Archive - New Contact Information
Thursday, September 3, 1998, 12:00 p.m. EDT
Results from a study conducted jointly by Australian and American scientists indicate that lead which has accumulated in a woman's bones from earlier exposures can be released during pregnancy and transferred to breast milk during lactation. This can translate into increased exposures for breast-fed infants whose mothers have a long-term history of lead exposure themselves.
The report appears today in the online version of the October issue of Environmental Health Perspectives, the monthly journal of the National Institute of Environmental Health Sciences. The study was co-funded by NIEHS and the National Institutes of Health's Office of Research on Minority Health.
"We should point out that breast feeding is still an important option for healthy mothers," said Brian Gulson, Ph.D., a toxicologist with Macquarie University in Sydney, Australia, and chief investigator for the project. "What we are saying is that breast-fed infants are only at risk if the mother has been previously exposed to high concentrations of lead from external sources such as leaded paint, pottery, or, in many other countries, industrial sources and leaded gasoline."
While previous research had demonstrated that lead is stored in bones, scientists could not quantify its release into the blood and other bodily fluids. To answer that question, the researchers compared second-generation Australian women with women who had migrated to Australia from Eastern Europe.
Since lead found in Eastern Europe has a slightly different atomic weight than lead found in Australia, the scientists were able to differentiate between skeletal lead deposits that had accumulated from the immigrants' earlier exposures while in their native country, and the lead burden received from more recent exposures. Hence, any circulating blood lead that matched the "Eastern European" profile could only be derived from skeletal stores.
Earlier data from the same study had shown that as much as 40 to 70 percent of the blood lead in pregnant women can come from lead that has accumulated in the bones. Additional analyses had revealed a significant increase in the mobilization of maternal skeletal lead during lactation. "Based on these observations, we wondered whether the infants born to these mothers might be at greater risk from breast feeding than from formula," said Gulson.
Because the study participants' blood lead concentrations were relatively low-most had values less than 5 micrograms lead per deciliter (100 milliliters) of blood-the lead concentrations in their breast milk were also low - 0.7 parts per billion on average. These concentrations were not significantly different from those found in various kinds of infant formulae.
In spite of these low concentrations, the researchers found a strong correlation between the amount of lead in the mothers' milk samples and the corresponding blood lead levels of the infants. In fact, calculations based on the first 60 to 90 days postpartum indicated that 36 to 80 percent of the infants' total blood lead was coming from breast milk or formula.
"Our data indicate that lead from urban air and water where these infants reside contributed negligibly to blood lead, while soil and dust were not considered to be relevant sources because these infants had not reached the stage of crawling and ubiquitous hand-to-mouth activity," said Gulson. "Therefore, we concluded that dietary lead was the primary source contributing to the body burden observed in these subjects, with a major part of the dietary lead ultimately derived from the mothers' bones."
The researchers also found a statistical link between the lead concentration in the maternal cord blood and lead levels in the first breast milk samples, a finding that could have clinical significance. Bill Jameson, Ph.D., the Institute toxicologist who serves as NIEHS project officer for the study, said "If this relationship can be verified through further investigations, then one could obtain an accurate estimate of an infant's lead exposure by simply testing the mother's blood lead."
The study also produced preliminary evidence suggesting that calcium supplementation can have a protective effect by slowing the release of lead from skeletal stores. The Australian researchers are planning additional NIEHS-funded studies to determine calcium's effectiveness in pregnant and nursing mothers.
NIEHS supports research to understand the effects of the environment on human health and is part of NIH. For more information on environmental health topics, visit http://www.niehs.nih.gov (http://www.niehs.nih.gov/index.cfm) . Subscribe to one or more of the NIEHS news lists ( http://www.niehs.nih.gov/news/newslist/index.cfm (http://www.niehs.nih.gov/news/newsroom/newslist/index.cfm) ) to stay current on NIEHS news, press releases, grant opportunities, training, events, and publications.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov (http://www.nih.gov/) .
NIH...Turning Discovery Into Health®