March 20 – 22, 2019
San José, Costa Rica
Workshop Purpose
Chronic Kidney Diseases that cannot be explained by traditional risk factors or of known causes continues to be increasingly recognized in specific geographic regions. The disease, referred to here as Chronic Kidney Disease of uncertain/nontraditional etiology (CKDu), has also been referred to as Mesoamerican Nephropathy (MeN), Chronic Interstitial Nephritis of Agricultural Communities (CINAC), or Kidney Disease of Unknown Cause in Agricultural Laborers (KDUCAL).
A notable burden falls on individuals living in poverty, including agricultural workers and other manual laborers. Despite some advances in research, the etiology of this disease remains unclear. An international workshop is planned through collaboration across the National Institutes of Health (National Institute of Environmental Health Sciences (NIEHS) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)), World Health Organization Regional Offices (Pan American Health Organization (PAHO) and South-East Asia Regional Office (SEARO), and the Consortium for the Epidemic of Nephropathy in Central America and Mexico (CENCAM). This workshop built on the efforts of previous international workshops on Mesoamerican Nephropathy organized by CENCAM, a 2016 workshop on chronic kidney disease in Sri Lanka, and a 2018 workshop on Chronic Kidney Diseases in Agricultural Communities organized by the NIH, expanding the reach to international experts working in known and potentially emerging regions affected by CKDu.
The workshop brought together experts from a range of disciplines and geographic areas. Retaining the spirit of the previous international workshops, all attendees participated in roundtable discussions (meet others/share experiences/exchange ideas) as well as focused working groups with scientific experts. Topics covered four broad themes: Clinical aspects, burden of disease, mechanisms/etiology, and societal response. The content of the working groups and talks included updates on the state of the science, expanded collaboration, standardization of global research protocols, recommendations for intervention and prevention strategies, cross-disciplinary education, and dissemination of workshop results.
Reports from Previous International Workshops
- Report from the First International Research Workshop on MeN
- Report from the Second International Research Workshop on MeN
- Report from the Third International Workshop on Chronic Kidney Diseases of Uncertain/Non-traditional Etiology in Mesoamerica and Other Regions (1MB)
Workshop Agenda and Meeting Materials
- Workshop Agenda (1MB)
- Meeting Book (7MB)
- Published Reports (1MB)
- Additional Articles
- Ethics Research Session Details - English (99KB)
- Policy Session Information
Pre-Workshop Reading
- CKDu_SL Pesticides, Metals and Others Review (577KB)
- Glyphosate and CKDu (37KB)
- Heavy Metal Exposure and CKDu Sri Lanka (462KB)
- Measurement Strategies to Evaluate Occupational Exposure to Pesticides (239KB)
- Metal Exposure and Decreased Renal Function (258KB)
- Metals and CKDu (215KB)
- Most Used Pesticides in Central America (99KB)
- Occupational Pesticide Exposure Assessment (326KB)
- Pesticides and CKDu Mesoamerica (295KB)
Questions?
For questions that can't be answered by the content of this website, please contact:
- Bonnie R. Joubert, Health Scientist Administrator
- Tel 984-287-3276
- bonnie.joubert@nih.gov
Organizing Committee
(members listed below in alphabetical order)- Kevin Abbott, NIDDK
- Daniel Brooks, CENCAM
- Ricardo Correa-Rotter, CENCAM
- Jennifer Crowe, CENCAM
- Marvin González, CENCAM
- Kristina Jakobsson, CENCAM
- Bonnie Joubert, NIEHS
- Paul Kimmel, NIDDK
- Ty Lawson, NIEHS
- Susan Mendley, NIDDK
- Brittany Trottier, NIEHS
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