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Your Environment. Your Health.

Agenda

Inflammation and the Environment: The Role of the Mitochondrion and Energy Metabolism

June 20, 2016
Building 101, Rodbell Auditorium
Research Triangle Park, NC

Time Title Name
7:45 a.m. NIEHS Shuttle departs DoubleTree hotel for NIEHS
8:00 a.m. Registration
8:30 a.m. Welcome Richard Woychik, Ph.D.
8:40 a.m. Opening Remarks Frederick Miller, M.D., Ph.D.
Morning Session: The Mitochondrion in Inflammation
Moderator: Jean Harry, Ph.D.
8:50 a.m. Keynote Lecture: Roles for Mitochondria in Activation of the Inflammasome Augustine Choi, M.D. – Weill Cornell Medicine
9:30 a.m. Metabolic Effects of Air Pollution Exposure Sanjay Rajagopalan, M.B.B.S. – University of Maryland School of Medicine
9:55 a.m. Metformin Prevents Particulate Matter Air Pollution Induced Thrombosis Scott Budinger, M.D. – Northwestern University
10:20 a.m. Break
10:35 a.m. Known Unknowns of Mitochondrial Cardiolipin Signaling Valerian Kagan, Ph.D., D.Sc. – University of Pittsburgh
11:00 a.m. Neutrophils and Mitochondrial DNA in Inflammation and Autoimmunity Keith Elkon, M.D. – University of Washington
11:25 a.m. Panel Discussion
  • Question 1: What are the key mechanisms by which mitochondria regulate inflammation and in what diseases are these pathways enacted?
  • Question 2: Which environmental factors impinge on mitochondria to induce or modify inflammation?
  • Question 3: What knowledge gaps in this field are most critical, and how might they be leveraged to advance insight into environment-induced human disease?
Jean Harry, Ph.D.
12:25 p.m. Lunch - NIEHS Cafeteria
Afternoon Session: Metabolic Programming of Inflammation
Moderator: Michael Fessler, M.D.
1:30 p.m. Keynote Lecture: Nuclear Receptors and Lipid Homeostasis in Programming of Inflammation Peter Tontonoz, M.D., Ph.D. – University of California, Los Angeles
2:10 p.m. Metabolism and T Cell Fates Jeff Rathmell, Ph.D. – Vanderbilt University
2:35 p.m. Mitochondrial DNA Stress in Innate Immunity and Type I Interferon Responses A. Philip West, Ph.D. – Southern Methodist University
3:00 p.m. Break
3:15 p.m. Metabolic Calibration of Macrophage Activation Tiffany Horng, Ph.D. – Harvard University
3:40 p.m. Fueling the Fire: Mitochondria and Metabolism in Autoinflammatory Disease Richard Siegel, M.D., Ph.D. – NIAMS
4:05 p.m. Panel Discussion
  • Question 1: What are the key cellular regulators and metabolites that regulate inflammation, and in what diseases do they contribute to pathogenesis?
  • Question 2: Which environmental factors impinge on cellular metabolism to induce or modify inflammation?
  • Question 3: What knowledge gaps in this field are most critical, and how might they be leveraged to advance insight into environment-induced human disease?
Michael Fessler, M.D.
5:00 p.m. Closing Remarks and Charge for Next Day Michael Humble, Ph.D.
5:10 p.m. NIEHS Shuttle to Doubletree Hotel
2515 Meridian Pkwy, Durham, NC 27713
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