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Your Environment. Your Health.

Grace E. Kissling, Ph.D.

Biostatistics & Computational Biology Branch

Grace Kissling, Ph.D.
Grace Kissling, Ph.D.
Staff Scientist
Tel 984-287-3692
123 Carson Road
Chapel Hill, NC 27517

Research Summary

As chief statistician for the National Toxicology Program (NTP), Grace Kissling provides statistical direction and advice, interpretation, and some statistical analyses for the NTP’s rodent bioassays. She also provides support for other testing and evaluation approaches used by the NTP, such as mixtures research, high throughput screening, the Report on Carcinogens, and alternatives to animal testing.

Kissling serves as Contracting Officer’s Representative for the NIEHS/NTP Statistical Support contract, and oversees the day-to-day statistical analysis and mathematical modeling work of the contractor. Her research interest includes applications of biostatistics to toxicology/carcinogenesis and human studies and, as such, collaborates with researchers in the Division of Intramural Research Division, the Division of the NTP, and the extramural community on laboratory experiments and human studies. She is also the statistical consultant and a member of the NIEHS Animal Care and Use Committee.

Selected Publications

  1. Nwosu VC, Kissling GE, Trempus CS, Honeycutt H, French JE.  Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways. Toxicology and Applied Pharmacology 2004; 196(1):37-46. [Abstract]
  2. Salo PM, Xia J, Johnson CA, Li Y, Kissling GE, Avol EL, Liu C, London SJ.  Respiratory symptoms in relation to residential coal burning and environmental tobacco smoke among early adolescents in Wuhan, China: a cross-sectional study. Environmental Health 2004; 3:14. [Abstract]  
  3. Bebenik A, Carver GT, Kadyrov FA, Kissling GE, Drake JW.  Processivity clamp gp45 and ssDNA-binding-protein gp32 modulate the fidelity of bacteriophage RB69 DNA polymerase in a sequence-specific manner, sometimes enhancing and sometimes compromising accuracy.  Genetics 2005; 169:1815-1824. [Abstract]  
  4. Chen Y, Kissling GE, Negishi M, Goldstein J. The nuclear receptors CAR and PXR cross talk with HNF4α to synergistically activate the human CYP2C9 promoter. Journal of Pharmacology and Experimental Therapeutics 2005; 314:1125-1133. [Abstract]  
  5. Drake JW, Bebenek A, Kissling GE, Peddada S.  Clusters of mutations from transient hypermutability. Proceedings of the National Academy of Sciences 2005; 102:12849-12854. [Abstract]  
  6. Emmen JMA, Couse JF, Elmore SA, Yates MM, Kissling GE, Korach KS.  In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER)α and ERβ null mice indicate a role for ERβ in follicular maturation. Endocrinology, 2005; 146(6):2817-2826. [Abstract]  
  7. Gal P, Kissling G, Young W, Dunaway K, Marsh VA, Jones SM, Shockley DH, Weaver NL, Carlos R, Ransom JL. Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity. Annals of Pharmacotherapy 2005; 39:1029-1033. [Abstract]
  8. Ghanayem BI, Witt KL, El-Hadri L, Hoffler U, Kissling GE, Shelby MD, Bishop JB.  Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect. Biology of Reproduction 2005; 72:157-163. [Abstract]  
  9. Ghanayem BI, Witt KL, Kissling GE, Tice RR, Recio L.  Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: Evidence consistent with a glycidamide-mediated effect.  Mutation Research 2005; 578:284-297. [Abstract]  
  10. Marsh VA, Young W, Dunaway K, Kissling G, Carlos RQ, Jones SM, Shockley DH, Weaver NL, Ransom JL, Gal P. Efficacy of topical anesthetics to reduce pain in premature infants during eye examinations for retinopathy of prematurity. Annals of Pharmacotherapy 2005; 39:829-833. [Abstract]
  11. Nyska A, Yoshizawa K, Jokinen MP, Brix AE, Sells DM, Wyde ME, Orzech DP, Kissling GE, Walker NJ. Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls.  Toxicologic Pathology 2005; 33(3):371-377 [Abstract]
  12. Yoshizawa K, Kissling GE, Johnson JA, Clayton NP, Flagler ND, Nyska A. Chemical-induced atrial thrombosis in NTP rodent studies. Toxicologic pathology 2005; 33:517-532. [Abstract]
  13. Clayton NP, Yoshizawa K, Kissling G, Burka LT, Chan P-C, Nyska A. Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. Experimental and Toxicologic Pathology 2006; 58(4):223-236.
  14. Dumsdorf C, Clark AB, Lin Q, Kissling GE, Yuan T, Kunkel TA, McGregor WG, Kucherlapati R.  Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.  Proceedings of the National Academy of Sciences 2006; 103(48):18083-18088. [Abstract]  
  15. Dunnick J, Blackshear P, Kissling G, Cunningham M, Parker J, Nyska A. Critical pathways in heart function:  Bis(2-chloroethoxy)methane-induced heart gene change in F344 rats.  Toxicologic Pathology 2006; 34:348-356. [Abstract]  
  16. Elangbam CS, Wehe JG, Barton JC, Krull DL, Nyska A, Crabbs T, Kissling GE.  Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats? Experimental and Toxicologic pathology 2006; 58: 89-99. [Abstract]  
  17. Elliott L, Longnecker MP, Kissling GE, London SJ.  Volatile organic compounds and pulmonary function in the third national National Health and Nutrition Examination Survey, 1988-1994.  Environmental Health Perspectives 2006; 114:1210-1214. [Abstract]  
  18. Fortune JM, Welch CM, Kissling GE, Burgers PMJ, Kunkel TA. RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta.  Nucleic Acids Research 2006; 34: 4335-4341. [Abstract]  
  19. Kissling GE, Bernheim NJ, Hawkins WE, Wolfe MJ, Jokinen MP, Smith CA, Herbert RA, Boorman GA. The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity. Toxicological Sciences 2006; 92:143-156. [Abstract]  
  20. Peddada SD and Kissling GE. A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies. Environmental Health Perspectives 2006; 114:537-541. [Abstract]  
  21. Tam NNC, Nyska A, Maronpot RR, Kissling G, Lomnitski L, Suttie A, Bakshi S, Bergman M, Grossman S, Ho SM.  Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants.  The Prostate 2006; 66:57-69. [Abstract]  
  22. Zhong X, Garg P, Stith C, Nick-McElhinny S, Kissling G, Burgers P, Kunkel T. The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.  Nucleic Acids Research 2006; 34: 4731-4742. [Abstract]  
  23. Bennett WD , Hazucha MJ, Folinsbee LJ, Bromberg PA, Kissling GE, London SJ. Acute pulmonary function response to ozone(O3) in young adults as a function of body mass index (BMI). Inhalation Toxicology 2007; 19(14):1147-1154. [Abstract]  
  24. Chan SSL, Santos JH, Meyer JN, Mandavilli BS, Cook Jr. DL, McCash CL, Kissling G, van Houten B, Copeland WC, Walker VE, Witt KL, Bishop JB. Mitochondrial toxicity following perinatal exposure of CD-1 mice to AZT, 3TC, or AZT-3TC. Environmental and Molecular Mutagenesis 2007; 48: 190-200.
  25. DeLozier TC, Kissling GE, Coulter SJ, Dai D, Foley JF, Bradbury JA, Murphy E, Steenbergen C, Zeldin DC, Goldstein JA. Detection of human CYP2C8, CYP2C9 and CYP2J2 in cardiovascular tissues. Drug Metabolism and Disposition 2007; 35:682-688. [Abstract]
  26. Doi AM, Hill G, Seely J, Hailey JR, Kissling G, Bucher JR. α2u-globulin nephropathy and renal tumors in National Toxicology Program studies. Toxicologic Pathology 2007; 35:533-540.
  27. Dunnick JK, Kissling G, Gerken DK, Vallant MA, Nyska A. Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system. Toxicologic Pathology 2007; 35:657-664.
  28. Golumb E, Houminer E, Dunnick J, Kissling G, Borman J, Nyska A, Schwalb H. Occult cardiotoxicity: Subtoxic dosage of bis(2-chloroethoxy)methane impairs cardiac response to simulated ischemic injury.  Toxicologic Pathology 2007; 35(3):383-387. [Abstract]  
  29. Jiang C, Foley J, Clayton N, Kissling G, Jokinen M, Herbert R, Diaz M. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr Mice. Journal of Immunology 2007; 178: 7422-7431. [Abstract]  
  30. Kissling GE, Dertinger S, Hayashi M, MacGregor JT. Sensitivity of the Erythrocyte Micronucleus Assay: Dependence on number of cells scored and inter-animal variability. Mutation Research – Genetic Toxicology and Environmental Mutagenesis 2007; 634(1-2):235-40. [Abstract]  
  31. Melnick RL, Nyska A, Foster PM, Roycroft JH, Kissling GE. Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice. Toxicology 2007; 2-3:126-136. [Abstract]  
  32. Moore AB, Castro L, Yu L, Zheng X, Di X, Sifre MI, Kissling GE, Newbold RR, Bortner CD, Dixon D. Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration. Human Reproduction 2007; 22:2623-2631. [Abstract]
  33. Morrison JP, Satoh H, Foley J, Horton JL, Dunnick JK, Kissling GE, Malarkey DE. N-ethyl N-nitrosourea (ENU)-induced meningiomatosis and meningioma in p16INK4a/p19ARF tumor suppressor gene deficient mice. Toxicologic Pathology 2007; 35:838-845.
  34. Peddada SD, Dinse GE, Kissling GE. Incorporating historical control data when comparing tumor incidence rates. Journal of the American Statistical Association 2007; 102(480):1212-1220. [Abstract]  
  35. Rhodes MC, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RC. Carcinogenesis studies of benzophenone in rats and mice. Food and Chemical Toxicology 2007; 45:843-851.
  36. Sakamoto AN, Stone JE, Kissling GE, McCulloch SD, Pavlov YI, Kunkel TA. Mutator alleles of yeast DNA polymerase zeta. DNA Repair 2007; 6:1829-1838.
  37. Thigpen JE, Setchell KD, Padilla-Banks E, Haseman JK, Saunders HE, Caviness GF, Kissling GE, Grant MG, Forsythe DB. Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague Dawley rats. Environmental Health Perspectives 2007; 115:1717-1726. [Abstract]  
  38. Trempus CS, Morris RJ, Ehinger M, Elmore A, Bortner CD,  Ito M, Cotsarelis G, Nijhof JGW, Peckham J, Flagler N, Kissling G, Humble MM, King LC, Adams LD, Desai D, Amin S, Tennant RW. CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Research 2007; 67:4173-4181.
  39. Witt KL, Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB.  Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV.  Environmental and Molecular Mutagenesis  2007; 48(3-4):322-329. [Abstract]  
  40. Chan P-C, Sills RC, Kissling GE, Nyska A, Richter W.  Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344 /N Rats and B6C3F1 Mice. Archives of Toxicology 2008; 82:399-412.
  41. Chan P-C, Hill GD, Kissling GE, Nyska A.  Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice. Archives of Toxicology 2008; 82:45-53.
  42. Dixon D, Herbert R, Kissling G, Brix A, Miller R, Maronpot RR.  Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies. Toxicologic Pathology 2008; 36:428-439.
  43. Hard GC, Seely JC, Kissling GE, Betz LJ. Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the National Toxicology Program (NTP). Toxicologic Pathology 2008; 36(3):388-396. [Abstract]  
  44. Hermon T, Moore A, Yu L, Kissling G, Castora F, Dixon D.  Estrogen receptor alpha (ERα) phospho-Serine-118 is highly expressed in human uterine leiomyoma compared to matched myometrium. Virchows Archiv 2008; 453:557-569. [Abstract]
  45. Jeong Y-C, Walker NJ, Burgin DE, Kissling G, Gupta M, Kupper L, Birnbaum LS, Swenberg JA. Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. Free Radical Biology and Medicine 2008; 45:585-591.
  46. Kissling GE, Portier CJ, Huff J. MtBE and cancer in animals: statistical issues with poly-3 survival adjustments for lifetime studies. Regulatory Toxicology and Pharmacology : RTP 2008; 50(3):428-429. [Abstract]  
  47. Longnecker MP, Smith CS, Kissling GE, Hoppin JA, Butenhoff JL, Decker E, Ehresman DJ, Ellefson ME, Flaherty J, Gardner MS, Langlois E, LeBlanc A, Lindstrom AB, Reagen WK, Strynar MJ, Studabaker WB. An interlaboratory study of perfluorinated alkyl compound levels in human plasma. Environmental Science and Technology 2008; 107(2):152-159. [Abstract]  
  48. Mackwan RR, Carver GC, Kissling GE, Drake JW, Grogan DW. The rate and character of spontaneous mutation in Thermus thermophilus HB27. Genetics 2008; 180:17-25.
  49. Moore AB, Flake GP, Swartz CD, Heartwell G, Cousins D, Haseman JK, Kissling GE, Sidawy MK, Dixon D.  Association of race, age and body mass index with gross pathology of uterine fibroids. Journal of Reproductive Medicine 2008; 53(2):90-96. [Abstract]  
  50. Stout MD, Herbert RA, Kissling GE, Suarez F, Roycroft JH, Chhabra RS, Bucher JR. Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following two year inhalation exposure. Toxicology 2008; 244(2):209-219. [Abstract]  
  51. Stout MD, Kissling GE, Suárez FA, Malarkey DE, Herbert RA, Bucher JR. Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice. Toxicologic Pathology 2008; 36:783-794. [Abstract]  
  52. Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutation research 2008; 649(1-2):101-113. [Abstract]  
  53. Witt KL, Shelby MD, Itchon-Ramos N, Faircloth M, Kissling GE, Chrisman A, Ravi H, Murli H, Mattison D, Kollins SH. Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 2008; 47: 1375-1383. [Abstract]
  54. Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, Dixon D. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Molecular Medicine 2008; 14:264-275. [Abstract]
  55. Yucesoy B, Johnson VJ, Kissling GE, Fluharty K, Kashon ML, Slaven J, Germolec D, Vallyathan V, Luster MI. Genetic susceptibility to progressive massive fibrosis in coal miners. European Respiratory Journal 2008; 31:1177-1182. [Abstract]
  56. Zhang L, Ding H, Yan J, Hui R, Wang W, Kissling GE, Zeldin DC, Wang DW. Genetic variation in cytochrome P450 2J2 and soluble expoxide hydrolase and the risk of ischemic stroke in a Chinese cohort. Pharmacogenetics and Genomics 2008; 18:45-51. [Abstract]
  57. Boyd WA, Smith MV, Kissling GE, Rice JR, Snyder DW, Portier CJ, Freedman JH.  Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development. PLoS ONE 2009; 4(9):e7024.
  58. Cullen JM, Brown DL, Kissling GE, Foley JF, Rizzo J, Marion PL, Parron VI, French JE. Aflatoxin B1 and/or hepatitis B virus induced tumor spectrum in a genetically engineered hepatitis B virus expression and Trp53 haploinsufficient mouse model system for hepatocarcinogenesis. Toxicologic Pathology 2009; 37:1-10. [Abstract]  
  59. Hewitt SC, O'Brien J , Jameson L, Kissling G , Korach KS. Selective disruption of ERα DNA-binding activity alters uterine responsiveness to estradiol. Molecular Endocrinology 2009; 23(12):2111-2116. [Abstract]  
  60. Jefferson W, Doerge D, Padilla-Banks E, Woodling KA, Kissling GE, Newbold R.  Oral exposure to genistein, the glycosylated form of genistein, during neonatal life causes adverse effects on the female reproductive system. Environmental Health Perspectives 2009; 117:1883-1889.
  61. Kissling GE, Malarkey DE, Vallant MK, Johnson JD, Hejtmancik MR, Herbert RA, Boorman GA.  Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC and p53 haploinsufficient mice.  Toxicological Sciences 2009; 107:19-26. [Abstract]
  62. Ramot Y, Nyska A, Lieuallen W, Maly A, Flake G, Kissling G, Brix A, Malarkey D, Hooth M. Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed 2 years to tetrachloroazobenzene (TCAB). Toxicology 2009; 265(1-2):1-9. [Abstract]  
  63. Sanders JM, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RS.  Carcinogenesis studies of cresols in rats and mice.  Toxicology 2009; 257:33-39.
  64. Schindler EM, Hindes A, Gribben EM, Yin Y, Kissling G, Owen RJ, Longmore GD, Arthur JSC, Efimova T. p38δ mitogen-activated protein kinase is essential for skin tumor development in mice.  Cancer Research 2009; 69:4648-4655. [Abstract]  
  65. Smith MV, Boyd W, Kissling GE, Rice JR, Snyder DW, Portier CJ, Freedman JH.  A discrete time model for the analysis of medium-throughput C. elegans growth data.  PLoS ONE 2009; 4(9):e7018. [Abstract]
  66. Stone JE, Kissling GE, Lujan SA, Rogozin IB, Stith CM, Burgers PM, Kunkel TA. Low fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase ζ. Nucleic Acids Research 2009; 37: 3774-3787.
  67. Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Malarkey DE, Hooth MJ.  Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.  Environmental Health Perspectives 2009; 117:716-722.
  68. Stout MD, Nyska A, Collins BJ, Witt KL, Kissling GE, Malarkey DE, Hooth MJ. Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years. Food and chemical toxicology 2009; 47(4):729-733. [Abstract]  
  69. Yoshizawa K, Brix AE, Sells DM, Jokinen MP, Wyde M, Orzech DP, Kissling GE, Walker NJ, Nyska A.  Reproductive lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin and dioxin-like compounds. Toxicologic Pathology 2009; 37:921-937.
  70. Blystone CR, Kissling GE, Bishop JB, Chapin RE, Wolfe GW, Foster PMD. Determination of the di-(2-ethylhexyl) phthalate (DEHP) NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood. Toxicological Sciences 2010; 116(2):640-646. [Abstract]  
  71. Boyd WA, Smith MV, Kissling GE, Freedman JH. Medium and high throughput screening of neurotoxicants using C. elegans. Neurotoxicology and Teratology 2010; 32:68-73. [Abstract]  
  72. Chan P-C, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. Fourteen-week toxicity study of green tea extract in rats and mice. Toxicologic pathology 2010; 38(7):1070-1084. [Abstract]  
  73. Collins BJ, Stout MD, Levine KE, Kissling GE, Fennell T, Pritchard J, Fernando R, Burka LT, Hooth MJ. Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared to trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice. Toxicological Sciences 2010; 118:368-379. [Abstract]  
  74. Ding H, Zhang L, Wu B, Wang Q, Hui R, Wang W, Dackor RT, Kissling GE, Zeldin DC, Wang DW. Association of common variants of CYP4A11 and CYP4F2 with stroke in the Chinese Han population. Pharmacogenetics and Genomics 2010; 20:187-194. [Abstract]  
  75. Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biology of Reproduction 2010; 82:96-104. [Abstract]  
  76. Hewitt SC, Kissling GE, Fieselman KE, Jayes FL, Gerrish KE, Korach KS. Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. The FASEB Journal 2010; 24(12):4660-4667 [Abstract]  
  77. Kim YS, Harry GJ, Kang HS, Goulding D, Wine R, Kissling GE, Liao G, Jetten AM. Altered Cerebellar Development in Nuclear Receptor TAK1/TR4 Null Mice is Associated with Deficits in GLAST(+) Glia, Alterations in Social Behavior, Motor Learning, Startle Reactivity, and Microglia. Cerebellum 2010; 9(3):310-323. [Abstract]  
  78. Moore AB, Yu L, Swartz CD, Zheng X, Wang L, Castro L, Kissling GE, Walmer DK, Robboy SJ, Dixon D. Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production with activation of RTKs and TGF beta receptor signaling in coculture. Cell Communication and Signaling 2010, 8:10. [Abstract]  
  79. Nick McElhinney SA, Kissling GE, Kunkel TA. Differential correction of lagging strand replication errors made by DNA polymerases α and δ. Proceedings of the National Academy of Sciences 2010; 107(49):21070-21075. [Abstract]  
  80. Poltoratsky V, Heacock M, Kissling GE, Prasad R, Wilson SH. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular Immunology 2010; 48:164-170. [Abstract]  
  81. Rana R, Chen Y, Ferguson S, Kissling GE, Surapureddi S, Goldstein JA. Hepatocyte nuclear factor 4α regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes. Drug Metabolism and Disposition 2010; 38:591-599. [Abstract]  
  82. Singh BP, Nyska A, Kissling GE, Lieuallen W, Johansson SL, Malarkey DE, Hooth MJ. Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB). Toxicologic pathology 2010; 38(3):372-381. [Abstract]  
  83. Whiteside TE, Thigpen JE, Kissling GE, Grant MG, Forsythe DB. Endotoxin, coliforms and dust levels in various types of rodent bedding. Journal of the American Association for Animal Laboratory Science 2010; 49:184-189. [Abstract]  
  84. Witt KL, Malarkey DE, Hobb CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environmental and molecular mutagenesis 2010; 51(1):80-88. [Abstract]  
  85. Yoshizawa K, Walker NJ, Kissling GE, Jokinen MP, Brix AE, Sells DM, Nyska A., Wyde ME. Thyroid follicular lesions induced by oral treatment for two years with 2,3,7,8-tetrachlorodi-benzo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats. Toxicologic pathology 2010; 38(7):1037-1050. [Abstract]  
  86. Zegre-Cannon C, Kissling GE, Hoenerhoff MJ, King-Herbert AP, Blankenship-Paris T.  Evaluation of dosages and routes of administration of tramadol analgesia in rats using hot plate and tail-flick tests. Laboratory Animal 2010; 39:342-351. [Abstract]  
  87. Bernstein DI, Kissling GE, Cartier A, Yucesoy B, Gautrin D, Sastre J, Boulet LP, Malo JL, Quirce S, Tarlo S, Hershey GK, Johnson V, Langmeyer S, Lummus ZL.  Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL4Rα. [Letter to the editor]. Journal of Allergy and Clinical Immunology 2011; 128:418-420. [Abstract]
  88. Brodie B, Pokharel Y, Fleishman N, Bensimhon A, Kissling G, Hansen C, Milks S, Cooper M, McAlhany C, Stuckey T. Very late stent thrombosis after primary percutaneous coronary intervention with bare metal stents and drug-eluting stents for ST-elevation myocardial infarction: A 15 year single-center experience. Journal of the American College of Cardiology: Cardiovascular Interventions 2011; 4(1):30-38. [Abstract]  
  89. Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP. Two-Year Toxicity and Carcinogenicity Studies of Panax Ginseng in Fisher 344 Rats and B6C3F1 Mice. The American journal of Chinese medicine 2011; 39(4):779-788. [Abstract]  
  90. Clark AB, Lujan SA, Kissling GE, Kunkel TA. Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase epsilon. DNA Repair 2011; 10(5):476-482. [Abstract]  
  91. Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Abdo K, Pritchard JB, Walden R, Fernando RA, Burka LT, Hooth MJ. Hexavalent chromium in drinking water, Reply [Reply to Letter to the Editor]. Toxicological Sciences 2011; 119(2):425. [Abstract]  
  92. Dunnick JK, Singh B, Nyska A, Peckham J, Kissling GE, Sanders JM. Investigating the potential for toxicity from long-term use of the herbal products, Goldenseal and Milk thistle. Toxicologic pathology 2011; 39(2):398-409. [Abstract]  
  93. Hill GD, Moore AB , Kissling GE , Flagler ND , Ney E, Cline JM , Dixon D. Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation in the Myometrium of Ovariectomized Macaques. Toxicologic pathology 2011; 39(3):508-515. [Abstract]  
  94. Morgan DL, Nyska A, Harbo SJ, Grumbein SL, Dill JA, Roycroft JH, Kissling GE, Cesta MF. Multisite carcinogenicity and respiratory toxicity of inhaled 1-bromopropane in rats and mice. Toxicologic Pathology 2011 39(6):938-948. [Abstract]
  95. Travlos GS, Hard GC, Betz L, Kissling GE. Chronic progressive nephropathy in male F344 rats in 90-day toxicity studies: its occurrence, and association with renal tubule tumors in subsequent 2-year bioassays. Toxicologic pathology 2011; 39:381-389.  
  96. Trempus CS, Wei S-J, Humble MM, Dang H, Bortner CD, Sifre M, Kissling GE, Sunman JA, Akiyama SK, Roberts JD, Tucker CJ, Chun K-S, Tennant RW, Langenbach R.  A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice.  Molecular Carcinogenesis 2011; 50:981-991.
  97. Tubbs JT, Kissling GE, Travlos GS, Goulding DR, Clark JA, King-Herbert AP, Blankenship-Paris TL. Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice. Journal of the American association for laboratory animal science 2011; 50(2):185-191. [Abstract]  
  98. Zegre-Cannon C, Kissling GE, Goulding DR, King-Herbert AP, Blankenship-Paris T.  Analgesic effects of tramadol, carprofen, or multimodal analgesia in rats undergoing ventral laparotomy.  Laboratory Animal 2011; 40:85-93. [Abstract]
  99. Brodie B, Pokharel Y, Garg A, Kissling G, Hansen C, Milks S, Cooper M, McAlhany C, Stuckey T. Predictors of early, late, and very late stent thrombosis after primary PCI with bare metal and drug-eluting stents for STEMI. Journal of the American College of Cardiology: Cardiovascular Interventions 2012; in press.
  100. Burd CJ, Ward JM, Davis VJ, Kissling GE, Phadke D, Shah RR, Archer TK. Analysis of chromatin dynamics during glucocorticoid receptor activation. Molecular and Cellular Biology 2012; 32:1805-1817. [Abstract]
  101. Cora MC, Neel JA, Grindem CB, Kissling GE, Hess PR.  Comparison of automated neutrophil count to manual neutrophil count including blood smear evaluation for the detection of cellular abnormalities and monitoring of neutrophil counts in dogs receiving chemotherapy. Journal of the American Veterinary Medical Association 2012; in press.
  102. Koivisto C, Flake GP, Kolenda-Roberts H, Masinde T, Kissling GE, Sills RC, Hoenerhoff MJ. Immunohistochemical investigation of F344/N rat islet cell tumors from National Toxicology Program Studies.  Toxicologic Pathology 2012; 40:751-763. [Abstract]
  103. Recio L, Kissling GE, Hobbs C, Witt K.  Comparison of comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues.  Environmental and Molecular Mutagenesis 2012; 53:101-113. [Abstract]
  104. Richter K, Burch L, Chao F, Jiang C, Daly J, Ray M, Kissling G, Diaz M. Altered Pattern of Immunoglobulin Hypermutation in MiceDeficient in Slip-GC Gene. The Journal of biological chemistry 2012 287(38):31856-65. [Abstract]
  105. Thigpen JE, Setchell KDR, Kissling GE, Locklear J, Caviness GF, Whiteside T, Belcher SM, Brown NM, Collins BJ, Lih FB, Tomer KB, Padilla-Banks E, Camacho L, Adsit F, Grant M.  The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol a studies.  Journal of the American Association for Laboratory Animal Science: JAALAS; 2013 52(2):130-141. [Abstract]
  106. Yu L, Moore A, Castro L, Gao X, Huynh H-L, Klippel M, Flagler N, Lu Y, Kissling GE, Dixon D.  Estrogen regulates MAPK-related genes through genomic and nongenomic interactions between IGF-I receptor tyrosine kinase and estrogen receptor-alpha signaling pathways in human uterine leiomyoma cells. Journal of Signal Transduction; doi:10.1155/2012/204236 [Online 9 October 2012].
  107. Yucesoy B, Johnson VJ, Lummus ZL, Kissling GE, Fluharty K, Gautrin D, Malo JL, Cartier A, Boulet LP, Sastre J, Quirce S, Germolec DR, Tarlo SM, Cruz MJ, Munoz X, Luster MI, Bernstein DI. Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma. Toxicological Sciences 2012 129(1):166-73. [Abstract]
  108. Witt KL, Stout MD, Herbert RA, Travlos GS, Kissling GE, Collins BJ, Hooth MJ. (2013) Mechanistic Insights from the NTP Studies of Chromium. Toxicologic pathology 41(2):326-342. [Abstract]
  109. Longnecker MP, Harbak K, Kissling GE, Hoppin JA, Eggesbo M, Jusko TA, Eide J, Koch HM. The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling. Environmental research 126:211-214, 2013. [Abstract]
  110. Kissling GE, Grogan DW, Drake JW. Confounders of mutation-rate estimators: Selection and phenotypic lag in Thermus thermophilus. Mutation Research 2013 749(1-2):16-20. [Abstract]
  111. George MD, Wine RN, Lackford B, Kissling GE, Akiyama SK, Olden K, Roberts JD. p38 mitogen-activated protein kinase interacts with vinculin at focal adhesions during fatty acid-stimulated cell adhesion. Biochemistry and cell biology = Biochimie et biologie cellulaire 2013 91(6):404-418. [Abstract]
  112. Flake GP, Moore AB, Flagler N, Wicker B, Clayton N, Kissling GE, Robboy SJ, Dixon D. The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis. Obstetrics and gynecology international 2013 2013:285103-. [Abstract]
  113. Kim JM, Kosak JP, Kim JK, Kissling G, Germolec DR, Zeldin DC, Bradbury JA, Baek SJ, Eling TE. NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response. Mediators of inflammation 2013 2013():641851-641851. [Abstract]
  114. Nichols HB, Baird DD, DeRoo DD, Kissling GE, Sandler DP. Tubal ligation in relation to menopausal symptoms and breast cancer risk. British journal of cancer 2013 3(109):1291-1295. [Abstract]
  115. Brodie BR, Pokharel Y, Garg A, Kissling G, Hansen C, Milks S, Cooper M, McAlhany C, Stuckey TD. Very Late Hazard with Stenting versus Balloon Angioplasty for ST-Elevation Myocardial Infarction: A 16-Year Single-Center Experience. Journal of interventional cardiology 2014 27(1):21-28. [Abstract]
  116. Resnik DB, Parasidis E, Carroll K, Evans JM, Pike E, Kissling GE. Research-Related Injury Compensation Policies of U.S. Research Institutions. IRB 2014 36(1):12-20. [Abstract]
  117. Surh I , Rao DB, Cesta MF, Hébert CD, Mann JF, Cunny H, Kissling GE, Malarkey D, Chhabra RS. Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. Food and chemical toxicology 2014 66:254-261. [Abstract]
  118. Jayes FL, Burns KA, Rodriguez KF, Kissling GE, Korach KS. The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. Biology of reproduction 2014 90(2):24-. [Abstract]
  119. Ray M, Shockley K, Kissling G. Minimizing Systematic Errors in Quantitative High Throughput Screening Data Using Standardization, Background Subtraction, and Non-Parametric Regression. Journal of Experimental Secondary Science 2014 3(2):-. [Abstract]
  120. Livingston DP 3rd, Tuong TD, Kissling GE, Cullen JM. Visualizing surface area and volume of lumens in three dimensions using images from histological sections. Journal of Microscopy 2014 256(3):190-196. [Abstract]
  121. Ferguson SA, Law CD, Kissling GE. Developmental treatment with ethinyl estradiol, but not bisphenol A, causes alterations in sexually dimorphic behaviors in male and female Sprague Dawley rats. Toxicological sciences: an official journal of the Society of Toxicology 2014 140(2):374-392. [Abstract]
  122. Parks CG, Miller FW, Satoh M, Chan EK, Andruschenko Z, Birnbaum LS, Jusko TA, Kissling GE, Patel MD, Rose KM, Weinberg C, Zeldin DC, Sandler DP. Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 23(11):2492-2502.  [Abstract]
  123. Rider CV, Nyska AN, Cora MC, Kissling GE, Smith C, Travlos GS, Hejtmancik MR, Kooistra L, Morrison JP, Chan PC. Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicologic pathology 2014 42(5):830-843. [Abstract]
  124. Resnik DB, Neal T, Raymond A, Kissling GE. Research misconduct definitions adopted by U.S. research institutions. Accountability in research 2015 22(1):14-21. [Abstract]
  125. Resnik DB , Rasmussen LM, Kissling GE. An international study of research misconduct policies. Accountability in research 2015 22(5):249-266. [Abstract]
  126. Quist EM, Filgo AJ, Cummings CA, Kissling GE, Hoenerhoff MJ, Fenton SE. Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA). Toxicologic pathology 2015 43(4):546-557. [Abstract]
  127. Resnik DB, Wager E, Kissling GE. Retraction policies of top scientific journals ranked by impact factor. Journal of the Medical Library Association: JMLA 2015 103(3):136-139.
  128. Hong HH, Hoenerhoff MJ, Ton TV, Herbert RA, Kissling GE, Hooth MJ, Behl M, Witt KL, Smith-Roe SL, Sills RC, Pandiri AR7. Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Toxicologic pathology 2015 43(6):872-882. [Abstract]
  129. Kissling GE, Haseman JK, Zeiger E. Proper interpretation of chronic toxicity studies and their statistics: A critique of "Which level of evidence does the US National Toxicology Program provide? Statistical considerations using the Technical Report 578 on Ginkgo biloba as an example". Toxicology letters 2015 237(2):161-164. [Abstract]
  130. Gao X, Yu L , Moore AB, Kissling GE, Waalkes MP, Dixon D. Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways. Environmental health perspectives 2015 123(4):331-336. [Abstract]
  131. Yucesoy B, Kissling GE, Johnson VJ, Lummus ZL, Gautrin D, Cartier A, Boulet LP, Sastre J, Quirce S, Tarlo SM, Cruz MJ, Munoz X, Luster MI, Bernstein DI. N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 2015 57(12):1331-1336 [Abstract]
  132. Filgo AJ, Quist EM, Hoenerhoff MJ, Brix AE, Kissling GE, Fenton SE. Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPARα Is Not Required. Toxicologic pathology 2015 43(4):558-568. [Abstract]
  133. Thayer KA, Doerge DR, Hunt D, Schurman S, Twaddle NC, Churchwell MI, Garantziotis S, McCarver G, Kissling GE, Easterling MR, Bucher JR, Divakaran K, Birnbaum LS. Pharmacokinetics of bisphenol A in humans following a single oral administration. Environment international 2015 83():107-15-107-15. [Abstract]
  134. Resnik DB, Tyler AM, Black JR, Kissling G. Authorship policies of scientific journals. Journal of medical ethics 2016 42(3):199-202. [Abstract]
  135. Castro L, Moore AB , Gao X, Yu L, Di X, Kissling GE , Dixon D. A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. Expert Opin Environ Biol, 2016;5(Suppl 1). doi: 10.4172/2325-9655.S1-003. [Abstract]
  136. Resnik DB, Ariansen JL, Jamal J, Kissling GE. Institutional Conflict of Interest Policies at U.S. Academic Research Institutions. Academic medicine: journal of the Association of American Medical Colleges 2016 91(2):242-246.  [Abstract]
  137. Thayer KA, Doerge DR, Taylor KW, Garantziotis S, Schurman S, Kissling GE, Hunt D, Herbert B, Church R, Crozier R, Churchwell MI, Scheri RC, Birnbaum L, Bucher JR. Bisphenol A, Bisphenol S, and 4-Hydro​xyphenyl 4-Isopro​oxyphenyl​sulfone (BPSIP) in Urine and Blood of Cashiers. Environmental health perspectives 2016 124(4):437-444. [Abstract]
  138. Stanko JP, Kissling GE, Chappell VA, Fenton SE. Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure. Toxicologic pathology 2016 44(7):1021-1033. [Abstract]
  139. Wyss AB, Jones AC, Bølling AK, Kissling G, Chartier R, Dahlman HJ, Rhodes C, Archer J, Thornburg J, Schwarze PE, London SJ. Particulate Matter 2.5 Exposure and Self-Reported Use of Wood Stoves and Other Indoor Combustion Sources in Urban Nonsmoking Homes in Norway. PloS one 2016 11(11):-. [Abstract]
  140. Ogburn RN, Randall TA, Xu Y, Roberts JH, Morgan MS, Rider SD, Vyszenski-Hoher DL, Kissling GE, London RE, Pomes A, Arlian L, Fitzgerald MC, Mueller GA. Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins? The Journal of allergy and clinical immunology 2016 ():-. [Abstract]
  141. Resnik DB, Konecny B, Kissling GE. Conflict of Interest and Funding Disclosure Policies of Environmental, Occupational, and Public Health Journals. Journal of occupational and environmental medicine 2017 59(1):28-33. [Abstract]

Book Chapters

  1. Brunssen SH, Moy SS, Kissling GE. Behavioral principles and phenotyping of mice: Developmental and adult life stages. In: Harry and Tilson, eds. Neurotoxicology. 2010: Chapter 12 (p. 283-308), 3rd edition.
  2. Melnick RL and Kissling GE. Evaluation of human cancer risk from animal studies. Book chapter. In: E. Melnick and B. Everitt, eds. Encyclopedia of Quantitative Risk Analysis and Assessment. New York, John Wiley & Sons 2008.
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