Department of Health and Human Services
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Division of National Toxicology Program (DNTP)
Research Triangle Park, North Carolina
A postdoctoral position is immediately available in the Mechanistic Toxicology Branch (MTB) in the Division of the National Toxicology Program (DNTP) at the National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina. The project aims at establishing whether mitochondrial reserve capacity is a target of environmental exposures that can contribute to human disease, specifically, cardiovascular disease (CVD). These studies support a new Cardiovascular Health Effects Initiative of the DNTP that aims at understanding the contribution of environmental exposures to common cardiovascular diseases. The work will initially involve the use of in vitro 2D and 3D rodent and human cardiomyocyte models and will eventually expand in vivo. Detailed mechanisms will be explored with a combination of biochemistry and genomics approaches. The successful candidate will have a strong background in cardiovascular studies, including in the use of cardiomyocyte cultures (e.g. primary and immortalized cells as well as iPSC-derived cardiomyocytes) and animal models. The candidate will be versed in cell imaging-based techniques, including calcium imaging and functional assessment of cardiomyocyte function using microelectrode arrays. Knowledge of mitochondrial metabolism is strongly desired. Experience with deep sequencing techniques (library preparation and data analysis) is desirable but not required. The candidate will have access to state-of-the-art equipment, including the Seahorse flux analyzer, the Opera phenix high content imager confocal microscope and the Maestro Pro microelectrode impedance-based array. Strong communication and written skills are desired and ability to work as part of a team is a must.
The DNTP postdoctoral training program typically funds fellowships for three years. Stipends are commensurate to experience. Postdoctoral fellows are considered as professionals-in-training and are not classified as NIH employees. Medical insurance is provided. The position is immediately available and will be open until filled.
- Doctoral degree in biochemistry, physiology, or closely related discipline.
- Experience in in vitro cardiomyocyte cultures and analysis of cardiovascular function both in vitro and in vivo.
- Knowledge of mitochondrial function desirable.
Interested candidates with required experience should send a single PDF containing a cover letter indicating experience and research interests, CV and three reference letters to Janine H. Santos, Ph.D.