Atherosclerosis as a Model Workshop
April 3 – 4, 2018
This meeting was co-sponsored by the National Institute of Environmental Health Sciences (NIEHS) and the National Heart, Lung, and Blood Institute (NHLBI).
A critical research area that requires further exploration is the biological mechanisms and effects of exposure to both environmental chemicals (e.g., air pollution, polycyclic aromatic hydrocarbons, metals, pesticides) and non-chemical stressors (e.g., psychosocial, lifestyle, quality of life, poor nutrition, infectious agents, physical stressors) over time and the roles they may play in the development of disease (e.g., cancer, cardiac, metabolic, neurological). The goal of this workshop was to identify key biological mechanisms/pathways of the combined effects of chemical and non-chemical stressors associated with atherosclerosis, a disease known to be initiated by both types of stressors. This workshop brought together experts to discuss the state of the science pertaining to underlying biological pathways associated with, when combined, chemical and non-chemical stressors in relation to this disease.
The workshop utilized the Adverse Outcome Pathway (AOP) framework to assist in the discussion of key biological mechanisms/pathways associated with this disease.
The NIEHS Division of Extramural Research and Training (DERT) and the NHLBI Division of Cardiovascular Sciences (DCVS) released a Request for Information(RFI) on December 5, 2016 to identify key biological mechanisms/pathways of the combined effects of chemical and non-chemical stressors associated with atherosclerosis. Information provided was used in planning of this workshop and to help inform the development of intramural and extramural research efforts that address the combined health effects of environmental chemical and non-chemical stressors associated with atherosclerosis, a known multi-factorial disease. Input from all interested parties was welcome including the lay public, environmental health researchers, health professionals, educators, policy makers, industry, and others. The RFI closed January 31, 2017.