March 18 – 19, 2015
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
The unique resources of the Collaborative Cross, Diversity Outbred, Hybrid Diversity panel, and other rodent population-based resources have proven to be powerful tools for identifying individual quantitative trait loci, exploring hypotheses related to gene-environment interplay in human disease, and doing controlled exposure studies to understand the differential responses in humans to environmental exposures. This two-day meeting will allow many investigators to present research on a range of environmental health projects that have utilized these population-based rodent resources and highlight their utilities.
The meeting booklet (1MB) contains the final meeting agenda, poster list, poster abstracts, presentation abstracts, speaker bios, and participant list.
Materials for Meeting Attendees
Welcoming Remarks (305KB), Linda Birnbaum, National Institute of Environmental Health Sciences
Introduction/Purpose/Background (314KB), Kim McAllister, National Institute of Environmental Health Science
Session One: Overview of Mouse/Rat Resources
The Collaborative Cross: What We’ve Learned from Randomized, Structured Populations (3MB), David Threadgill, Texas A&M University
Diversity Outbred (12MB), Gary Churchill, Jackson Laboratory
Hybrid Diversity Panel (3MB), Brian Parks (Jake Lusis’ laboratory), University of California, Los Angeles
Recombinant Inbred Rats: Genetics, Transcriptomes, and Use for Identifying Phenotypic Determinants (2MB), Boris Tabakoff, University of Colorado School of Medicine
Session Two: Diverse Applications
“Fit-For-Purpose,” Population Study Designs to Address Specific Hypotheses (4MB), Ivan Rusyn, Texas A&M University
Mouse Populations Enable Translational Pharmacogenomic Approaches for Understanding and Predicting Adverse Drug Events (2MB), Alison Harrill, University of Arkansas for Medical Sciences
Identifying G X E Interactions and Thresholds for Toxicity in Diversity Outbred Mice (3MB), Jef French, National Institute of Environmental Health Sciences
A Diversity Outbred ES Cell Platform for In Vitro Genetics (2MB), Ted Choi, Predictive Biology, Inc.
Session Four: Computational Tools and Analysis Approaches
Advancing Risk Assessment with Population-Based Experimental Resources (1MB), Weihsueh Chiu, Texas A&M University
Mixed Model and Meta-analysis Methods for G X E Analysis in Mouse Studies (2MB), Eleazar Eskin, University of California, Los Angeles
Computational Mapping Tools (2MB), Dan Gatti, Jackson Laboratory
Session Five: Disease Applications
Genetic Regulatory Variation and Environmental Response (922KB), David Aylor, North Carolina State University
Harnessing Diversity in the CC and DO Populations for the Study of Behavior (3MB), Elissa Chesler, Jackson Laboratory
Genetic Diversity in Ebola Response (1MB), Martin Ferris, University of North Carolina, Chapel Hill
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