, Juvenile Polymyositis, and related Juvenile Myositis Syndromes), as well as Juvenile Idiopathic Arthritis, Juvenile Systemic Lupus Erythematosus, Juvenile Systemic Sclerosis (Scleroderma). These illnesses are heterogeneous groups of disorders defined by chronic inflammation and are prototypic autoimmune diseases.
The group supports studies at the NIH Clinical Center, which include epidemiologic surveys, molecular genetic studies, clinical investigations in disease pathogenesis, and the development of clinical tools for the assessment of innovative therapies.
Major areas of research:
- Understanding Phenotypes, Genetic and Environmental Risk Factors for Pediatric Autoimmune Diseases, particularly Juvenile Myositis
- Understanding mechanisms for development of pediatric autoimmune diseases, particularly Juvenile Myositis
- Developing new assessments and novel therapies for Juvenile Myositis
- Studies in the Natural History & Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies - An ongoing study enrolling patients with juvenile and adult myositis, healthy volunteers and patients with related diseases. Most patients have been diagnosed with dermatomyositis or polymyositis. The study is examining disease subgroups, genetic and environmental factors for the development of these diseases and for associated illness complications, developing new assessment tools, imaging studies and biomarkers.
Rider oversees trainees in the group, and leads national and international consortia that evaluate and conduct a wide range of basic and clinical studies on juvenile and adult myositis. She obtained her medical degree at the Duke University School of Medicine, completed her residence in pediatrics at Seattle Children’s Hospital of University of Washington, and her fellowship in pediatric rheumatology at Seattle Children’s Hospital, Seattle, WA, Children’s National Medical Center, Washington D.C. and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. Rider has focused much of her work on autoimmune muscle diseases in children, and has received several awards of distinction. She has authored or co-authored more than 150 research publications, reviews, books, and book chapters. She also co-established and is co-chair of the International Myositis Assessment and Clinical Studies Group (IMACS) and the Childhood Myositis Heterogeneity Study Group. Rider leads many pediatric studies in the Myositis Genetics Consortium (MYOGEN) to define new genetic risk and protective factors for myositis and is investigating environmental risk factors for pediatric autoimmune diseases.
Relevance to NIEHS Mission
Our work is helping to identify new genetic and environmental risk and protective factors for myositis and other autoimmune diseases, particularly in children and how these differ from adults. Our goal is to define a number of genetic and environmental risk factors for disease development and to understand the mechanisms involved in initiating illness. Identification of environmental risk factors for disease may lead to preventive strategies to modulate environmental factors to decrease the severity of illness or even prevent its onset.