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Your Environment. Your Health.

Sreenivasa C. Ramaiahgari, Ph.D.

Molecular Toxicology & Genomics Group

Sreenivasa Ramaiahgari, Ph.D.
Sreenivasa Ramaiahgari, Ph.D.
Staff Scientist
Tel 984-287-3173
sreenivasa.ramaiahgari@nih.gov
111 Tw Alexander Dr
Research Triangle Park, NC 27709

In his current role Ramaiahgari is involved in development and validation of metabolically competent and physiologically relevant in vitro models for high-throughput toxicology studies. Ramaiahgari has extensive experience working with various organotypic in vitro models of liver, kidney, breast and prostate cancer cell types. Ramaiahgari will use these advanced models and apply novel methodologies including high content imaging and data-rich toxicogenomic approaches, e.g. Tox21 human sentinel 1500+ gene expression to study dynamic cellular stress responses upon environmental chemical exposure and extrapolate their effects on human health and disease. Ramaiahgari also contributes to several NTP in vitro screening assays.

Ramaiahgari obtained his B.S. in Biotechnology from Bangalore University, Bangalore, India followed by M.S. in Biotechnology from University of Abertay Dundee, Scotland, UK and a Ph.D. in Toxicology from Leiden University, Netherlands.

Selected Publications

  1. Gwinn WM, Auerbach SS, Parham, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari SC, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. (2020) Evaluation of 5-day in vivo rat liver and kidney with high-throughput transcriptomics for estimating benchmark doses of apical outcomes. Toxicological Sciences. [Abstract Gwinn WM, Auerbach SS, Parham, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari SC, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. (2020) Evaluation of 5-day in vivo rat liver and kidney with high-throughput transcriptomics for estimating benchmark doses of apical outcomes. Toxicological Sciences.]
  2. Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV. (2019) Evaluating sufficient similarity of botanical dietary supplements: Combining chemical and in vitro biological data. Toxicological Sciences. [Abstract Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV. (2019) Evaluating sufficient similarity of botanical dietary supplements: Combining chemical and in vitro biological data. Toxicological Sciences.]
  3. Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS. (2019) The power of resolution: Contextualized understanding of biological responses to liver injury chemicals using high-throughput transcriptomics and benchmark concentration modeling. Toxicological Sciences Jun 1;169(2):553-566. [Abstract Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS. (2019) The power of resolution: Contextualized understanding of biological responses to liver injury chemicals using high-throughput transcriptomics and benchmark concentration modeling. Toxicological Sciences Jun 1;169(2):553-566.]
  4. Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B. (2019) High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. Archives of Toxicology Oct. 93(10):2895-2911. [Abstract Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B. (2019) High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. Archives of Toxicology Oct. 93(10):2895-2911.]
  5. Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS. (2017) Three-dimensional (3D) hepaRG spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity screening. Toxicological Sciences 160, 189-190. [Abstract Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS. (2017) Three-dimensional (3D) hepaRG spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity screening. Toxicological Sciences 160, 189-190.]
  6. Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water, Price LS. (2014) A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Arch Toxicol 88: 1083-1095. [Abstract Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water, Price LS. (2014) A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Arch Toxicol 88: 1083-1095.]
  7. Stokman G, Qin Y, Booij TH, Ramaiahgari SC, Lacombe M, et al. (2014) Epac-Rap signaling reduces oxidative stress in the tubular epithelium. J Am Soc Nephrol 25: 1474-1485. [Abstract Stokman G, Qin Y, Booij TH, Ramaiahgari SC, Lacombe M, et al. (2014) Epac-Rap signaling reduces oxidative stress in the tubular epithelium. J Am Soc Nephrol 25: 1474-1485.]
  8. Benedetti G, Ramaiahgaris SC, Herpers B, van de Water B, Price LS, de Graauw M. (2013) A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-alpha. Toxicol In Vitro 27: 2264-2272. [Abstract Benedetti G, Ramaiahgaris SC, Herpers B, van de Water B, Price LS, de Graauw M. (2013) A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-alpha. Toxicol In Vitro 27: 2264-2272.]
  9. Qin Y, Stokman G, Yan K, Ramaiahgari SC, Verbeek F, et al. (2012) cAMP signaling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac. Br J Pharmacol 165: 1137-1150. [Abstract Qin Y, Stokman G, Yan K, Ramaiahgari SC, Verbeek F, et al. (2012) cAMP signaling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac. Br J Pharmacol 165: 1137-1150.]
  10. Zhang Y, Moerkens M, Ramaiahgari SC, de Bont H, Price L, Meerman J, van de Water B. (2011) Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res 13: R52. [Abstract Zhang Y, Moerkens M, Ramaiahgari SC, de Bont H, Price L, Meerman J, van de Water B. (2011) Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res 13: R52.]

Book chapter:

  1. Ramaiahgari SC, et al. (2014) Hepatotoxicity screening on in vitro models and role of ‘Omics. Toxicogenomics based Cellular Models. Pages. 193-212. [Abstract Ramaiahgari SC, et al. (2014) Hepatotoxicity screening on in vitro models and role of ‘Omics. Toxicogenomics based Cellular Models. Pages. 193-212.]
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