The Division of the National Toxicology Program (DNTP) conducts innovative toxicology research that aligns with real-world public health needs and translates scientific evidence into knowledge that can inform individual and public decision making.
The DNTP research portfolio is organized and executed using a strategic framework based on three objectives:
- Accelerate our progress toward becoming a more predictive, precise, and preventive science through the deliberate application of a translational toxicology pipeline of capabilities.
- Provide an evidence-based approach to identifying and understanding potential environmental contributors to contemporary and common diseases.
- Improve our ability to conduct and communicate substance-based hazard evaluations that are more translational, innovative, and responsive.
DNTP scientists aim to achieve those goals through the program areas below. Explore each program and learn how the researchers are tackling issues ranging from cardiovascular health and developmental neurotoxicity to occupational exposures and scientific cyberinfrastructure.

Exposure-based Research Programs
This strategic area of focus aligns with DNTP’s intent to solve contemporary public health problems related to environmental exposures and includes the following program areas:
- Combined Exposures and Mixtures
- Consumer Products and Therapeutics
- Occupational and Inhalation Exposure

Health Effects Innovation Programs
This strategic area of focus aligns with DNTP’s intent to develop disease-focused environmental toxicology and includes the following program areas:
- Carcinogenicity Health Effects Innovation
- Cardiovascular Health Effects Innovation
- Developmental Neurotoxicity Health Effects Innovation

Responsive Research Programs
This strategic area of focus aligns with DNTP’s intent to respond proactively to public health concerns related to novel environmental exposures and includes the following program areas:
- Emerging Contaminants and Issues of Concern
- Safe and Sustainable Alternatives

Strengthening Capabilities Programs
This strategic area of focus aligns with DNTP’s intent to enhance toxicology toward becoming a more predictive science through the development and application of new technologies and includes the following program areas:
- Novel Tools and Approaches
- Scientific Cyberinfrastructure
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