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Your Environment. Your Health.

Nisha S. Sipes, Ph.D.

Toxicoinformatics Group

Nisha S. Snipes, Ph.D.
Nisha S. Sipes, Ph.D.
Health Science Evaluator
Tel 984-287-3187
P.O. Box 12233
Mail Drop K2-17
Durham, N.C. 27709
Collage of test tubes

Nisha S. Sipes, Ph.D., is a Health Science Evaluator in the Biomolecular Screening Branch of the National Toxicology Program (NTP). Her projects are focused on 1) analyzing and developing computational approaches for the Tox21 high-throughput screening dataset as well as genomics datasets, 2) developing better estimates of in vivo likelihood of exposure, 3) providing input into testing scenarios, and 4) facilitating better public understanding and use of the data. Prior to joining the NTP, Nisha spent 5 years in the National Center for Computational Toxicology at the US EPA where she analyzed ToxCast high-throughput screening data and built computational models of developmental toxicity.

Sipes received a B.S. in mechanical engineering, M.S. in biomedical engineering, and a Ph.D. in cell and molecular biology from the University of Cincinnati, Ohio. She is the Secretary for the Genetics and Environmental Mutagenesis Society (GEMS), a member of the Society of Toxicology and Teratology Society, and serves on the Editorial Board of Reproductive Toxicology.

Selected Publications

  1. Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS (2017). An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library. Environ Sci Technol 51(18):10786-10796. [Abstract]
  2. Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, Setzer RW, Knudsen TB, Crofton KM, Thomas RS (2016). Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor. Toxicol Sci 152(2):323-39. [Abstract]
  3. Pei Y, Peng J, Behl M, Sipes NS, Shockley KR, Rao MS, Tice RR, Zeng X (2016). Comparative Neurotoxicity Screening in Human iPSC-derived Neural Stem Cells, Neurons, and Astrocytes. Brain Res 1638(Pt A):57-73. [Abstract]
  4. Judson R, Houck K, Martin M, Knudsen T, Thomas R, Sipes N, Shah I, Wambaugh J, Crofton K (2014). In Vitro and Modeling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Program. Basic Clin Pharmacol Toxicol 115(1):69-76. [Abstract]
  5. Rotroff DM, Martin MT, Dix DJ, Filer D, Houck KA, Knudsen TB, Sipes NS, Reif DM, Xia M, Huang R, Judson RS (2014). Predictive Endocrine Testing in the 21st Century Using In Vitro Assays of Estrogen Receptor Signaling Responses. Environ Sci Technol 48(15):8706-16. [Abstract]
  6. Wambaugh JF, Setzer W, Pitruzzello AM, Liu J, Reif DM, Kleinstreuer NC, Wang NY, Sipes N, Martin MT, Das K, DeWitt JC, Strynar M, Judson R, Houck KA, Lau C (2013). Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate. Toxicol Sci 136(2):308-327. [Abstract]
  7. Rotroff DM, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Reif DM, Richard AM, Sipes NS, Abassi YA, Jin C, Stampfl M, Judson RS (2013). Real-time growth kinetics measuring hormone mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells. Chem Res Toxicol 26(7):1097-107. [Abstract]
  8. Sipes NS, Martin MT, Kothiya P, Reif DM, Judson RS, Richard AM, Houck KA, Dix DJ, Kavlock RJ, and Knudsen TB (2013). Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol 26(6):878-895. (*Featured on the Cover of Chem Res Toxicol June 2013) [Abstract]
  9. Kleinstreuer N, Dix D, Rountree M, Baker N, Sipes N, Reif D, Spencer R, Knudsen T (2013). A Computational Model Predicting Disruption of Blood Vessel Development. PLoS Comput Biol 9(4): e1002996. doi:10.1371/journal.pcbi.1002996 [Abstract]
  10. Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y (2013). Small-Molecule Inhibitors Targeting G-Protein-Coupled Rho Guanine Nucleotide Exchange Factors. Proc Natl Acad Sci USA 110:3155-60. [Abstract]
  11. Knudsen T, Martin M, Chandler K, Kleinstreuer N, Judson R and Sipes N (2013). Predictive Models and Computational Toxicology. In: Teratogenicity Testing: Methods in Molecular Biology. Edited: P Barrow, Humana Press, New York., 947:343-74. [Abstract]
  12. Dix DJ, Houck KA, Judson RS, Kleinstreuer NC, Knudsen TB, Martin MT, Reif DM, Richard AM, Shah I, Sipes NS, Kavlock RJ (2012). Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity. Toxicol Sci 130(2):440-441. [Abstract]
  13. Kavlock R, Chandler KC, Houck K, Hunter S, Judson R, Kleinstreuer N, Knudsen T, Martin MT, Padilla S, Reif D, Richard AM, Rotroff D, Sipes N, and Dix D (2012). Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management. Chem Res Toxicol 25 (7):1287-302. [Abstract]
  14. Padilla S, Corum D, Padnos B, Hunter DL, Beam A, Houck KA, Sipes N, Kleinstreuer N, Knudsen T, Dix DJ, Reif DM (2012). Zebrafish Developmental Screening of the ToxCast™ Phase I Chemical Library. Reprod Toxicol. 33(2):174-87. [Abstract]
  15. Sipes NS, Martin MT, Reif DM, Kleinstreuer NC, Judson RS, Singh AV, Chandler KJ, Dix DJ, Kavlock RJ, Knudsen TB (2011). Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. Toxicol Sci 124(1):109-27. (*Awarded 2012 Society of Toxicology Best Postdoctoral Publication) [Abstract]
  16. Sipes NS, Padilla S, and Knudsen TB (2011). Zebrafish: as an integrative model for twenty-first century toxicity testing. Birth Defects Res, Part C 93(3):256-67. [Abstract]
  17. Knudsen TB, Houck KA, Sipes NS, Singh AV, Jusdson RS, Martin MT, Weissman A, Kleinstreuer NC, Mortensen HM, Reif DM, Rabinowitz JR, Setzer RW, Richard AM, Dix DJ, and Kavlock RJ (2011). Activity profiles of 309 ToxCastTM chemicals evaluated across 292 biochemical targets. Toxicology 282(1-2):1-15. [Abstract]
  18. Kleinstreuer NC, Judson RS, Reif DM, Sipes NS, Singh AV, Chandler KJ, DeWoskin R, Dix DJ, Kavlock RJ, and Knudsen TB (2011). Environmental impact on vascular development predicted by high-throughput screening. Environ Health Perspect 119(11):1596-603. [Abstract]
  19. Chandler KJ, Barrier M, Jeffay S, Nichols HP, Kleinstreuer NC, Singh AV, Reif DM, Sipes NS, Judson RS, Dix DJ, Kavlock R, Hunter ES 3rd, and Knudsen TB (2011). Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLoS One 6(6):e18540. [Abstract]
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