Biomolecular Screening Branch
- Stephanie L. Smith-Roe, Ph.D.
Biomolecular Screening Branch
Genetic Toxicology Group
- Tel 984-287-3189
- P.O. Box 12233Mail Drop K2-17Durham, N.C. 27709
Stephanie L. Smith-Roe, Ph.D., is a genetic toxicologist in the Genetic Toxicology Group within the Biomolecular Screening Branch (BSB) of the National Toxicology Program (NTP).
Smith-Roe designs experiments to evaluate the genotoxic potential of chemicals, and provides genetic toxicology test data review and evaluation for inclusion in the NTP Technical Reports. She assists with management of the NTP's genetic toxicology testing contract, while also contributing to assay selection, design, and analysis for the NTP initiative for High Throughput Screening (Tox21 Collaboration).
After obtaining a B.S. in Zoology and Psychology (specializing in biochemistry and neuroscience) from the University of Wisconsin-Madison, Smith-Roe received her Ph.D. in Environmental and Molecular Toxicology from Oregon State University. Upon completion of her graduate work, she held a postdoctoral fellowship in the Curriculum in Toxicology at the University of North Carolina at Chapel Hill. She has conducted research in the areas of carcinogenesis, DNA replication, DNA repair, DNA damage signaling, checkpoint signaling, and chromatin remodeling using mouse models and molecular approaches.
Smith-Roe is active in national and local societies dedicated to research and issues related to understanding the causes and consequences of genomic instability. She is a member of the Environmental Mutagenesis and Genomics Society (EMGS), where she has co-chaired several symposia, served as a Councilor, held an appointment as a Councilor Liaison to the Executive Board, and co-chaired or served on numerous committees and task forces. Presently, she is the Chair for the EMGS New Technologies Special Interest Group. She is also a Past President of the Genetics and Environmental Mutagenesis Society (GEMS), headquartered in the Research Triangle Park, NC.
Currently, Smith-Roe is an Editorial Board member of Mutation Research - Genetic Toxicology and Environmental Mutagenesis. She also recently contributed as a Working Group member to the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 121.
- Catlin NR, Collins BJ, Auerbach SS, Ferguson SS, Harnly JM, Gennings C, Waidyanatha S, Rice GE, Smith-Roe SL, Witt KL, Rider CV. How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract. Food Chem Toxicol. 2018 May 9 [Epub ahead of print] [Abstract]
- Kogevinas M, Gwinn WM, Kriebel D, Phillips DH, Sim M, Bertke SJ, Calaf GM, Colosio C, Fritz JM, Fukushima S, Hemminki K, Jensen AA, Kolstad H, Mráz J, Nesnow S, Nylander-French LA, Parent ME, Sandy M, Smith-Roe SL, Stoner G, Suzuki T, Teixeira JP, Vodicka P, Tornero-Velez R, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Vilahur N, Driscoll T, Hall A, Middleton D, Jaillet C, Mattock H, Straif K. Carcinogenicity of quinoline, styrene, and styrene-7,8-oxide. Lancet Oncol. 2018 Apr 18 [Epub ahead of print] [Abstract]
- Smith-Roe SL, Swartz CD, Shepard KG, Bryce SM, Dertinger SD, Waidyanatha S, Kissling GE, Auerbach SS, Witt KL. Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells. Environ Mol Mutagen 2018 [Epub ahead of print] [Abstract]
- Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW. Next generation high throughput DNA damage detection platform for genotoxic compound screening. Sci Rep. 2018;8(1):2771. [Abstract]
- Bryce SM, Bernacki DT, Smith-Roe SL, Witt KL, Bemis JC, Dertinger SD. Investigating the Generalizability of the MultiFlow® DNA Damage Assay. Toxicol Sci 2017 [Epub ahead of print] [Abstract]
- Witt KL, Hsieh JH, Smith-Roe SL, Xia M, Huang R, Zhao J, Auerbach SS, Hur J, Tice RR. Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation. Environ Mol Mutagen 2017 (Epub ahead of print). [Abstract]
- Bower JJ, Vance LD, Psioda M, Smith-Roe SL, Simpson DA, Ibrahim JG, Hoadley KA, Perou CM, Kaufmann WK. Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells. NPJ Breast Cancer 2017 3:9. [Abstract]
- Nishihara K, Huang R, Zhao J, Shahane SA, Witt KL, Smith-Roe SL, Tice RR, Takeda S, Xia M. Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform. Mutagenesis 2016 31(1):69-81.
- Hong HH, Hoenerhoff MJ, Ton TV, Herbert RA, Kissling GE, Hooth MJ, Behl M, Witt KL, Smith-Roe SL, Sills RC, Pandiri AR7. Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Toxicologic pathology 2015 43(6):872-882. [Abstract]
- Smith-Roe SL, Nakamura J, Holley D, Chastain PD 2nd, Rosson GB, Simpson DA, Ridpath JR, Kaufman DG, Kaufmann WK, Bultman SJ. SWI/SNF complexes are required for full activation of the DNA-damage response. Oncotarget 2015 6(2):732-745. [Abstract]
- Wilson TE, Demarini DM, Dertinger SD, Engelward BP, Hanawalt PC, Macgregor JT, Smith-Roe SL, Witt KL, Yauk CL, Ljungman M, Schwartz JL, Klein CB. 2013. Building on the past, shaping the future: The environmental mutagenesis and genomics society. Environ Mol Mutagen, 54(3):153-7. [Abstract]
- Smith-Roe SL & Bultman, SJ. 2013. Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development. Mammalian Genome, 24(1-2):21-29. [Abstract]
- Smith-Roe SL, Patel SP, Zhou YC, Simpson DA, Rao S, Ibrahim J, Cordeiro-Stone M, Kaufmann WK. 2013. Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts. Cell Cycle, 12(2):332-345. [Abstract]
- Yang Y, Durando M, Smith-Roe SL, Sproul C, Greenwalt AM, Kaufmann WK, Oh S, Hendrickson EA, Vaziri C. 2013. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Research, 41(4):2296-2312. [Abstract]
- Smith-Roe SL, Patel SP, Simpson DA, Zhou YC, Rao S, Ibrahim JG, Kaiser-Rogers KA, Cordeiro-Stone M, Kaufmann WK. 2011. Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts. Cell Cycle, 10(10):1618 - 1624. [Abstract]
- Gaddameedhi S, Kemp MG, Reardon JT, Shields JM, Smith-Roe SL, Kaufmann WK, Sancar A. 2010. Similar nucleotide excision repair capacity in melanocytes and melanoma cells. Cancer Research, 70(12):4922-30. [Abstract]
- Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang T, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kacmaz K. 2010. Tipin-RPA interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. Journal of Biological Chemistry, 285(22):16562-16571. [Abstract]
- Smith-Roe SL, Loehr CV, Bildfell RJ, Fischer KA, Hegan DC, Glazer PM, Buermeyer AB. 2006. Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Cancer Letters, 244(1):79-85. [Abstract]
- Smith-Roe SL, Hegan DC, Glazer PM, Buermeyer AB. 2006. Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Mutation Research, 594(1-2):101-112. [Abstract]