11/29/05 
ORIOGEN Version 2.2 Release Notes

	1)	The test statistic used in calculating the p-value has been changed to 
		be more appropriate for unbalanced input data (i.e. where the number of 
		samples at each time point is not constant). For more information
		on the updated test statistic, view the Help - About screen in ORIOGEN.

		NOTE: Due to this change, the list of genes selected by ORIOGEN may be different 
		when compared with previous versions.

	2)	In addition to the usual output file, there is now a second file saved by ORIOGEN that
		shows the individual raw data values for those genes that were identified to be significant
		by ORIOGEN.

	3)	There is now an option in the Inputs screen to take the log of the signal before doing any
		order-restricted analysis.


8/18/05 
ORIOGEN Version 2.1 Release Notes

	1)	Added q-value calculation to results output.

	2)	Added tutorial section to ReadMe.txt file.


5/10/05
ORIOGEN Version 2 Release Notes

Several enhancements have been made to ORIOGEN 1.0.  Some examples are:

	1) 	Ability to detect cyclic profiles with a single period.

	2) 	Improved graphical display of results.

	3)	The fitted and raw means are now written to a single output file.

	4) 	The standard errors at each dose/time point are now included in the output file.

	5)	The output file now includes header information, such as the file names, p-values, 
		and profile selections.

	6) 	Output file can also be accessed directly from the Results Viewer screen by using 
		the View - Summary Statistics menu option. 
		(NOTE: This feature is available only on the Windows platform). 
		The program used to open the output file depends on the output file 
		extension -- the default text viewer will be used for ".txt" files, and the 
		default spreadsheet program will be used for ".xlt" files.

	7)	Missing values denoted by a single period (".") are now allowed in the input file 
		provided there is at least two non-missing values at each dose/time point.

	8) 	Errors in the input file (such as lines that are improperly formatted) are 
		now recorded in an Error log file. If errors are encountered, the name of the 
		error log file is displayed upon the conclusion of the gene selection process.
