June 20, 2016
Building 101, Rodbell Auditorium
Research Triangle Park, NC
7:45 a.m. — NIEHS Shuttle departs DoubleTree hotel for NIEHS
8:00 – 8:30 a.m. — Registration
8:30 – 8:40 a.m. — Welcome
Richard Woychik, Ph.D.
8:40 – 8:50 a.m. — Opening Remarks
Frederick Miller, M.D., Ph.D.
Morning Session: The Mitochondrion in Inflammation
Moderator: Jean Harry, Ph.D.
8:50 – 9:30 a.m. — Keynote Lecture: “Roles for Mitochondria in Activation of the Inflammasome” Augustine Choi, M.D. – Weill Cornell Medicine
9:30 – 9:55 a.m. — “Metabolic Effects of Air Pollution Exposure” Sanjay Rajagopalan, M.B.B.S. – University of Maryland School of Medicine
9:55 – 10:20 a.m. — “Metformin Prevents Particulate Matter Air Pollution Induced Thrombosis" Scott Budinger, M.D. – Northwestern University
10:20 – 10:35 a.m. — Break
10:35 – 11:00 a.m. — “Known Unknowns of Mitochondrial Cardiolipin Signaling” Valerian Kagan, Ph.D., D.Sc. – University of Pittsburgh
11:00 – 11:25 a.m. — “Neutrophils and Mitochondrial DNA in Inflammation and Autoimmunity” Keith Elkon, M.D. – University of Washington
11:25 – 12:25 p.m. — Panel Discussion
Moderator: Jean Harry, Ph.D
Question 1: What are the key mechanisms by which mitochondria regulate inflammation and in what diseases are these pathways enacted?
Question 2: Which environmental factors impinge on mitochondria to induce or modify inflammation?
Question 3: What knowledge gaps in this field are most critical, and how might they be leveraged to advance insight into environment-induced human disease?
12:25 – 1:30 p.m. — Lunch – NIEHS Cafeteria
Afternoon Session: Metabolic Programming of Inflammation
Michael Fessler, M.D.
1:30 – 2:10 p.m. — Keynote Lecture “Nuclear Receptors and Lipid Homeostasis in Programming of Inflammation”
Peter Tontonoz, M.D., Ph.D. – University of California, Los Angeles
2:10 – 2:35p.m. — “Metabolism and T Cell Fates”
Jeff Rathmell, Ph.D. – Vanderbilt University
2:35 – 3:00 p.m. — “Mitochondrial DNA Stress in Innate Immunity and Type I Interferon Responses”
A. Philip West, Ph.D. – Southern Methodist University
3:00 – 3:15 p.m. — Break
3:15 – 3:40 p.m. — “Metabolic Calibration of Macrophage Activation”
Tiffany Horng, Ph.D. – Harvard University
3:40 – 4:05 p.m. — “Fueling the Fire: Mitochondria and Metabolism in Autoinflammatory Disease”
Richard Siegel, M.D., Ph.D. – NIAMS
4:05 – 5:00 p.m. — Panel Discussion
Moderator: Michael Fessler, M.D.
5:00 – 5:05 p.m. — Closing Remarks and Charge for Next Day
Michael Humble Ph.D.
5:10 p.m. — NIEHS Shuttle to Doubletree Hotel (2515 Meridian Pkwy, Durham, NC 27713)
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