Biostatistics & Computational Biology Branch
Examples of ongoing projects include:
Two Sister Study: Funding secured through Susan G. Komen for the Cure made it possible to carry out a family-based study of young-onset breast cancer (PI, Weinberg) built on the cohort recruited for the Sister Study (PI, Sandler, EB). This study includes a woman who had been diagnosed with breast cancer under age 50 and her control sister who was participating in the Sister Study cohort. Available parents provided DNA samples through mail-back saliva collection kits, and genotyping enabled a genome-wide assessment of genetic variants related to the risk of young-onset breast cancer. We will also be seeking to identify composite factors that promote healthy survival following treatment. Statistical methods developed in the branch enabled a robust analysis that allows estimation of exposure effects and multiplicative gene-by-environment interaction effects. More than 1500 families were enrolled.