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Environmental Factor, September 2012

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Upcoming international workshop on endocrine active chemicals

By Eddy Ball

Jerry Heindel, Ph.D.

Heindel administers a grants portfolio that supports research on the health effects from exposure to endocrine active chemicals. (Photo courtesy of Steve McCaw)

NIEHS is one of several sponsors of a workshop Sept. 11-13 in Berlin on “Low Dose Effects and Non-monotonic Dose Responses for Endocrine Active Chemicals: Science to Practice.” The workshop will be hosted by Charite Medical University Berlin and is offered at no charge to attendees. Registration is required and limited to 250 attendees.

Organized by NIEHS Health Scientist Administrator Jerry Heindel and a committee of scientists from U.S. and European governmental agencies concerned about endocrine disrupting chemicals in the environment, the goals of this workshop, which were inspired by recent research on the dose response curves of endocrine active chemicals, are the following:

  • To present and discuss the state of the science for low dose effects and non-monotonic dose response curves for chemicals with endocrine activity.
  • To define research needs required to move closer to scientific agreement on the prevalence and importance of low dose effects and non-monotonic dose responses for endocrine active substances.
  • To define how research programs, especially those funded by public agencies, could support studies that would produce data most useful for a science-based risk assessment.
  • To initiate a discussion on the implications of low dose effects and non-monotonic dose response curves to risk assessment.
  • To develop a plan to continue discussions among basic researchers and risk assessment scientists beyond the current workshop.

Other sponsors are the European Commission; French Agency for Food, Environmental and Occupational Health and Safety; the German Federal Environment Agency; and the Danish Ministry of the Environment and National Food Institute. The Pew Charitable Trusts are providing meeting facilitators.

Citation: Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. 2012. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 33(3):378-455.

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