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Environmental Factor, April 2012

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Rodbell lecture to feature Keith Yamamoto

By Eddy Ball

Keith Yamamoto, Ph.D.

As part of his commitment to the future of science, Yamamoto served on the Board on Life Sciences Committee on A New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution, which presented its report to Congress in 2010. (Photo courtesy of UCSF)

Biochemist Keith Yamamoto, Ph.D., will present the 2012 Rodbell Lecture, “Cell-, Gene-, and Physiology-Specific Regulation by the Glucocorticoid Receptor,” April 10 at NIEHS. The presentation, which begins at 11:00 a.m. in Rodbell Auditorium, will be hosted by NIEHS Laboratory of Molecular Carcinogenesis chief Trevor Archer, Ph.D., and NIEHS Laboratory of Signal Transduction chief John Cidlowski, Ph.D.

Yamamoto is a professor of cellular and molecular pharmacology at the University of California, San Francisco (UCSF), where he also serves as vice chancellor for research and executive vice dean of the School of Medicine. His research is focused on signaling and transcriptional regulation by intracellular receptors (IR), which mediate the actions of several classes of essential hormones and cellular signals. The Yamamoto lab employs biochemical, cellular, molecular, genetic, and structural approaches in mammals, C. elegans, and yeast to investigate IR functions and mechanisms.

In the course of his 39-year career at UCSF, Yamamoto has published more than 170 peer-reviewed studies in high-impact journals, edited three books, written some 20 science and public policy articles, and given many distinguished, honorary, and keynote lectures. He has been active in service at UCSF and nationally, and he has served on the editorial boards of 18 major journals. His long list of honors includes an NIH MERIT Award, major fellowships, and this year’s Endocrine Society Edwin B. Astwood Award. 

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Now in its 13th year, the Rodbell Lecture is one of two named talks in the annual NIEHS Distinguished Lecture Series. It honors former NIEHS Scientific Director and Nobel Laureate Martin Rodbell, Ph.D., who presented the first talk in the series shortly before his death in 1998. Rodbell shared the 1994 Nobel Prize in Physiology or Medicine with Alfred Gilman, Ph.D. , for the discovery of G-proteins, signal transducers that transmit and modulate signals in cells to control fundamental life processes.

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