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Your Environment. Your Health.

Sreenivasa C. Ramaiahgari, Ph.D.

Molecular Toxicology & Genomics Group

Sreenivasa Ramaiahgari, Ph.D.
Sreenivasa Ramaiahgari, Ph.D.
Fellow — IRTA Postdoctoral
Tel 984-287-3173
sreenivasa.ramaiahgari@nih.gov
P.O. Box 12233
Mail Drop E1-05
Durham, N.C. 27709

Sreenivasa C. Ramaiahgari is a postdoctoral fellow (2014 to present) in the Molecular Toxicology and Genomics Group within the Biomolecular Screening Branch of National Toxicology Program (NTP).

In his current role Ramaiahgari is involved in development and validation of metabolically competent and physiologically relevant in vitro models for high-throughput toxicology studies. Ramaiahgari has extensive experience working with various three-dimensional cell culture models of liver, kidney, breast and prostate cancer cell types. Ramaiahgari will use these advanced in vitro models and apply novel methodologies including high content imaging and data-rich toxicogenomic approaches, e.g. Tox21 human sentinel 1500+ gene expression to study dynamic cellular stress responses upon environmental chemical exposure and extrapolate their effects on human health and disease. Ramaiahgari also contributes to several NTP in vitro screening assays.

Ramaiahgari obtained his B.S. in Biotechnology from Bangalore University, Bangalore, India followed by M.S. in Biotechnology from University of Abertay Dundee, Scotland, UK and a Ph.D. in Toxicology from Leiden University, Netherlands.

Selected Publications

  1. Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, et al. (2014) A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Arch Toxicol 88: 1083-1095. [Abstract]
  2. Benedetti G*, Ramaiahgaris SC*, Herpers B, van de Water B, Price LS, et al. (2013) A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-alpha. Toxicol In Vitro 27: 2264-2272. (*Both authors contributed equally) [Abstract]
  3. Stokman G, Qin Y, Booij TH, Ramaiahgari SC, Lacombe M, et al. (2014) Epac-Rap signaling reduces oxidative stress in the tubular epithelium. J Am Soc Nephrol 25: 1474-1485. [Abstract]
  4. Zhang Y, Moerkens M, Ramaiahgari SC, de Bont H, Price L, et al. (2011) Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res 13: R52. [Abstract]
  5. Qin Y, Stokman G, Yan K, Ramaiahgari SC, Verbeek F, et al. (2012) cAMP signaling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac. Br J Pharmacol 165: 1137-1150. [Abstract]

Book chapter:

  1. Ramaiahgari SC, et al. (2014) Hepatotoxicity screening on in vitro models and role of ‘Omics. Toxicogenomics based Cellular Models. Pages. 193-212. [Abstract]
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