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Your Environment. Your Health.

Arif Rahman, Ph.D.

Toxicoinformatics Group

Arif Rahman
Arif Rahman, Ph.D.
Fellow — Visiting
Tel 984-287-3135
arif.rahman@nih.gov
P.O. Box 12233
Mail Drop K2-02
Durham, N.C. 27709

Arif Rahman, Ph.D., is a postdoctoral fellow in the Biomolecular Screening Branch (BSB) of the Division of National Toxicology Program (DNTP).

data pulled from Rahman's research

Under the mentorship of Dr. Scott Auerbach (Toxicoinformatics group leader at BSB) and Dr. Brian Berridge (NTP Associate Director), Arif is currently working on a project aimed at mechanistic understanding of pharmaceuticals agents- and environmental chemical-induced cardiovascular (CV) toxicity by utilizing transcriptomics (e.g. microarray, RNA-seq, etc.) data. His primary focus is to build gene coregulation based network to characterize biological landscape of heart in rodent as well as in human upon chemical perturbation. By characterizing this molecular level landscape, Arif will identify unique toxicological trajectories and mechanistic processes associated with specific forms of cardiotoxicity. The findings from his studies will then serve as a basis for evaluating the molecular level veracity of in vitro systems that are being developed to evaluate cardiotoxicity.

Arif received his B.S. in Pharmacy and M.S. in Clinical Pharmacy and Pharmacology from the University of Dhaka, Bangladesh. He earned his Ph.D. in Pharmaceutical Sciences (Major: Pharmacology & Toxicology) from the University of Tennessee Health Sciences Center at Memphis, TN, USA. In his dissertation project, Arif investigated the role of Cytochrome P450 enzymes and extracellular vesicles/exosomes in mediating xenobiotics-induced hepatic and extra-hepatic toxicity.

Selected Publications

  1. Rahman MA, Sinha N, Haque S, Kodidela S, and Kumar S (2019) Plasma exosomes exacerbate alcohol- and acetaminophen- induced toxicity via CYP2E1 pathway. Sci Rep. 2019; 9: 6571. doi: 10.1038/s41598-019-43064-2. [Abstract Rahman MA, Sinha N, Haque S, Kodidela S, and Kumar S (2019) Plasma exosomes exacerbate alcohol- and acetaminophen- induced toxicity via CYP2E1 pathway. Sci Rep. 2019; 9: 6571. doi: 10.1038/s41598-019-43064-2.]
  2. Rahman MA, Patters BJ, Kodidela S, and Kumar S (2019) Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies. J Neuroimmune Pharmacol.doi.org/10.1007/s11481-019-09848-z. [Abstract Rahman MA, Patters BJ, Kodidela S, and Kumar S (2019) Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies. J Neuroimmune Pharmacol.doi.org/10.1007/s11481-019-09848-z.]
  3. Rahman MA, Gong Y, and Kumar S (2018) In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication. Toxicology letters. doi.org/10.1016/j.toxlet.2018.04.023. [Abstract Rahman MA, Gong Y, and Kumar S (2018) In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication. Toxicology letters. doi.org/10.1016/j.toxlet.2018.04.023.]
  4. Rahman MA, Midde NM, Wu X, Li W, and Kumar S (2017) Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors. Pharmacol Res Perspect 5. [Abstract Rahman MA, Midde NM, Wu X, Li W, and Kumar S (2017) Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors. Pharmacol Res Perspect 5.]
  5. Midde NM, Rahman MA, Rathi C, Li J, Meibohm B, Li W, and Kumar S (2016) Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method. PloS one 11:e0149225. [Abstract Midde NM, Rahman MA, Rathi C, Li J, Meibohm B, Li W, and Kumar S (2016) Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method. PloS one 11:e0149225.]
  6. Ranjit S, Midde NM, Sinha N, Patters BJ, Rahman MA, Cory TJ, Rao PS, and Kumar S (2016) Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways. PloS one 11:e0163827. [Abstract Ranjit S, Midde NM, Sinha N, Patters BJ, Rahman MA, Cory TJ, Rao PS, and Kumar S (2016) Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways. PloS one 11:e0163827.]
  7. Kumar S, Sinha N, Gerth KA, Rahman MA, Yallapu MM, and Midde NM (2017) Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications. Biochemical and biophysical research communications 491:675-680. [Abstract Kumar S, Sinha N, Gerth KA, Rahman MA, Yallapu MM, and Midde NM (2017) Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications. Biochemical and biophysical research communications 491:675-680.]
  8. Gong Y, Chowdhury P, Midde NM, Rahman MA, Yallapu M, and Kumar S (2017) Novel elvitegravir nano-formulation approach to suppress the viral load in HIV-infected macrophages. Biochemistry and Biophysics Reports. doi: 10.1016/j.bbrep.2017.10.005 [Abstract Gong Y, Chowdhury P, Midde NM, Rahman MA, Yallapu M, and Kumar S (2017) Novel elvitegravir nano-formulation approach to suppress the viral load in HIV-infected macrophages. Biochemistry and Biophysics Reports. doi: 10.1016/j.bbrep.2017.10.005]

Book Chapter

  1. Haque S, Gong Y, Kodidela S, Rahman MA, Ranjit S, Kumar S. Cytochrome P450 Enzymes for the Synthesis of Novel and Known Drugs and Drug Metabolites. In: Pharmaceutical Biocatalysis. 1 ed. Grunwald P, editor. USA: Jenny Stanford Publishing; 2019. Chapter 14; p.34. 774p.
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