News Release
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Thursday, March 20, 2003, 12:00 p.m. EDT
In April, as the world marks the 50th anniversary of Watson and Crick's Nobel Prize-winning description of the DNA double helix, the National Institute of Environmental Health Sciences will look beyond the historic sequencing of the human genome to new and future studies of how variations in our genes can interact with the environment to cause disease.
In cooperation with the National Human Genome Research Institute and the National Institute on Alcohol Abuse and Alcoholism , the National Institute of Environmental Health Sciences will host a half-day public symposium beginning at 8:30 a.m. April 16 in the Masur Auditorium of the Clinical Center (Building 10) NIH, Bethesda, Md., on Genetic Variation and Gene-Environment Interaction in Human Health and Disease. The meeting will provide opportunities for an in-depth consideration of DNA variations that can interact with environmental triggers to cause disease.
Although we all have the same genes, individual genes vary slightly in each of us, making some of us far more susceptible to environmental insults and chemicals than others are. Some smokers get lung cancer, for example, while others do not.
Talks on DNA variation in gene-environment interaction research and its implications to human disease will be presented. NIEHS Deputy Director Samuel Wilson, M.D., Ph.D., and Lisa Brooks, Ph.D., Program Director, Genetic Variation and Genome Information for NHGRI, will chair the symposium.
For more information contact David Brown, NIEHS, (919) 541-5111.
| 8:30-8:40 | Welcome and Introduction |
| Session I | CHAIR: Lisa Brooks, NHGRI, NIH |
| 8:40-9:10 | Patterns of Human Genetic Variation |
| 9:10-9:40 | SNPing in the Human Genome |
| 9:40-10:10 | Influence of DNA Variation on Gene Expression |
| 10:10-10:40 | Relating Variation to Phenotype |
| 10:40-10:50 | BREAK |
| Session II | CHAIR: Samuel Wilson, NIEHS, NIH |
| 10:50-11:20 | Functional Genomics of Paraoxonase (PON1) Polymorphisms |
| 11:20-11:50 | Gene-Environment Interaction Related to Alcohol Use and Its Consequences |
| 11:50-12:20 | Gene-Environment Interactions in BRCA Related Breast Cancer |
| 12:20- 12:50 | Gene-Environment Interactions in Human Leukemia |
| 12:50-1:30 | Audience Participation and Discussion |
NIEHS supports research to understand the effects of the environment on human health and is part of NIH. For more information on environmental health topics, visit http://www.niehs.nih.gov (http://www.niehs.nih.gov/index.cfm) . Subscribe to one or more of the NIEHS news lists ( http://www.niehs.nih.gov/news/newslist/index.cfm (http://www.niehs.nih.gov/news/newsroom/newslist/index.cfm) ) to stay current on NIEHS news, press releases, grant opportunities, training, events, and publications.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov (http://www.nih.gov/) .
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