Metastasis in Motion
Laboratory of Molecular Carcinogenesis
Figure 1. This movie clip is an animation of the early steps in the metastatic cascade. It depicts a normal cell changing to a tumor cell, invading through the basement membrane, migrating away from the original tumor toward a blood vessel, and intravasating into the blood vessel where it is carried away by normal blood flow.
Figure 2. This movie clip is an animation of the later steps in the metastatic cascade. It depicts a tumor cell floating through a blood vessel with other normal cells and attaching through specific receptors to the endothelial cells lining the blood vessel. The tumor cell then extravasates from the blood vessel, migrates to a nearby site and attaches to the extracellular matrix, where it begins to divide and form the basis of a metastatic colony of cells.