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Dmitri Zaykin, Ph.D.

Biostatistics Branch

Dmitri Zaykin, Ph.D.
Dmitri Zaykin, Ph.D.
Principal Investigator
Tel (919) 541-0096
Fax (919) 541-4311
zaykind@niehs.nih.gov
P.O. Box 12233
Mail Drop A3-03
Research Triangle Park, North Carolina 27709
Delivery Instructions

Research Summary

Dmitri Zaykin joined the Biostatistics Branch at NIEHS in October 2004. His previous positions in statistical and population genetics were at the Institute of Marine Biology in Vladivostok, Russia, North Carolina State University’s Statistics Department and at GlaxoSmithKline Inc. His scientific interests are in the areas of statistical, population genetics and genetic epidemiology with applications to genetics of human diseases and pharmacogenetics. His research focus is on:

 

  • Approaches for simultaneous association analysis of multiple polymorphisms with human traits such as disease predisposition and adverse reactions to drugs
  • Multilocus association methods when the haplotype phase is unobserved
  • Statistical methods for estimation of genetic susceptibility
  • Population-genetic aspects of effective population size
  • Studies of genetic associations in the presence of population heterogeneity
  • Characterizing disequilibria within and between multiple genetic loci with applications to studies of population structure and forensics
  • Properties and estimation of two-locus disequilibria
  • Haplotype and linkage disequilibrium based marker selection methods for large-scale association studies and other issues of selecting polymorphisms that tag common haplotypic variation in human populations
  • Meta-analysis methods in the presence of effect size heterogeneity, "file drawer effects" and other sources of publication bias
  • Multiple-testing problems in genome scans
  • Relative distributions of true and false discoveries and false discovery rates

 

Software

The following links send you to new web pages where files are available for downloading. Once you arrive at the new web pages, to download a file, either RIGHT CLICK (on a PC) or CONTROL CLICK (on a Mac) and pick Download Link To Disk (sometimes listed as Save Link to Disk). Additional downloads at the Biostatistics software page ("/Rhythmyx/assembler/render?sys_contentid=56373&sys_revision=6&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56373" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56373" sys_siteid="" sys_folderid="").

 

  • Analysis of Genetic Associations for Shared Controls Design
    ("/Rhythmyx/assembler/render?sys_contentid=35154&sys_revision=8&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35154" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35154" sys_siteid="" sys_folderid="")P-value based analysis for shared controls design in genome-wide association studies.
  • Correlation-Based Tests
    ("/Rhythmyx/assembler/render?sys_contentid=35146&sys_revision=5&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35146" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35146" sys_siteid="" sys_folderid="")Correlation-based inference for linkage disequilibrium with multiple alleles.
  • "The program "Haplotype Trend Regression"  
    Developed while at North Carolina State University.
  • Rankings of causal loci in GWAS
    ("/Rhythmyx/assembler/render?sys_contentid=35144&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35144" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35144" sys_siteid="" sys_folderid="")Novel rank-based approaches for discovery and replication in genome wide association studies.

 

Selected Publications

  1. Shi M, London SJ, Chiu GY, Hancock DB, Zaykin D, Weinberg CR. 2011. Using imputed genotypes for relative risk estimation in case-parent studies. American Journal of Epidemiology 173(5): 553-559. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21296892?dopt=Abstract) ]  
  2. Kuo C-L, Zaykin DV. 2011. Novel rank-based approaches for discovery and replication in genome wide association studies. Genetics [Epub ahead of print]. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21705758) ]  
  3. Zaykin DV. 2011. Optimally weighted Z-test is a powerful method for combining probabilities in meta-analysis. J Evol Biol 24: 836-841. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21605215) ]  
  4. Yellaboina S, Tasneem A, Zaykin DV, Raghavachari B, Jothi R. 2011. DOMINE: a comprehensive collection of known and predicted domain-domain interactions. Nucleic Acids Res 39: 730-735. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21113022) ]  
  5. Zaykin DV, Kozbur DO. 2010. P-value based analysis for shared controls design in genome-wide association studies. Genet Epidemiol 34: 725-738. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20976797) ]  
  6. Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, et al. 2010. Multiple chronic pain states are associated with a common amino acid changing allele in KCNS1. Brain 133: 2519-2527. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20724292) ]  
  7. Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin D, McHale DP, Drenth JPH et al. 2010. Pain perception is altered by a nucleotide polymorphism in SCN9A. PNAS 107: 5148-5153. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20212137) ]  
  8. Shabalina SA, Zaykin DV, Gris P, Ogurtsov AY, Gauthier J, Shibata K, Tchivileva IE, Belfer I, Mishra B, Kiselycznyk C, Wallace MR, Staud R, Spiridonov NA, Max MB, Goldman D, Fillingim RB, Maixner W, Diatchenko L. 2009. Expansion of the human mu-opioid receptor gene architecture: novel functional variants. Hum Mol Genet 18: 1037-1051. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19103668) ]  
  9. Zheng G, Joo J, Zaykin DV, Wu CO, Geller NL. 2009. Robust tests in genome-wide scans under incomplete linkage disequilibrium. Statistical Science 24: 503-516. [Abstract (http://arxiv.org/abs/1010.5091) ]  
  10. Sayenko EM, Bogatov VV, Zaykin DV. 2009. On the systematic position of the Far Eastern Kunashiria and Arsenievinaia genera (Bivalvia, Unionidae). Russian Journal of Zoology 88: 1298-1310. [Abstract (http://cat.inist.fr/?aModele=afficheN&cpsidt=22381707) ]  
  11. Zaykin DV, Pudovkin AI, Weir BS. 2008. Correlation-based inference for linkage disequilibrium with multiple alleles. Genetics 180: 533-545. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18757931) ]  
  12. Shibata K, Diatchenko L, Zaykin DV. 2008. Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. Genet Epidemiol 33: 63-78. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18636529) ]  
  13. Zaykin DV, Shibata K. 2008. Genetic flip-flop without an accompanying change in linkage disequilibrium. Am J Hum Genet 82: 794-796.  
  14. Menzorov AG, Matveeva NM, Larkin DM, Zaykin DV, Serov OL. 2008. Fate of parental mitochondria in embryonic stem hybrid cells. Cell and Tissue Biology 2: 393-399.  
  15. Zaykin DV, Zhivotovsky LA, Czika W, Shao S, Wolfinger RD. 2007. Combining p-values in large scale genetics experiments. Pharmaceutical Statistics 6(3): 217-226. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17879330?dopt=Abstract) ]  
  16. Warren LL, Hughes AR, Lai EH, Zaykin DV, Haneline SA, Bansal AT, Wooster AW, Spreen WR, Hernandez JE, Scott TR, Roses AD, Mosteller M. 2006. Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan. Pharmacogenomics J. Sep 12 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16969363?dopt=Abstract) ]  
  17. Zaykin DV, Meng Z, Ehm MG. 2006. Contrasting  linkage disequilibrium patterns between cases and controls as a novel association mapping method. Am J Hum Genet 78: 737-746. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16642430?dopt=Abstract) ]  
  18. Zaykin DV, Zhivotovsky L. 2005. Ranks of genuine associations in whole genome scans. Genetics 171: 813-823. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16020784?dopt=Abstract) ]  
  19. Zaykin DV, Young SS. 2005. Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations. Pharmacogenomics 6: 77-89. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15723608?dopt=Abstract) ]  
  20. Nielsen DM, Ehm MG, Zaykin DV, Weir BS. 2004. Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations. Genetics 168: 1029-1040. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15514073?dopt=Abstract) ]  
  21. Zaykin DV. 2004. Bounds and normalization of the composite linkage disequilibrium coefficient. Genetic Epidemiology 27: 252-257. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15389931?dopt=Abstract) ]  
  22. Zaykin DV, Meng Z, Ghosh SK. 2004. Interval estimation of genetic susceptibility for retrospective case-control studies. BMC Genetics May 11; 5(1): 9. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15137913?dopt=Abstract) ]  
  23. Meng Z, Zaykin DV, Xu C-F, Wagner M, Ehm M. 2003. Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes. Am J of Hum Genet 73: 115-130. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/12796855?dopt=Abstract) ]  
  24. Zaykin DV, Westfall PH, Young SS, Karnoub MC, Wagner MJ, Ehm MG. 2002. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Human Heredity 53: 79–91. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/12037407?dopt=Abstract) ]  
  25. Zaykin DV, Zhivotovsky LA, Westfall PH, and Weir BS. 2002. Truncated product method for combining p-values. Genetic Epidemiology 22: 170-185. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11788962?dopt=Abstract) ]  
  26. Xu C-F, Lewis K, Cantone CL, Khan P, Donnelly C, White N, Crocker N, Boyd PR, Zaykin DV, Purvis IJ. 2002. Effectiveness of computational methods in haplotype prediction. Hum Genet 110: 148-156. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11935321?dopt=Abstract) ]  
  27. Westfall PH, Zaykin DV, and Young SS. 2001. Multiple tests for genetic effects in association studies.  In "Biostatistics Methods", series "Methods in Molecular Biology, Biotechnology and Medicine", Stephen Looney, Ed., The Humana Press, Inc.  
  28. Nielsen DM, Zaykin DV. 2001. Association mapping: where we’ve been, where we’re going. Expert Reviews in Molecular Diagnostics 1: 334-42. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11901839?dopt=Abstract) ]  
  29. Meng Z, Zaykin DV, Karnoub MC, Sreekumar GP, St Jean PL, Ehm MG. 2001. Identifying susceptibility genes using linkage and linkage disequilibrium analysis in large pedigrees. Genetic Epidemiology 21S: 453-458. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11793718?dopt=Abstract) ]  
  30. Almasy L, Terwilliger JD, Nielsen D, Dyer TD, Zaykin D, Blangero J. 2001. GAW12: Simulated genome scan, sequence, and family data for a common disease. Genetic Epidemiology 21S: 332-338. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11793693?dopt=Abstract) ]  
  31. Thomas DC, Borecki IB, Thomson G, Weiss K, Terwilliger JD, Nielsen D, Zaykin D, Blangero J, Almasy L, Macluer J. 2001. Abstract. Evolution of the simulated data problem. Genetic Epidemiology 21S: 325-331. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11793692?dopt=Abstract) ]  
  32. Zaykin DV, Young SS, and Westfall PH. 2000. Using false discovery rate approach in the genetic dissection of complex traits: a response to Weller et al. Genetics 154: 1917-1918. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10950641?dopt=Abstract) ]  
  33. Zaykin D and Pudovkin A. 2000. The variance effective population size for mitochondrial genes. Russian Journal of Genetics 36: 965-967.  
  34. Nielsen D, Zaykin D. 1999. Novel tests for marker-disease association using the Collaborative Study on the Genetics of Alcoholism data. Genetic Epidemiology S265-S270. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10597447?dopt=Abstract) ]
  35. Pudovkin AI, Zaykin D, and Dolganov S. 1998. Interlocus genotypic associations in Sea of Japan settlements of the scallop Mizuhopecten (Patinopecten) yessoensis. Russian Journal of Genetics 34:2 99-305  
  36. Pudovkin AI, Zaykin D, and Hedgecock D. 1996. On the potential for estimating the effective number of breeders from heterozygote-excess in progeny. Genetics 144: 383-387. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8878701?dopt=Abstract) ]  
  37. Pudovkin AI, Zaikin D, and Tatarenkov AH. 1996. A computer program for calculation of genetic distances and their bootstrap confidence intervals. Russian Journal of Genetics 32: 1017-1020.  
  38. Zaykin D, Zhivotovsky LA, and Weir BS, 1995. Exact test for association between alleles at arbitrary number of loci. Genetica 96: 169-178. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/7607454?dopt=Abstract) ]  
  39. Surmach SG and Zaykin DV. 1994. The scaly-sided merganser Mergus squamatus (Gould) in the Iman basin, Far East Russia. Threatened Waterfowl Research Group. B. Hughes and J. Hunter, Ed., p.11-17.  
  40. Zaykin DV and Pudovkin AI 1993. Two programs to estimate significance of Chi-square values using pseudo-probability test. J. of Heredity 84: 152.  
  41. Polyakova NE, Malinina TV, Galeev AV, Zaikin DV, Brykov VA, Altukhov YP. 1992. Variability in the mitochondrial DNA of the pink salmon Oncorhynhus gorbusha (Walbaum). Russian Journal of Genetics 28: 122-129.  
  42. Zaykin DV and Pudovkin AI. 1991. Programme MULTTEST: calculation of indices of statistical significance for multiple tests. Russian Journal of Genetics 27: 2034-2038.  
  43. Balakirev ES and Zaykin DV. 1990. Allozyme polymorphism of glutathione reductase in marine invertebrates. Isozyme Bulletin 23: 90.  
  44. Balakirev ES and  Zaykin DV. 1990. Allozyme variability of formaldehyde dehydrogenase - a new gene marker in marine invertebrates. Isozyme Bulletin 23: 91.  
  45. Balakirev ES and Zaykin DV. 1988. Allozyme variability of formaldehyde dehydrogenase in marine invertebrates. Russian Journal of Genetics 24: 1504-1507

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