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Cryo-electron Microscopy Core Deputy Manager, Genome Integrity & Structural Biology Laboratory

Department of Health and Human Services
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Division of Intramural Research
Research Triangle Park, North Carolina
Cryo-electron Microscopy Core Deputy Manager, Genome Integrity & Structural Biology Laboratory

The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health (NIH), is seeking a candidate to fill the position of Staff Scientist Core Deputy Manager for the Cryo-electron Microscopy (Genome Integrity & Structural Biology Laboratory) Core facility. The NIEHS is located in the Research Triangle Park (RTP), a world-renowned academic research center in North Carolina and an area well known for its high quality of life.

Core facilities are centralized shared research resources that provide access to instruments, technologies, and services as well as expert consultation to scientific and clinical investigators within the Institute. The typical core facility is a discrete unit and has dedicated personnel, equipment, and space for operations.

Vacancy #NR126: Cryo-electron Microscopy Core Deputy Manager, Staff Scientist - The Cryo-electron Microscopy (Cryo-EM) Core collaborates with intramural research groups to solve the structure of biological macromolecules and complexes to better understand their function and treat diseases. The Cryo-EM Core Deputy Manager will work with the Core Manager and staff to facilitate the use of the Cryo-EM facility by NIEHS scientists. The Cryo-EM Core Deputy Manager must also maintain state-of-the-art knowledge of the field, assist the Manager in supervising personnel, and in the daily operation of the Core.

Qualifications: Applicants should have a Ph.D., M.D. and/or equivalent doctoral degree with at least 3 years of postdoctoral research/or equivalent experience in their field such that they have a total of at least 5 years of experience using with state-of-the-art high resolution cryo-EM microscopes. In particular, applicants should have experience using instruments with automated or semi-automated multi-specimen loading systems and experience in optimization of specimen preparation and data collection for high resolution single particle cryo-EM (experience with automated vitrification systems will be considered a definitive plus). They should be capable of independently designing experiments, and have demonstrated experience and expertise, as documented by peer-reviewed publications, in determining structures of macromolecular complexes at near atomic resolution using single particle cryo-EM. Applicants should have good people skills with experience training individuals at the post-doctoral, graduate and undergraduate level, and be able to train staff and scientists in cryo-EM fundamentals and equipment operation through workshops, journal clubs, and informal interactions; and be skilled in preparing scientific presentations and publications. Applications from women and under-represented minorities are strongly encouraged. Appointees may be U.S. citizens, resident aliens, or non-resident aliens with, or eligible to obtain, a valid employment-authorization visa.

Salary/Benefits: The successful candidate for this position will be appointed at a salary commensurate with experience and accomplishments with full Federal benefits, including leave, health and life insurance, retirement, and savings plan (401K equivalent).

Equal Opportunity Employment: Selection for this position will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. The NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

Foreign Education: Applicants who have completed part or all of their education outside of the United States must provide an evaluation by an accredited organization to ensure its equivalence to education received in accredited educational institutions in the United States. For more information on foreign education verification, visit the National Association of Credential Evaluation Services (NACES) website. Verification must be received prior to the effective date of the appointment.

Reasonable Accommodation: NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis.

How to Apply: Applications for this position will be accepted April 19, 2021 through May 19, 2021. Interested candidates should submit their curriculum vitae and a two-page statement of research interests and goals, as ONE (1) combined PDF to the Division of Intramural Research Search Committee at The application materials should describe the candidate’s experience in the specific areas listed in the respective position description above. Please include your name and the proper vacancy number NR126 in the subject line of your email submission. In addition, applicants must arrange to have THREE (3) reference letters sent to Please be sure referees include your name and the proper vacancy number (#NR126) in the subject line of their email. For further information about the position, please contact Mario J. Borgnia.

The NIH is the premier biomedical research center for the world. Its 27 institutes and centers employ more than 21,000 employees doing a vast array of jobs, all supporting efforts for a healthy nation. For information about the NIH mission, goals and institutes and centers, visit About NIH.

Do not include your birth date, photograph, or social security number (SSN) on application materials. DHHS and NIH are equal opportunity employers.

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