November 3-4, 2014
Research Triangle Park, NC

Parkinson's Conference Program Meeting and Recommendations Report (137KB)
Meeting Description
The overall goal of this two-day event was to develop prioritized recommendations for advancing basic, epidemiological and clinical research on environmental contributors to the development and expression of Parkinson's disease (PD). To accomplish this aim, the conference brought together experts to evaluate the most recent research on the environmental impact on PD etiology and discuss the challenges of translating research findings to impact public health. The format of the meeting agenda consisted of three inter-related parts:
- Basic, epidemiological and clinical scientists presented emerging themes and discussed prioritized research recommendations involving environmental contributors to PD.
- Panelists discussed the challenges and opportunities for interdisciplinary research approaches in advancing research on PD and environment.
- PD patients, patient advocates, physician scientists and research funders shared their perspectives on communicating and acting on science linking environmental exposures and PD.
This meeting offered numerous opportunities for participants (via webcast or in-person) to share ideas and help further stimulate research on the interaction between environmental exposures and genetic susceptibility in the development of PD.
- Program Book (648KB)
Meeting Sponsors
- National Institute of Environmental Health Sciences (NIEHS)
- National Institute of Neurological Disorders and Stroke (NINDS)
Agenda
Monday, November 3, 2014 | |
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8:30 a.m. | Registration |
9:00 a.m. | Welcome Linda Birnbaum, Director, NIEHS Walter Koroshetz, NINDS |
9:25 a.m. | Review of NINDS Workshop Recommendations Beth-Anne Sieber, NINDS |
9:35 a.m. | Goals for Meeting Jonathan Hollander, NIEHS |
Session 1: Clinical and Epidemiology Workgroup: Themes and Recommendations | |
9:45 a.m. | Overview of Themes Caroline Tanner, University of California, San Francisco |
10:00 a.m. | THEME 1: Opportunities to Identify Environmental Factors Affecting Prodromal PD
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10:25 a.m. | Break |
10:40 a.m. | THEME 2: Opportunities to Identify Environmental Factors Influencing Disease Progression After Diagnosis
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11:05 a.m. | THEME 3: Opportunities to Identify Biomarkers (Exposure, Diagnosis, Progression)
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11:30 a.m. | THEME 4: Opportunities to Identify Risk Factors
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11:55 a.m. | Summary and Recommendations Marc Weisskopf, Harvard University |
12:05 p.m. | Open Discussion of Priority and Content Caroline Tanner, University of California, San Francisco Marc Weisskopf, Harvard University |
12:30 p.m. | Lunch, NIEHS Cafeteria |
1:30 p.m. | Public Comment |
Session 2: Basic and Mechanistic Workgroup: Themes and Recommendations | |
2:00 p.m. | Overview of Themes Importance of systematic and unbiased analysis of environmental chemicals Gary Miller, Emory University |
2:20 p.m. | THEME 1: Impact of environmental chemicals on known genetic abnormalities in Parkinson's disease (alpha-synuclein, LRRK2, DJ-1, PINK1). Appropriate in vitro and in vivo models. David Standaert, University of Alabama-Birmingham Matthew Farrer, University of British Columbia |
2:45 p.m. | THEME 2: Impact of environmental chemicals on known Parkinson's disease pathways (mitochondria, protein processing, synaptic biology). Appropriate in vitro and in vivo models. John Elsworth, Yale University Richard Myers, Boston University Jau-Shyong Hong, NIEHS |
3:15 p.m. | Break |
3:25 p.m. | THEME 3: Measuring environmental chemicals in human and animal samples. Sampling, archiving, testing, and data analysis. Jeff Johnson, University of Wisconsin Anumantha Kanthasamy, Iowa State University |
3:50 p.m. | Summary and Presentation of Initial Prioritization of Recommendations Identifying and using the most appropriate model systems to study Parkinson's disease pathways and targets with broad sharing of experimental data Michael Lee, University of Minnesota |
4:05 p.m. | Open Discussion of Priority and Content Gary Miller, Emory University Michael Lee, University of Minnesota |
4:45 p.m. | Day 1 Summary and Closing Comments Cindy Lawler, NIEHS |
5:00 p.m. | Adjourn for the day; buses back to hotel |
6:30 p.m. | Dinner (Page Road Grill) |
Tuesday, November 4, 2014 | |
8:00 a.m. | Registration |
Session 3: Panel Discussion: Integrating Parkinson's Disease Environmental Research Across Disciplines | |
8:45 a.m. |
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10:00 a.m. | Break |
Session 4: Panel Discussion: Translation of Basic and Clinical Findings to Practice and Policy | |
10:15 a.m. |
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11:45 a.m. | Concluding Remarks Gwen Collman, NIEHS |
12:00 p.m. | Adjourn |
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