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Your Environment. Your Health.

Selected Publications

Genetic Toxicology Group

  1. Nishihara K, Huang R, Zhao J, Shahane SA, Witt KL, Smith-Roe SL, Tice RR, Takeda S, Xia M. (2016) Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a high throughput screening platform. Mutagenesis 31(1):69-81. [Abstract]
  2. Chen S, Hsieh J-H, Huang R, Sakamuru S, Hsin L-Y, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR. (2015) Cell-based high-throughput screening for aromatase inhibitors in the Tox21 10K library. Toxicol. Sci. 147(2):446-57. [Abstract]
  3. French JE, Gati DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, Pedersen LC, Munger SC, Svenson KL, Churchill GA. (2015) Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity. Environ. Health Perspect. 123:237-245. [Abstract]
  4. Gollapudi BB, Lynch AM, Heflich RH, Dertinger SD, Dobrovolsky VN, Froetschl R, Horibata K, Kenyon MO, Kimoto T, Lovell DP, Stankowski LF, White PA, Witt KL, Tanir JY. (2015) The in vivo Pig-a mutant phenotype assay: a report of the International Workshop on Genotoxicity Testing (IWGT) Workgroup. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 783:23-35. [Abstract]
  5. Zeiger E, Gollapudi B, Aardema M, Auerbah S, Boverhof D, Custer L, Dedon P, Honma M, Ishida S, Kasinski A, Kim JH, Manjanatha M, Marlowe J, Pfuhler S, Pogribny I, Slikker W, Stankowski LF, Tanir J, Tice RR, van Benthem J, White P, Witt KL, Thybaud V. (2015) Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report. Environ. Mol. Mutagen. 56:277-285. [Abstract]
  6. Hobbs CA, Recio L, Streicker M, Boyle MH, Tanaka J, Shiga A, Witt KL. (2015) Comet assay evaluation of six chemicals of known genotoxic potential in rats. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 786-788:172-81. [Abstract]
  7. Masaoka A, Gassman NR, Horton JK, Kedar PS, Witt KL, Hobbs CA, Kissling GE, Tano K, Asagoshi K, Wilson SH. Functional and physical interaction between DNA polymerase β and BRCA1. (2013) PLoS One. 8:e66801. [Abstract]
  8. Mercado-Feliciano M, Cora MC, Witt KL, Granville CA, Hejtmancik MR, Fomby L, Knostman KA, Ryan MJ, Newbold R, Smith C, Foster PM, Vallant MK, Stout MD. (2012) An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents. Toxicol. Appl. Pharmacol. 263:138-147. [Abstract]
  9. Recio L, Kissling GE, Hobbs C, Witt KL. (2012) Comparison of comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues. Environ. Mol. Mutagen. 53:101-113. [Abstract]
  10. Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR. (2011) Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ. Mol. Mutagen. 52:547-561. [Abstract]
  11. Witt KL, Malarkey D, Hobbs CA, Davis J, Kissling GE, Caspary W, Recio L. (2010) Evaluation of micronucleus frequencies and DNA damage in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ. Mol. Mutagen. 51:80-88. [Abstract]
  12. Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Malarkey DE, Hooth MJ. (2009) Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environmental health perspectives 117(5):716-722. [Abstract]
  13. Witt KL, Shelby MD, Itchon-Ramos N, Faircloth M, Kissling GE, Chrisman AK, Ravi H, Murli H, Mattison DR, Kollins SH. (2008) Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. J Am Acad Child Adolesc Psychiatry. 47(12):1375-83. [Abstract]  
  14. Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. (2008) Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect. 116(3):284-91. [Abstract]  
  15. Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. (2008) Comparison of flow cytometry and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutation Res. 649(1-2):101-113. [Abstract]  
  16. Witt KL,Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB. (2007) Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environ Mol Mutagen. 48:322-329. [Abstract]