Department of Health and Human Services
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Division of National Toxicology Program (DNTP)
In Vitro Disease Modeling in Toxicology
Research Triangle Park, North Carolina
The Division of the National Toxicology Program (DNTP) at National Institute of Environmental Health Sciences (NIEHS), which is part of National Institutes of Health (NIH), seeks a postdoctoral trainee who wants to build their career in toxicological sciences to better understand how factors in our environment may impact our health. The DNTP’s mission is to improve public health through data and knowledge development that are translatable, predictive, and timely. DNTP strives to conduct innovative and rigorous toxicology research that aligns with real-world public health needs and to translate scientific findings into knowledge that can inform real-life individual and public health concerns. The DNTP functions as a team-based research organization conducting research that is integrated across the Division. Much of DNTP’s work is in support of the interagency National Toxicology Program.
A postdoctoral position is available in the Mechanistic Toxicology Branch (MTB) of the DNTP at NIEHS, Research Triangle Park, North Carolina. The goal of this project is to investigate the role of environmental chemical exposures on the onset or exacerbation of the severity or progression of cardiovascular diseases. Likewise, pre-existing disease states that represent a significant risk factor for environmental exposures will be studied. Human relevant new approach methodologies (NAMs) will be used to model fundamental elements of common cardiovascular and metabolic diseases to determine how environmental exposures modify those conditions with an aim to understand how they might exacerbate clinical disease. This project will develop novel approaches to hazard assessment that directly support our Health Effects Innovation (HEI) programs at the DNTP. The candidate will have an opportunity to work with a multi-disciplinary team of scientists gaining broad perspective on traditional hazard assessment and contributing to novel approaches in predictive toxicological assessment. DNTP has state-of-the-art laboratory and toxicology testing facilities. The postdoctoral fellow will be co-mentored by Sreenivasa Ramaiahgari, Ph.D., and Brian Berridge, Ph.D..
Main Activities of the Candidate:
- Develop novel in vitro disease models to study key pathophysiological elements of common cardiovascular and metabolic diseases.
- Evaluate common environmental exposures in disease models and quantify how the disease condition is modified.
- Work with multi-disciplinary team of scientists involved in data mining and in silico approaches and screen predicted bioactive chemicals using in vitro methods.
- Study molecular mechanism leading to pathophysiology of the disease upon exposures to environmental stressors.
- Develop and validate new approach methodologies (NAMs) for cardiovascular diseases models.
- Publish in peer-reviewed journals and present research work at national meetings.
Scientific Knowledge and Skills:
- Knowledge in cardiovascular biology.
- Experience with basic cell culture (iPSC technology desirable) and molecular biology.
- Experience with next generation in vitro models (Organoid/microphysiological systems), high-content imaging systems is preferred.
- Data analysis and excellent record documentation.
- Team player with good oral communication and writing skills.
Eligibility and Benefits:
Applicants must have an advanced degree (Ph.D., D.V.M., M.D., or equivalent) within 5 years at the start of fellowship. The DNTP postdoctoral training program funds fellowships for up to three years. Stipends are commensurate to experience. Postdoctoral fellows are considered as professionals-in-training and are not classified as NIH employees. Medical insurance is provided. More details about the fellowships can be found on NIH post-doctoral fellowships.
NIH/NIEHS encourages the application and nomination of qualified women, minorities, and individuals with disabilities. All applicants will receive consideration without regard to race, color, religion, sex, national origin, age, protected veteran status, disability status, sexual orientation, gender identity or any other non-merit factor.
Applications should be submitted as a single pdf including:
- Curriculum Vitae.
- A one-page cover letter describing research background and career aspirations.
- Names and contact information of three references.
Please submit your application to Sreenivasa Ramaiahgari, Ph.D. via email with the subject line: Postdoc Fellow Application - First and Last name of the applicant.