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Suggested Publications

Amelie Baud, European Bioinformatics Institute- Cambridge

Elissa Chesler, The Jackson Laboratory

Weihsueh Chiu, Texas A&M University

Martin Ferris, University of North Carolina– Chapel Hill

Samir Kelada, University of North Carolina– Chapel Hill

Brian Parks, University of California, Los Angeles

Richard Paules, National Institute of Environmental Health Sciences (NIEHS)

Daniel Pomp, University of North Carolina– Chapel Hill

Ivan Rusyn, Texas A&M University

Boris Tabakoff, University of Colorado– Denver

David Threadgill, Texas A&M University

Nigel Walker, National Institute of Environmental Health Sciences (NIEHS)

Tim Wiltshire, University of North Carolina– Chapel Hill

Wiltshire’s lab research focuses mainly on pharmacogenetics and broad aspects of drug toxicity. They have used the mouse as an extremely useful model for this work. One of the confounding factors in the response of an organism to a drug or compound is the genetic variance on which the drug is tested. Standard models of drug testing have routinely used only one strain of mouse or rat, but this approach does not take into account the complexity of response that is apparent because of genetic variation. They have used a wide selection of inbred mouse strains, and more recently the Collaborative Cross mice, to screen for variable phenotypic responses to drug. They have focused largely on toxicity responses in in vivo mouse models, but also have championed the use of in vitro “cellular genetics” approaches to identify variable drug response. The key to understanding the variable drug response is to be able to provide associated genetic analysis and identify the genetic variation responsible. Using these mouse models they have been able to identify genes that impact specific drug response pathways.

Additional Background Information

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