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Your Environment. Your Health.

Selected Scientific Advances

2012 - 2017 Strategic Plan

Citation Year Goal
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P.Mol Cell. 2015 Jul 16;59(2):176-87. Epub 2015 Jul 2. [Abstract] 2015 Goal 1
NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Chrysovergis K (DIR), X Wang (DIR), J Kosak (DIR), SH Lee, J Sik Kim (DIR), JF Foley (NTP), G Travlos (NTP), S Singh (DIR), S Joon Baek and TE Eling(DIR). Int J Obes (Lond) (2014) InPress. [Abstract] 2014 Goal 1
Mitochondria, energetics, epigenetics, and cellular responses to stress. Shaughnessy DT (DERT), McAllister K (DERT), Worth L (DERT), Haugen AC (DERT), Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC (NTP), Tice RR (NTP), Balshaw DM (DERT), Tyson FL (DERT). Environ Health Perspect. 2014 Dec;122(12):1271-8. [Abstract] 2014 Goal 1
Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis. Gosavi RA (DIR), Knudsen GA, Birnbaum LS (OD), Pedersen LC (DIR). Environ Health Perspect. 2013 Oct;121(10):1194-9. doi: 10.1289/ehp.1306902. Epub 2013 Aug 13. [Abstract] 2014 Goal 1
Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Liu C, Peng J, Matzuk MM, Yao HH (DIR). Nat Commun. 2015 Apr 28;6:6934. [Abstract] 2015 Goal 1
Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy. Markunas CA (DIR), Xu Z (DIR), Harlid S (DIR), Wade PA (DIR), Lie RT, Taylor JA (DIR), Wilcox AJ (DIR). Environ Health Perspect. 2014 Jun 6. [Epub ahead of print] [Abstract] 2014 Goal 1
Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study Deroo LA, SC Bolick, Z Xu, DM Umbach, D Shore, CR Weinberg, DP Sandler and JA Taylor [Journal article] Carcinogenesis (2013 Nov 23) [ePub] [Abstract] 2014 Goal 1
Essential role of Orai1 store-operated calcium channels in lactation. Davis FM (DIR), A Janoshazi (DIR), KS Janardhan, N Steinckwich (DIR), DM D'Agostin (DIR), JG Petranka (DIR), PN Desai (DIR), SJ Roberts-Thomson, GS Bird (DIR), DK Tucker (NTP), SE Fenton (NTP), S Feske, GR Monteith and JW Putney, Jr. (DIR). Proc. Natl. Acad. Sci. U. S. A. (2015) [ePub] [Abstract] 2015 Goal 1
Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain. Tyler CR, Hafez AK, Solomon ER, Allan AM. Toxicol Appl Pharmacol. 2015 Jul 17;288(1):40-51. [Epub ahead of print] [Abstract] 2015 Goal 1
Development of Phenotypic and Transcriptional Biomarkers to Evaluate Relative Activity of Potentially Estrogenic Chemicals in Ovariectomized Mice. Hewitt SC (DIR), W Winuthayanon (DIR), B Pockette (DIR), RT Kerns (DIR), JF Foley (NTP), N Flagler (NTP), E Ney (NTP), A Suksamrarn, P Piyachaturawat, PR Bushel (DIR) and KS Korach(DIR). Environ. Health Perspect. (2015) v. 123 (4): pp. 344-352 [Abstract] 2015 Goal 1
Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library. Chen S, JH Hsieh (NTP), R Huang, S Sakamuru, LY Hsin, M Xia, KR Shockley (DIR), S Auerbach (NTP), N Kanaya, H Lu, D Svoboda (NTP), KL Witt (NTP), BA Merrick (NTP), CT Teng (NTP) and RR Tice (NTP). Toxicol. Sci. (2015) [Abstract] 2015 Goal 1
Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese S, Markunas CA, Richmond RC, Xu C-J, Kupers LK, Oh SS, Hoyo C, Gruzieva O, Soderhall C, Salas LA, Baiz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Haberg SE, Xu Z, van Meurs JB, Gant TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergstrom A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles M-A, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert M-F, Eskenazi B, Vrijheid M, Arshad H, Anto JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchand EG, Ladd-Acosta C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VWV, Wilcox A, Melen E, London SJ. 2016. DNA methylation in newborns and maternal smoking in pregnancy: Genome-wide consortium meta-analysis. Am J Hum Genet; doi:10.1016/j.ajhg.2016.02.019 [Online 30 March 2016]. [Abstract] 2015 Goal 1
Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Behl, M (DNTP), Hsieh, JH, Shafer, TJ, Mundy, WR, Rice, JR (DNTP), Boyd, WA (DNTP), Freedman, JH (DNTP-former), Hunter, ES, 3rd, Jarema, K, Padilla, S (DNTP), Tice, RR (DNTP). Neurotoxicol Teratol. 2015. [Abstract] 2015 Goal 1
Genomic profiling reveals unique molecular alterations in hepatoblastomas and adjacent hepatocellular carcinomas in B6C3F1 mice. Bhusari, S, Pandiri, AR (DNTP), Nagai, H, Wang, Y, Foley, J (DNTP), Hong, HL (DNTP), Ton, TV (DNTP), DeVito, M (DNTP), Shockley, KR, Peddada, SD, Gerrish, KE, Malarkey, DE (DNTP), Hooth, MJ (DNTP), Sills, RC (DNTP), Hoenerhoff, MJ (DNTP). Toxicol Pathol. 2015. [Abstract] 2015 Goal 1
LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells. Yang J(DIR), Bennett BD(DIR), Luo S, Inoue K(DIR), Grimm SA(DIR), Schroth GP, Bushel PR(DIR), Kinyamu HK(DIR), Archer TK (DIR). Mol Cell Biol. 2015 Sep;35(18):3225-43. [Abstract] 2015 Goal 1
Capturing snapshots of APE1 processing DNA damage. Freudenthal BD (DIR), Beard WA (DIR), Cuneo MJ, Dyrkheeva NS (DIR), Wilson SH (DIR).  Nat Struct Mol Biol. 2015 Nov;22(11):924-31. [Abstract] 2015 Goal 1
Developmental Effects of the ToxCast™ Phase I and II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. Boyd, WA (DNTP), Smith, MV, Co, CA, Pirone, JR, Rice, JR (DNTP), Shockley, KR, Freedman, JH (DNTP-former). Environ Health Perspect. 2015. [Abstract] 2015 Goal 1
Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Sen A, Heredia N, Senut MC, Land S, Hollocher K, Lu X, Dereski MO, Ruden DM. Sci Rep. 2015 Sep 29;5:14466. [Abstract] 2015 Goal 1
Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 2. Sex-specific neuromolecular effects in the brain. Bell MR, Hart BG, Gore AC. Mol Cell Endocrinol. 2016 Jan 15;420:125-37. [Abstract] 2016 Goal 1
DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy. Reese SE (DIR), S Zhao (DIR), MC Wu, BR Joubert (DERT), CL Parr (DIR), SE Haberg, PM Ueland, RM Nilsen, O Midttun, SE Vollset, SD Peddada (DIR), W Nystad and SJ London (DIR). Environ Health Perspect (2016) [InPress] [Abstract] 2016 Goal 1
The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. Kang HS (DIR), Y Takeda (DIR), K Jeon (DIR) and AM Jetten (DIR). PLoS One (2016) v. 11 (6): pp. e0157138 [Abstract] 2016 Goal 1
Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults. Markunas CA (DIR), AJ Wilcox (DIR), Z Xu (DIR), BR Joubert (DIR), S Harlid (DIR), V Panduri (DIR), SE Haberg, W Nystad, SJ London (DIR), DP Sandler (DIR), RT Lie, PA Wade (DIR) and JA Taylor (DIR). PLoS ONE (2016) v. 11 (7): pp. e0156361 [Abstract] 2016 Goal 1
Transcription Factor GLIS3: a New and Critical Regulator of Postnatal Stages of Mouse Spermatogenesis. Kang HS (DIR), LY Chen (DIR), K Lichti-Kaiser (DIR), G Liao (DIR), K Gerrish (DIR), CD Bortner (DIR), HH Yao (DIR), EM Eddy (DIR) and AM Jetten (DIR). Stem Cells (2016) [Abstract] 2016 Goal 1
Regions of variable DNA methylation in human placenta associated with newborn neurobehavior. Paquette AG, Houseman EA, Green BB, Lesseur C, Armstrong DA, Lester B, Marsit CJ. Epigenetics. 2016 Aug 2;11(8):603-13. [Abstract] 2016 Goal 1
Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions. Krakowiak P, Walker CK, Tancredi D, Hertz-Picciotto I, Van de Water J. Autism Res. 2016 Jun 17. [Abstract] 2016 Goal 1
Selfish drive can trump function when animal mitochondrial genomes compete. Ma H, O'Farrell PH. Nat Genet. 2016 Jul;48(7):798-802. [Abstract] 2016 Goal 1
Chemical reactivity and respiratory toxicity of the alpha-diketone flavoring agents: 2,3-butanedione, 2,3-pentanedione, and 2,3-hexanedione. Morgan, DL (DNTP), Jokinen, MP, Johnson, CL, Price, HC, Gwinn, WM (DNTP), Bousquet, RW, Flake, GP (DNTP). Toxicol Pathol. 2016. [Abstract] 2016 Goal 1
Subchronic exposures to fungal bioaerosols promotes allergic pulmonary inflammation in naive mice. Nayak, AP, Green, BJ, Lemons, AR, Marshall, NB, Goldsmith, WT, Kashon, ML, Anderson, SE, Germolec, DR (DNTP), Beezhold, DH. Clin Exp Allergy. 2016. [Abstract] 2016 Goal 1
Histology atlas of the developing mouse hepatobiliary hemolymphatic vascular system with emphasis on embryonic days 11.5-18.5 and early postnatal development. Swartley, OM, Foley, JF (DNTP), Livingston, DP, 3rd, Cullen, JM, Elmore, SA (DNTP). Toxicol Pathol. 2016. [Abstract] 2016 Goal 1
Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Schellenberg MJ (DIR), L Perera (DIR), CN Strom, CA Waters, B Monian (DIR), CD Appel (DIR), CK Vilas (DIR), JG Williams (DIR), DA Ramsden and RS Williams (DIR). Nucleic Acids Res (2016) [ePub] [Abstract] 2016 Goal 1
Skeletal muscle action of estrogen receptor alpha is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Ribas V, BG Drew, Z Zhou, J Phun, NY Kalajian, T Soleymani, P Daraei, K Widjaja, J Wanagat, TQ de Aguiar Vallim, AH Fluitt, S Bensinger, T Le, C Radu, JP Whitelegge, SW Beaven, P Tontonoz, AJ Lusis, BW Parks, L Vergnes, K Reue, H Singh, JC Bopassa, L Toro, E Stefani, MJ Watt, S Schenk, T Akerstrom, M Kelly, BK Pedersen, SC Hewitt (DIR), KS Korach (DIR) and AL Hevener. Sci. Transl. Med. (2016) v. 8 (334): pp. 334ra54. [Abstract] 2016 Goal 1
Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children. Huen K, Calafat AM, Bradman A, Yousefi P, Eskenazi B, Holland N. Environ Res. 2016 Mar 25;148:55-62. [Abstract] 2016 Goal 1
Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis. Maertens A, Bouhifd M, Zhao L, Odwin-DaCosta S, Kleensang A, Yager JD, Hartung T. Arch Toxicol. 2016 Apr 2. [Epub ahead of print] [Abstract] 2016 Goal 1
Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts. Gassman NR (DIR), E Coskun, P Jaruga, M Dizdaroglu and SH Wilson (DIR). Environ Health Perspect (2016) [InPress] [Abstract] 2016 Goal 1
Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high- throughput screen for developmental neurotoxicity or neurotoxicity. Ryan, KR (DNTP), Sirenko, O, Parham, F (DNTP), Hsieh, JH (DNTP), Cromwell, EF, Tice, RR (DNTP), Behl, M (DNTP). Neurotoxicology. 2016. [Abstract] 2016 Goal 1
Haploinsufficiency of SIRT1 Enhances Glutamin Metabolism and Promotes Cancer Development. Ren NS (DIR), M Ji (DIR), EJ Tokar (NTP), EL Busch, X Xu (DIR), D Lewis (DIR), X Li, A Jin, Y Zhang, WK Wu, W Huang (DIR), L Li (DIR), DC Fargo (DIR), TO Keku, RS Sandler and X Li (DIR). Curr Biol (2017) v.27 (4): pp. 483-494. [Abstract] 2017 Goal 1
In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning. Zang Q, K Mansouri, AJ Williams, RS Judson, DG Allen, WM Casey (DNTP) and NC Kleinstreuer (DNTP).  J. Chem. Inf. Model. (2017) v. 57 (1): pp. 36-49. [Abstract] 2017 Goal 1
DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Gao L, Mutlu E (DNTP), Collins LB, Walker NJ (DNTP), Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. Chem Res Toxicol. 2017 Mar 20;30(3):794-803. [Abstract] 2017 Goal 1
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Shaw ND (DIR), H Brand, ZA Kupchinsky, H Bengani, L Plummer, TI Jones, S Erdin, KA Williamson, J Rainger, A Stortchevoi, K Samocha, BB Currall, DS Dunican, RL Collins, JR Willer, A Lek, M Lek, M Nassan, S Pereira, T Kammin, D Lucente, A Silva, CM Seabra, C Chiang, Y An, M Ansari, JK Rainger, S Joss, JC Smith, MF Lippincott, SS Singh, N Patel, JW Jing, JR Law, N Ferraro, A Verloes, A Rauch, K Steindl, M Zweier, I Scheer, D Sato, N Okamoto, C Jacobsen, J Tryggestad, S Chernausek, LA Schimmenti, B Brasseur, C Cesaretti, JE Garcia-Ortiz, TP Buitrago, OP Silva, JD Hoffman, W Muhlbauer, KW Ruprecht, BL Loeys, M Shino, AM Kaindl, CH Cho, CC Morton, RR Meehan, V van Heyningen, EC Liao, R Balasubramanian, JE Hall (DIR), SB Seminara, D Macarthur, SA Moore, KI Yoshiura, JF Gusella, JA Marsh, JM Graham, Jr., AE Lin, N Katsanis, PL Jones, WF Crowley, Jr., EE Davis, DR FitzPatrick and ME Talkowski. Nat. Genet. (2017) v. 49 (2): pp. 238-248. [Abstract] 2017 Goal 1
Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Caglayan M (DIR), JK Horton (DIR), DP Dai (DIR), DF Stefanick (DIR) and SH Wilson (DIR). Nature communications (2017) v. 8:14045. [Abstract] 2017 Goal 1
APE2 Zf-GRF facilitates 3’-5’ resection of DNA damage following oxidative stress. Wallace BD (DIR), Z Berman, GA Mueller (DIR), Y Lin, T Chang (DIR), SN Andres (DIR), JL Wojtaszek (DIR), EF DeRose (DIR), CD Appel (DIR), RE London (DIR), S Yan and RS Williams (DIR). Proc Natl Acad Sci (2017) v. 114 (2) pp. 304-309. [Abstract] 2017 Goal 1
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. Williams CJ (DIR), A Chu, WN Jefferson (DIR), D Casero, D Sudhakar, N Khurana, CP Hogue, C Aryasomayajula, P Patel, P Sullivan, E Padilla-Banks (DIR), S Mohandessi, C Janzen and M Wadehra. J Pathol (2017). [Abstract] 2017 Goal 1
Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Seok SH, W Lee, L Jiang, K Molugu, A Zheng, Y Li, S Park, CA Bradfield and Y Xing. Proc Natl Acad Sci (2017) Apr 10. [Abstract] 2017 Goal 1
Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity. Cisse YM, Russart KL, Nelson RJ. Sci Rep. 2017 Mar 31;7:45497. [Abstract] 2017 Goal 1
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Xiao S, JR Coppeta, HB Rogers, BC Isenberg, J Zhu, SA Olalekan, KE McKinnon, D Dokic, AS Rashedi, DJ Haisenleder, SS Malpani, CA Arnold-Murray, KW Chen, MY Jiang, L Bai, CT Nguyen, JY Zhang, MM Laronda, TJ Hope, KP Maniar, ME Pavone, MJ Avram, EC Sefton, S Getsios, JE Burdette, JJ Kim, JT Borenstein and TK Woodruff. Nature communications (2017) v. 8. [Abstract] 2017 Goal 1
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN. Nat Commun. 2017 May 16;8:15261. [Abstract] 2017 Goal 1
Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes. Ferrucio B, M Tiago, RD Fannin (DIR), L Liu (DIR), K Gerrish (DIR), SS Maria-Engler, RS Paules (NTP) and SB de Moraes Barros. Toxicol In Vitro (2016). [Abstract] 2016 Goal 1
Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure. Stanko JP (NTP), GE Kissling (DIR), VA Chappell (NTP) and SE Fenton (NTP). Toxicol. Pathol. (2016) v. 44 (7): pp. 1021-33. [Abstract] 2016 Goal 1
Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Behl M (DNTP), JR Rice (DNTP), MV Smith, CA Co, MF Bridge, J-H Hsieh (DNTP), JH Freedman and WA Boyd (DNTP). Toxicol Sci. 2016 Dec;154(2):241-252. [Abstract] 2016 Goal 1
Integrated decision strategies for skin sensitization hazard. Strickland J, Zang Q, Kleinstreuer N (DNTP), Paris M, Lehmann DM, Choksi N, Matheson J, Jacobs A, Lowit A, Allen D, Casey W (DNTP). J Appl Toxicol 36(9):1150–1162. [Abstract] 2016 Goal 1
Development and Validation of a Computational Model for Androgen Receptor Activity. Kleinstreuer NC (DNTP), Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM (DNTP), Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R. Chem Res Toxicol. 2016 Dec 9. [Abstract] 2016 Goal 1
A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Rubel CA, SP Wu (DIR), L Lin, T Wang (DIR), RB Lanz, X Li, R Kommagani, HL Franco, SA Camper, Q Tong, JW Jeong, JP Lydon and FJ DeMayo (DIR). Cell reports (2016) v. 17 (5): pp. 1414-1425. [Abstract] 2016 Goal 1
Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA. Zhang J (DIR), McCann KL (DIR), Qiu C (DIR), Gonzalez LE (DIR), Baserga SJ, Hall TM (DIR). Nat Commun 2016 7:13085. [Abstract] 2016 Goal 1
INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer. Zhang S, Zhou B (DIR), Wang L (DIR), Li P (DIR), Bennett BD (DIR), Snyder R (DIR), Garantziotis S (DIR), Fargo DC (DIR), Cox AD, Chen L, Hu G (DIR). Oncogene 2016 Sep 19. [Abstract] 2016 Goal 1
MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains. Lai L (DIR), Azzam KM (DIR), Lin WC (DIR), Rai P (DIR), Lowe JM (DIR), Gabor KA (DIR), Madenspacher JH (DIR), Aloor JJ (DIR), Parks JS, Naar AM, Fessler MB (DIR). J Biol Chem 2016. 291(37):19651−19660. [Abstract] 2016 Goal 1
Mapping lineage progression of somatic progenitor cells in the mouse fetal testis. Liu C (DIR), Rodriguez K (DIR), Yao HH (DIR). Development 2016 Oct 15;143(20):3700-3710. [Abstract] 2016 Goal 1
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Reid NM, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci D, Oleksiak MF, Crawford DL, Whitehead A. Science Dec 9 2016; 354(6317):1305-1308. [Abstract] 2016 Goal 1
Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Stem Cells. 2016 Dec 29. [Abstract] 2016 Goal 1
Oxidative guanine base damage regulates human telomerase activity. Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL. Nat Struct Mol Biol 2016 Dec; 23(12):1092–1100. [Abstract] 2016 Goal 1
Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Ho SM, Rao RC, To S, Schoch E, Tarapore P. Endocr Relat Cancer. 2016 Dec 20. [Abstract] 2016 Goal 1
An inducible long noncoding RNA amplifies DNA damage signaling. Schmitt AM, Garcia JT, Hung T, Flynn RA, Shen Y, Qu K, Payumo AY, Peres-da-Silva A, Broz DK, Baum R, Guo S, Chen JK, Attardi LD, Chang HY. Nat Genet. 2016 Nov;48(11):1370-1376. doi: 10.1038/ng.3673. [Abstract] 2016 Goal 1
Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes. Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. Cell Rep. 2016 Dec 13;17(11):3035-3048. [Abstract] 2016 Goal 1
Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk. Hewitt Fenton SE (NTP) and LS Birnbaum (OD). J. Clin. Endocrinol. Metab. (2015) v. pp. jc20152848 [Abstract] 2015 Goal 2
Secondhand Tobacco Smoke Exposure and Neuromotor Function in Rural Children. Yeramaneni S, Dietrich KN, Yolton K, Parsons PJ, Aldous KM, Haynes EN. J Pediatr. 2015 Apr 13. [Epub ahead of print] [Abstract] 2015 Goal 2
Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Salo PM (DIR), SJ Arbes, Jr., R Jaramillo, A Calatroni, CH Weir, ML Sever, JA Hoppin (DIR), KM Rose, AH Liu, PJ Gergen, HE Mitchell and DC Zeldin (DIR). J. Allergy Clin. Immunol. (2014) [InPress] [Abstract] 2014 Goal 2
Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study. Chen A, Yolton K, Rauch SA, Webster GM, Hornung R, Sjödin A, Dietrich KN, Lanphear BP. Environ Health Perspect. 2014 Aug;122(8):856-62. [Abstract] 2014 Goal 2
Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. PLoS One. 2013 May 29;8(5):e64128. doi: 10.1371/journal.pone.0064128. Print 2013. [Abstract] 2014 Goal 2
Prenatal exposure to organophosphate pesticides and reciprocal social behavior in childhood. Furlong MA, Engel SM, Barr DB, Wolff MS. Environ Int. 2014 Sep;70:125-31. [Abstract] 2014 Goal 2
Prenatal exposure to air pollution, maternal psychological distress, and child behavior. Perera FP, Wang S, Rauh V, Zhou H, Stigter L, Camann D, Jedrychowski W, Mroz E, Majewska R. Pediatrics. 2013 Nov;132(5):e1284-94. doi: 10.1542/peds.2012-3844. Epub 2013 Oct 7. [Abstract] 2014 Goal 2
Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study. Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I. Environ Health Perspect. 2014 Jun 23. [Abstract] 2014 Goal 2
NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Chrysovergis K (DIR), X Wang (DIR), J Kosak (DIR), SH Lee, J Sik Kim (DIR), JF Foley (NTP), G Travlos (NTP), S Singh (DIR), S Joon Baek and TE Eling(DIR). Int J Obes (Lond) (2014) InPress. [Abstract] 2014 Goal 2
Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? Stapleton PA, Minarchick VC, Yi J, Engels K, McBride CR, Nurkiewicz TR. Am J Obstet Gynecol. 2013 Sep;209(3):227.e1-11. doi: 10.1016/j.ajog.2013.04.036. Epub 2013 Apr 30. [Abstract] 2014 Goal 2
Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C. Environ Health Perspect. 2015 Jun 26. [Epub ahead of print] [Abstract] 2015 Goal 2
Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy. Markunas CA (DIR), Xu Z (DIR), Harlid S (DIR), Wade PA (DIR), Lie RT, Taylor JA (DIR), Wilcox AJ (DIR). Environ Health Perspect. 2014 Jun 6. [Epub ahead of print] [Abstract] 2014 Goal 2
Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. House, JS (DIR), Li, H (DIR), DeGraff, LM (DIR), Flake, G (NTP), Zeldin, DC (DIR) and London, SJ (DIR). FASEB J. (2014) [ePub]. [Abstract] 2015 Goal 2
Elevated serum pesticide levels and risk for Alzheimer disease. Richardson JR, Roy A, Shalat SL, von Stein RT, Hossain MM, Buckley B, Gearing M, Levey AI, German DC. JAMA Neurol. 2014 Mar;71(3):284-90. doi: 10.1001/jamaneurol.2013.6030. [Abstract] 2014 Goal 2
Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia. Stansfield KH, Ruby KN, Soares BD, McGlothan JL, Liu X, Guilarte TR. Transl Psychiatry. 2015 Mar 10;5:e522. [Abstract] 2015 Goal 2
Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8-14 years of age. Cantoral A, Téllez-Rojo MM, Ettinger AS, Hu H, Hernández-Ávila M, Peterson K. Pediatr Obes. 2015 Apr 17. [Epub ahead of print] [Abstract] 2015 Goal 2
Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity. French, JE (NTP), Gatti, DM, Morgan, DL (NTP), Kissling, GE (DIR), Shockley, KR (DIR), Knudsen, GA (OD), Shepard, KG, Price, HC, King, D (NTP), Witt, KL (NTP), Pedersen, LC (DIR), Munger, SC, Svenson, KL and Churchill, GA. Environ. Health Perspect. (2014)[ePub] [Abstract] 2015 Goal 2
Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain. Tyler CR, Hafez AK, Solomon ER, Allan AM. Toxicol Appl Pharmacol. 2015 Jul 17;288(1):40-51. [Epub ahead of print] [Abstract] 2015 Goal 2
Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury. Debes F, Weihe P, Grandjean P. Cortex. 2015 Jun 4. [Epub ahead of print] [Abstract] 2015 Goal 2
Breast Cancer Risk after Occupational Solvent Exposure: the Influence of Timing and Setting. Ekenga CC (DIR), CG Parks (DIR), AA D'Aloisio (DIR), LA DeRoo (DIR) and DP Sandler (DIR). Cancer Res. (2014) v. 74 (11): pp. 3076-3083. [Abstract] 2014 Goal 2
Blood lead concentrations and children's behavioral and emotional problems: A Cohort Study. Liu J, Liu X, Wang W, McCauley L, Pinto-Martin J, Wang Y, Li L, Yan C, Rogan WJ (DIR). JAMA Pediatr. 2014 Aug 1;168(8):737-45. [Abstract] 2014 Goal 2
Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer. Weinberg, CR, Shi, M, Deroo, LA, Taylor, JA, Sandler, DP and Umbach, DM. PLoS Genet (2014) v. 10 (3): pp. e1004174. [Abstract] 2014 Goal 2
Association of Nrf2 polymorphism haplotypes with acute lung injury phenotypes in inbred strains of mice. Cho, HY (DIR), Jedlicka, AE, Gladwell, W (DIR), Marzec, J (DIR), McCaw, ZR (DIR), Bienstock, R (DIR) and Kleeberger, SR (DIR). Antioxid Redox Signal (2014) [ePub] [Abstract] 2015 Goal 2
Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. Skinner MK, Manikkam M, Tracey R, Guerrero-Bosagna C, Haque M, Nilsson EE BMC Med 2013 Oct 23;11:228. doi: 10.1186/1741-7015-11-228. [Abstract] 2014 Goal 2
Ambient Air Pollution Exposure and Incident Adult Asthma in a Nationwide Cohort of U.S. Women. Young, MT, Sandler, DP (DIR), DeRoo, LA (DIR), Vedal, S, Kaufman, JD and London, SJ (DIR). Am. J. Respir. Crit. Care Med. (2014) [Abstract] 2015 Goal 2
Advancing research on endocrine disrupting chemicals in breast cancer: expert panel recommendations. Teitelbaum SL, Belpoggi F, Reinlib L. Reprod Toxicol. June 2015. 54:141-147. [Abstract] 2015 Goal 2
A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection. Ciencewicki, JM (DIR), Wang, X (DIR), Marzec, J (DIR), Serra, ME, Bell, DA (DIR), Polack, FP and Kleeberger, SR (DIR). FASEB J. (2014) [ePub]. [Abstract] 2014 Goal 2
Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Fannin RD (DIR), K Gerrish (DIR), SO Sieber (DIR), PR Bushel (DIR), PB Watkins and RS Paules (NTP). Clin. Pharmacol. Ther. (2015) [InPress] [Abstract] 2015 Goal 2
Overall and central adiposity and breast cancer risk in the Sister Study.  White AJ, Nichols HB, Bradshaw PT, Sandler DP (DIR). Cancer. 2015 Oct 15;121(20):3700-8. [Abstract] 2015 Goal 2
Soy-Based Infant Formula Feeding and Ultrasound-Detected Uterine Fibroids among Young African-American Women with No Prior Clinical Diagnosis of Fibroids. Upson K (DIR), Harmon QE (DIR), Baird DD (DIR). Environ Health Perspect. 2015 Nov 13. [Epub ahead of print] [Abstract] 2015 Goal 2
Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Sen A, Heredia N, Senut MC, Land S, Hollocher K, Lu X, Dereski MO, Ruden DM. Sci Rep. 2015 Sep 29;5:14466. [Abstract] 2015 Goal 2
Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Environ Health Perspect. 2015 Dec 18. [Abstract] 2015 Goal 2
Prenatal phthalate exposures and body mass index among 4 to 7 year old children: A pooled analysis.  Buckley JP, Engel SM, Braun JM, Whyatt RM, Daniels JL, Mendez MA, Richardson DB, Xu Y, Calafat AM, Wolff MS, Lanphear BP, Herring AH, Rundle AG. Epidemiology. 2016 Jan 6. [Epub ahead of print] [Abstract] 2016 Goal 2
Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 1. Sexually dimorphic effects on social and anxiety-like behaviors. Bell MR, Thompson LM, Rodriguez K, Gore AC. Horm Behav. 2016 Feb;78:168-77. [Abstract] 2016 Goal 2
Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 2. Sex-specific neuromolecular effects in the brain. Bell MR, Hart BG, Gore AC. Mol Cell Endocrinol. 2016 Jan 15;420:125-37. [Abstract] 2016 Goal 2
Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults. Markunas CA (DIR), AJ Wilcox (DIR), Z Xu (DIR), BR Joubert (DIR), S Harlid (DIR), V Panduri (DIR), SE Haberg, W Nystad, SJ London (DIR), DP Sandler (DIR), RT Lie, PA Wade (DIR) and JA Taylor (DIR). PLoS ONE (2016) v. 11 (7): pp. e0156361 [Abstract] 2016 Goal 2
Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children. Rowe C, Gunier R, Bradman A, Harley KG, Kogut K, Parra K, Eskenazi B. Environ Res. 2016 Jun 6;150:128-137.   [Abstract] 2016 Goal 2
Residential proximity to traffic and female pubertal development.  McGuinn LA, Voss RW, Laurent CA, Greenspan LC, Kushi LH, Windham GC. Environ Int. 2016 Jul 1. pii: S0160-4120(16)30251-3. [Abstract] 2016 Goal 2
Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks. Glicksberg BS, Li L, Badgeley MA, Shameer K, Kosoy R, Beckmann ND, Pho N, Hakenberg J, Ma M, Ayers KL, Hoffman GE, Dan Li S, Schadt EE, Patel CJ, Chen R, Dudley JT. Bioinformatics. 2016 Jun 15;32(12):i101-i110. [Abstract] 2016 Goal 2
Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum. Jusko TA, Oktapodas M, Palkovičová Murinová L, Babinská K, Babjaková J, Verner MA, DeWitt JC, Thevenet-Morrison K, Čonka K, Drobná B, Chovancová J, Thurston SW, Lawrence BP, Dozier AM, Järvinen KM, Patayová H, Trnovec T, Legler J, Hertz-Picciotto I, Lamoree MH. Environ Sci Technol. 2016 Jul 5;50(13):7152-62. [Abstract] 2016 Goal 2
A family-based, genome-wide association study of young-onset breast cancer: inherited variants and maternally mediated effects. O'Brien KM (DIR), Shi M (DIR), Sandler DP (DIR), Taylor JA (DIR), Zaykin DV (DIR), Keller J, Wise AS (DIR), Weinberg CR (DIR). Eur J Hum Genet. 2016 Feb 17. [Abstract] 2016 Goal 2
Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women. Parks CG (DIR), AA D'Aloisio (DIR) and DP Sandler (DIR). Front. Immunol. (2016) v. 7 pp. 103. [Abstract] 2016 Goal 2
Association between prenatal exposure to ambient diesel particulate matter and perchloroethylene with children's 3rd grade standardized test scores. Stingone JA, McVeigh KH, Claudio L. Environ Res. 2016 Apr 5;148:144-153. [Abstract] 2016 Goal 2
Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children. Huen K, Calafat AM, Bradman A, Yousefi P, Eskenazi B, Holland N. Environ Res. 2016 Mar 25;148:55-62. [Abstract] 2016 Goal 2
Parental whole life cycle exposure to dietary methylmercury in zebrafish (Danio rerio) affects the behavior of offspring. Mora-Zamorano FX, Klingler R, Murphy C, Basu N, Head JH, Carvan Iii MJ. Environ Sci Technol. 2016 Mar 29. [Epub ahead of print] [Abstract] 2016 Goal 2
Exposure to Greenness and Mortality in a Nationwide Prospective Cohort Study of Women. James P, Hart JE, Banay RF, Laden F. Environ Health Perspect. 2016 Apr 14. [Epub ahead of print] [Abstract] 2016 Goal 2
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. Williams CJ (DIR), A Chu, WN Jefferson (DIR), D Casero, D Sudhakar, N Khurana, CP Hogue, C Aryasomayajula, P Patel, P Sullivan, E Padilla-Banks (DIR), S Mohandessi, C Janzen and M Wadehra. J Pathol (2017). [Abstract] 2017 Goal 2
Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity. Cisse YM, Russart KL, Nelson RJ. Sci Rep. 2017 Mar 31;7:45497. [Abstract] 2017 Goal 2
Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure. Stanko JP (NTP), GE Kissling (DIR), VA Chappell (NTP) and SE Fenton (NTP). Toxicol. Pathol. (2016) v. 44 (7): pp. 1021-33. [Abstract] 2017 Goal 2
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Reid NM, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci D, Oleksiak MF, Crawford DL, Whitehead A.Science Dec 9 2016; 354(6317):1305-1308. [Abstract] 2017 Goal 2
Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes. Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. Cell Rep. 2016 Dec 13;17(11):3035-3048. [Abstract] 2016 Goal 2
Associations among personal care product use patterns and exogenous hormone use in the NIEHS Sister Study. Taylor KW (NTP), DD Baird (DIR), AH Herring, LS Engel, HB Nichols, DP Sandler (DIR) and MA Troester. J. Expo. Sci. Environ. Epidemiol. (2017). [Abstract] 2017 Goal 2
The Association of Arsenic Exposure and Metabolism with Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. Grau-Perez M, CC Kuo, M Spratlen, KA Thayer (NTP), MA Mendez, RF Hamman, D Dabelea, JL Adgate, WC Knowler, RA Bell, FW Miller (DIR), AD Liese, C Zhang, C Douillet, Z Drobna, EJ Mayer-Davis, M Styblo and A Navas-Acien. Diabetes Care (2016). [Abstract] 2017 Goal 2
Relationship between obesity and anti-Mullerian hormone in reproductive-aged African American women. Bernardi LA, Carnethon MR, de Chavez PJ, Ikhena DE, Neff LM, Baird DD (DIR), Marsh EE. Obesity (Silver Spring). 2017 Jan;25(1):229-235. [Abstract] 2017 Goal 2
Pre-conception and prenatal alcohol exposure from mothers and fathers drinking and head circumference: results from the Norwegian Mother-Child Study (MoBa). Zuccolo L, DeRoo LA, Wills AK, Davey Smith G, Suren P, Roth C, Stoltenberg C, Magnus P. Sci Rep. 2016 Dec 23;7:39535. [Abstract] 2017 Goal 2
The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort. Renzetti S, Just AC, Burris HH, Oken E, Amarasiriwardena C, Svensson K, Mercado-Garcia A, Cantoral A, Schnaas L, Baccarelli AA, Wright RO, Tellez-Rojo MM. 2017. Environ Res 2017 Jan; 152:226-232. [Abstract] 2017 Goal 2
Air pollution affects lung cancer survival. Eckel SP, Cockburn M, Shu YH, Deng H, Lurmann FW, Liu L, Gilliland FD. Thorax 2016 Oct; 71(10):891-898. [Abstract] 2016 Goal 2
Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California. Zota AR, Linderholm L, Park JS, Petreas M, Guo T, Privalsky ML, Zoeller RT, Woodruff TJ. Environ Sci Technol. 2013 Oct 15;47(20):11776-84. doi: 10.1021/es402204y. Epub 2013 Sep 25. [Abstract] 2014 Goal 3
Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Salo PM (DIR), SJ Arbes, Jr., R Jaramillo, A Calatroni, CH Weir, ML Sever, JA Hoppin (DIR), KM Rose, AH Liu, PJ Gergen, HE Mitchell and DC Zeldin (DIR). J. Allergy Clin. Immunol. (2014) [InPress] [Abstract] 2014 Goal 3
Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. PLoS One. 2013 May 29;8(5):e64128. doi: 10.1371/journal.pone.0064128. Print 2013. [Abstract] 2014 Goal 3
Prenatal exposure to air pollution, maternal psychological distress, and child behavior. Perera FP, Wang S, Rauh V, Zhou H, Stigter L, Camann D, Jedrychowski W, Mroz E, Majewska R. Pediatrics. 2013 Nov;132(5):e1284-94. doi: 10.1542/peds.2012-3844. Epub 2013 Oct 7. [Abstract] 2014 Goal 3
Prenatal Arsenic Exposure and the Epigenome: Identifying Sites of 5-methylcytosine Alterations that Predict Functional Changes in Gene Expression in Newborn Cord Blood and Subsequent Birth Outcomes. Rojas D, Rager JE, Smeester L, Bailey KA, Drobná Z, Rubio-Andrade M, Stýblo M, García-Vargas G, Fry RC. Toxicol Sci. 2015 Jan;143(1):97-106. [Abstract] 2015 Goal 3
Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB). Whitworth KW, RM Bornman, JI Archer, MO Kudumu, GS Travlos (NTP), RE Wilson (NTP) and MP Longnecker (DIR). Environ. Health Perspect (2014) [ePub]. [Abstract] 2014 Goal 3
Placing epidemiological results in the context of multiplicity and typical correlations of exposures. Patel CJ, Ioannidis JP. J Epidemiol Community Health. 2014 Jun 12. pii: jech-2014-204195. [Abstract] 2014 Goal 3
Pharmacokinetics of bisphenol A in humans following a single oral administration. Thayer KA (NTP), DR Doerge, D Hunt (DIR), SH Schurman (DIR), NC Twaddle, MI Churchwell, S Garantziotis (DIR), GE Kissling (DIR), MR Easterling, JR Bucher (NTP) and LS Birnbaum (OD). Environ Int (2015) v. 83 pp. 107-115 [Abstract] 2015 Goal 3
Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study. Lebov JF, LS Engel, D Richardson, SL Hogan, JA Hoppin and DP Sandler (DIR). Occup. Environ. Med. (2015) [ePub] [Abstract] 2015 Goal 3
Occupational Determinants of Cumulative Lead Exposure: Analysis of Bone Lead Among Men in the VA Normative Aging Study. Ji JS, Schwartz J, Sparrow D, Hu H, Weisskopf MG. J Occup Environ Med. 2014 Apr;56(4):435-40. [Abstract] 2014 Goal 3
Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? Stapleton PA, Minarchick VC, Yi J, Engels K, McBride CR, Nurkiewicz TR. Am J Obstet Gynecol. 2013 Sep;209(3):227.e1-11. doi: 10.1016/j.ajog.2013.04.036. Epub 2013 Apr 30. [Abstract] 2014 Goal 3
Increasing sample size in prospective birth cohorts: back-extrapolating prenatal levels of persistent organic pollutants in newly enrolled children. Verner MA, Gaspar FW, Chevrier J, Gunier RB, Sjödin A, Bradman A, Eskenazi B. Environ Sci Technol. 2015 Mar 17;49(6):3940-8. [Abstract] 2015 Goal 3
Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. House, JS (DIR), Li, H (DIR), DeGraff, LM (DIR), Flake, G (NTP), Zeldin, DC (DIR) and London, SJ (DIR). FASEB J. (2014) [ePub]. [Abstract] 2015 Goal 3
F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation. Harvey JB (DNTP), Hong HH (DNTP), Bhusari S, Ton TV (DNTP), Wang Y (DNTP), Foley JF (DNTP), Peddada SD (DIR), Hooth M (DNTP), DeVito M (DNTP), Nyska A, Pandiri AR (DNTP), Hoenerhoff MJ (DNTP). Veterinary pathology. 2015. Epub 2015/03/02 [Abstract] 2015 Goal 3
Elevated serum pesticide levels and risk for Alzheimer disease. Richardson JR, Roy A, Shalat SL, von Stein RT, Hossain MM, Buckley B, Gearing M, Levey AI, German DC. JAMA Neurol. 2014 Mar;71(3):284-90. doi: 10.1001/jamaneurol.2013.6030. [Abstract] 2014 Goal 3
Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity. French, JE (NTP), Gatti, DM, Morgan, DL (NTP), Kissling, GE (DIR), Shockley, KR (DIR), Knudsen, GA (OD), Shepard, KG, Price, HC, King, D (NTP), Witt, KL (NTP), Pedersen, LC (DIR), Munger, SC, Svenson, KL and Churchill, GA. Environ. Health Perspect. (2014)[ePub] [Abstract] 2015 Goal 3
Development of Phenotypic and Transcriptional Biomarkers to Evaluate Relative Activity of Potentially Estrogenic Chemicals in Ovariectomized Mice. Hewitt SC (DIR), W Winuthayanon (DIR), B Pockette (DIR), RT Kerns (DIR), JF Foley (NTP), N Flagler (NTP), E Ney (NTP), A Suksamrarn, P Piyachaturawat, PR Bushel (DIR) and KS Korach(DIR). Nat. Biotechnol. Environ. Health Perspect. (2015) v. 123 (4): pp. 344-352 [Abstract] 2015 Goal 3
Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells. Person RJ (DNTP), Olive Ngalame NN (DNTP), Makia NL (DIR), Bell MW (DNTP), Waalkes MP (DNTP), Tokar EJ (DNTP). Toxicology and applied pharmacology. 2015. Epub 2015/03/21 [Abstract] 2015 Goal 3
Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. Prins GS, Hu WY, Shi GB, Hu DP, Majumdar S, Li G, Huang K, Nelles JL, Ho SM, Walker CL, Kajdacsy-Balla A, van Breemen RB. Endocrinology. 2014 Mar;155(3):805-17. doi: 10.1210/en.2013-1955. Epub 2014 Jan 1. [Abstract] 2014 Goal 3
A novel system to generate WTC dust particles for inhalation exposures. Vaughan JM, Garrett BJ, Prophete C, Horton L, Sisco M, Soukup JM, Zelikoff JT, Ghio A, Peltier RE, Asgharian B, Chen LC, Cohen MD. Journal of Exposure Science and Environmental Epidemiology (2014) v. 24 (1): pp. 105-112. [Abstract] 2014 Goal 3
Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Environ Health Perspect. 2015 Dec 18. [Abstract] 2015 Goal 3
Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Sen A, Heredia N, Senut MC, Land S, Hollocher K, Lu X, Dereski MO, Ruden DM. Sci Rep. 2015 Sep 29;5:14466. [Abstract] 2015 Goal 3
Prenatal phthalate exposures and body mass index among 4 to 7 year old children: A pooled analysis.  Buckley JP, Engel SM, Braun JM, Whyatt RM, Daniels JL, Mendez MA, Richardson DB, Xu Y, Calafat AM, Wolff MS, Lanphear BP, Herring AH, Rundle AG. Epidemiology. 2016 Jan 6. [Epub ahead of print] [Abstract] 2016 Goal 3
Nail polish as a source of exposure to triphenyl phosphate.  Mendelsohn E, Hagopian A, Hoffman K, Butt CM, Lorenzo A, Congleton J, Webster TF, Stapleton HM. Environ Int. 2016 Jan;86:45-51. [Abstract] 2016 Goal 3
DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy. Reese SE (DIR), S Zhao (DIR), MC Wu, BR Joubert (DERT), CL Parr (DIR), SE Haberg, PM Ueland, RM Nilsen, O Midttun, SE Vollset, SD Peddada (DIR), W Nystad and SJ London (DIR). Environ Health Perspect (2016) [InPress] [Abstract] 2016 Goal 3
Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study. Bonner MR, LE Beane Freeman, JA Hoppin, S Koutros, DP Sandler (DIR), CF Lynch, CJ Hines, K Thomas, A Blair and MC Alavanja. Environ. Health Perspect. (2016) [Abstract] 2016 Goal 3
Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures. Parks CG (DIR), JA Hoppin, AJ DeRoos, KH Costenbader, MC Alavanja and DP Sandler (DIR). Environ Health Perspect (2016) [InPress] [Abstract] 2016 Goal 3
Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children. Rowe C, Gunier R, Bradman A, Harley KG, Kogut K, Parra K, Eskenazi B. Environ Res. 2016 Jun 6;150:128-137. [Abstract] 2016 Goal 3
Residential proximity to traffic and female pubertal development.  McGuinn LA, Voss RW, Laurent CA, Greenspan LC, Kushi LH, Windham GC. Environ Int. 2016 Jul 1. pii: S0160-4120(16)30251-3. [Abstract] 2016 Goal 3
Regions of variable DNA methylation in human placenta associated with newborn neurobehavior. Paquette AG, Houseman EA, Green BB, Lesseur C, Armstrong DA, Lester B, Marsit CJ. Epigenetics. 2016 Aug 2;11(8):603-13. [Abstract] 2016 Goal 3
Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants. Hu XC, Andrews DQ, Lindstrom AB, Bruton TA,  Schaider LA, Grandjean P, Lohmann R, Carignan CC, Blum A, Balan SA, Higgins CP, Sunderland EM. Environ. Sci. Technol. Lett., Article ASAP Publication Date (Web): August 9, 2016 [Abstract] 2016 Goal 3
Parental whole life cycle exposure to dietary methylmercury in zebrafish (Danio rerio) affects the behavior of offspring. Mora-Zamorano FX, Klingler R, Murphy C, Basu N, Head JH, Carvan Iii MJ. Environ Sci Technol. 2016 Mar 29. [Epub ahead of print] [Abstract] 2016 Goal 3
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Xiao S, JR Coppeta, HB Rogers, BC Isenberg, J Zhu, SA Olalekan, KE McKinnon, D Dokic, AS Rashedi, DJ Haisenleder, SS Malpani, CA Arnold-Murray, KW Chen, MY Jiang, L Bai, CT Nguyen, JY Zhang, MM Laronda, TJ Hope, KP Maniar, ME Pavone, MJ Avram, EC Sefton, S Getsios, JE Burdette, JJ Kim, JT Borenstein and TK Woodruff. Nature communications (2017) v. 8. [Abstract] 2017 Goal 3
Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Stem Cells. 2016 Dec 29. [Abstract] 2016 Goal 3
Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Ho SM, Rao RC, To S, Schoch E, Tarapore P. Endocr Relat Cancer. 2016 Dec 20. [Abstract] 2016 Goal 3
Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach. O' Lenick CR, Chang HH, Kramer MR, Winquist A, Mulholland JA, Friberg MD, Sarnat SE. Environ Health. 2017 Apr 5;16(1):36. [Abstract] 2017 Goal 3
Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes. Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. Cell Rep. 2016 Dec 13;17(11):3035-3048. [Abstract] 2016 Goal 3
The Association of Arsenic Exposure and Metabolism with Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. Grau-Perez M, CC Kuo, M Spratlen, KA Thayer (NTP), MA Mendez, RF Hamman, D Dabelea, JL Adgate, WC Knowler, RA Bell, FW Miller (DIR), AD Liese, C Zhang, C Douillet, Z Drobna, EJ Mayer-Davis, M Styblo and A Navas-Acien. Diabetes Care (2016). [Abstract] 2017 Goal 3
Pre-conception and prenatal alcohol exposure from mothers and fathers drinking and head circumference: results from the Norwegian Mother-Child Study (MoBa). Zuccolo L, DeRoo LA, Wills AK, Davey Smith G, Suren P, Roth C, Stoltenberg C, Magnus P. Sci Rep. 2016 Dec 23;7:39535. [Abstract] 2017 Goal 3
The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort. Renzetti S, Just AC, Burris HH, Oken E, Amarasiriwardena C, Svensson K, Mercado-Garcia A, Cantoral A, Schnaas L, Baccarelli AA, Wright RO, Tellez-Rojo MM. 2017. Environ Res 2017 Jan; 152:226-232. [Abstract] 2016 Goal 3
Air pollution affects lung cancer survival. Eckel SP, Cockburn M, Shu YH, Deng H, Lurmann FW, Liu L, Gilliland FD. Thorax 2016 Oct; 71(10):891-898. [Abstract] 2016 Goal 3
Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study. Chen A, Yolton K, Rauch SA, Webster GM, Hornung R, Sjödin A, Dietrich KN, Lanphear BP. Environ Health Perspect. 2014 Aug;122(8):856-62. [Abstract] 2014 Goal 4
Prenatal exposure to organophosphate pesticides and reciprocal social behavior in childhood. Furlong MA, Engel SM, Barr DB, Wolff MS. Environ Int. 2014 Sep;70:125-31. [Abstract] 2015 Goal 4
Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study. Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I. Environ Health Perspect. 2014 Jun 23. [Abstract] 2014 Goal 4
NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Chrysovergis K (DIR), X Wang (DIR), J Kosak (DIR), SH Lee, J Sik Kim (DIR), JF Foley (NTP), G Travlos (NTP), S Singh (DIR), S Joon Baek and TE Eling(DIR). Int J Obes (Lond) (2014) InPress. [Abstract] 2014 Goal 4
Indoor determinants of dustborne allergens in Mexican homes. Hernández-Cadena L, Zeldin DC (DIR), Barraza-Villarreal A, Sever ML (DIR), Sly PD, London SJ (DIR), Escamilla-Nuñez MC, Romieu I. Allergy Asthma Proc. 2015 Mar-Apr;36(2):130-7. [Abstract] 2015 Goal 4
Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism. Lu, K, Mahbub, R, Cable, PH, Ru, HY, Parry, NMA, Bodnar, WM, Wishnok, JS, Styblo, M, Swenberg, JA, Fox, JG and Tannenbaum, SR. Chem. Res. Toxicol. (2014) v. 27 (2): pp. 172-174. [Abstract] 2014 Goal 4
Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA.Biostatistics. 2014 Dec 22. pii: kxu058. [Epub ahead of print] [Abstract] 2015 Goal 4
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Goodson WH et al., June 2015. Carcinogenesis 36(Suppl 1): S254-296. [Abstract] 2015 Goal 4
Anti-müllerian hormone and lifestyle, reproductive, and environmental factors among women in rural South Africa. Whitworth KW, Baird DD (DIR), Steiner AZ, Bornman RM, Travlos GS (DIR), Wilson RE (DIR), Longnecker MP (DIR). Epidemiology. 2015 May;26(3):429-35. [Abstract] 2015 Goal 4
Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Fang M, Webster TF, Stapleton HM.  Environ. Sci. Technol., Publication Date (Web): July 14, 2015 [Abstract] 2015 Goal 4
Endotoxin Exposure: Predictors and Prevalence of Associated Asthma Outcomes in the United States. Thorne PS, Mendy A, Metwali N, Salo P, Co C, Jaramillo R, Rose KM, Zeldin DC. J Respir Crit Care Med. 2015 Dec 1;192(11):1287-97. [Abstract] 2015 Goal 4
Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes. Allen JG, Flanigan SS, LeBlanc M, Vallarino J, MacNaughton P, Stewart JH, Christiani DC. Environ Health Perspect. 2015 Dec 8. [Epub ahead of print] [Abstract] 2015 Goal 4
Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Sen A, Heredia N, Senut MC, Land S, Hollocher K, Lu X, Dereski MO, Ruden DM. Sci Rep. 2015 Sep 29;5:14466. [Abstract] 2015 Goal 4
Bacterial microbiome of breast milk and child saliva from low-income Mexican-American women and children. Davé V, Street K, Francis S, Bradman A, Riley L, Eskenazi B, Holland N. Pediatr Res. 2016 Jan 12. [Abstract] 2016 Goal 4
Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats. Hicks KD, Sullivan AW, Cao J, Sluzas E, Rebuli M, Patisaul HB. Horm Behav. 2016 Jun 30;84:121-126. [Abstract] 2016 Goal 4
Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003-2010. Zota AR, Phillips CA, Mitro SD. Environ Health Perspect. 2016 Apr 13. [Epub ahead of print] [Abstract] 2016 Goal 4
DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Gao L, Mutlu E (DNTP), Collins LB, Walker NJ (DNTP), Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. Chem Res Toxicol. 2017 Mar 20;30(3):794-803. [Abstract] 2017 Goal 4
Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes. Ferrucio B, M Tiago, RD Fannin (DIR), L Liu (DIR), K Gerrish (DIR), SS Maria-Engler, RS Paules (NTP) and SB de Moraes Barros. Toxicol In Vitro (2016). [Abstract] 2016 Goal 4
Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes. Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. Cell Rep. 2016 Dec 13;17(11):3035-3048. [Abstract] 2016 Goal 4
Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach. O' Lenick CR, Chang HH, Kramer MR, Winquist A, Mulholland JA, Friberg MD, Sarnat SE. Environ Health. 2017 Apr 5;16(1):36. [Abstract] 2017 Goal 4
B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation: A Pilot Human Intervention Trial. Zhong J, Trevisi L, Urch B, Lin X, Speck M, Coull BA, Liss G, Thompson A, Wu S, Wilson A, Koutrakis P, Silverman F, Gold DR, Baccarelli AA. Sci Rep. 2017 Apr 3;7:45322. [Abstract] 2017 Goal 4
Tobacco use and cancer risk in the Agricultural Health Study. Andreotti G, Freedman ND, Silverman DT, Lerro CC, Koutros S, Hartge P, Alavanja MC, Sandler DP (DIR), Beane Freeman L. Cancer Epidemiol Biomarkers Prev. 2016 Dec 29. [Abstract] 2016 Goal 4
Air pollution affects lung cancer survival. Eckel SP, Cockburn M, Shu YH, Deng H, Lurmann FW, Liu L, Gilliland FD. Thorax 2016 Oct; 71(10):891-898. [Abstract] 2016 Goal 4
The commonly used antimicrobial additive triclosan is a liver tumor promoter. Yueh M-F, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, and Tukey RH.  2014. Proc Natl Acad Sci U S A 111(48): 17200-17205. [Abstract] 2015 Goal 5
Quantitative assessment of inhalation exposure and deposited dose of aerosol from nanotechnology-based consumer sprays. Nazarenko Y, Lioy PJ, Mainelis G. Environ Sci Nano. 2014 Apr;1(2):161-171. [Abstract] 2015 Goal 5
Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. PLoS One. 2013 May 29;8(5):e64128. doi: 10.1371/journal.pone.0064128. Print 2013. [Abstract] 2014 Goal 5
Prenatal exposure to air pollution, maternal psychological distress, and child behavior. Perera FP, Wang S, Rauh V, Zhou H, Stigter L, Camann D, Jedrychowski W, Mroz E, Majewska R. Pediatrics. 2013 Nov;132(5):e1284-94. doi: 10.1542/peds.2012-3844. Epub 2013 Oct 7. [Abstract] 2014 Goal 5
Mental health service use by cleanup workers in the aftermath of the Deepwater Horizon oil spill. Lowe SR, Kwok RK (DIR), Payne J, Engel LS (DIR), Galea S, Sandler DP (DIR). Soc Sci Med. 2015 Apr;130:125-34. [Abstract] 2015 Goal 5
Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. Waalkes MP (NTP), Qu W (NTP), Tokar EJ (NTP), Kissling GE (DIR), Dixon D (NTP). Archives of toxicology. 2014. [Epub 2014/07/10] [Abstract] 2014 Goal 5
Impact of Natural Gas Extraction on PAH Levels in Ambient Air. Paulik LB, Donald CE, Smith BW, Tidwell LG, Hobbie KA, Kincl L, Haynes EN, Anderson KA.  Environ Sci Technol. 2015 Apr 21;49(8):5203-10. [Abstract] 2014 Goal 5
Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Carignan CC, Cottingham KL, Jackson BP, Farzan SF, Gandolfi AJ, Punshon T, Folt CL, Karagas MR. Environ Health Perspect. 2015 May;123(5):500-6. [Abstract] 2015 Goal 5
Co-benefits of mitigating global greenhouse gas emissions for future air quality and human health West, JJ, Smith, SJ, Silva, RA, Naik, V, Zhang, YQ, Adelman, Z, Fry, MM, Anenberg, S, Horowitz, LW and Lamarque, JF [Journal Article] Nat. Clim. Chang. (2013) v. 3 (10): pp. 885-889 [Abstract] 2014 Goal 5
Blood lead concentrations and children's behavioral and emotional problems: A Cohort Study. Liu J, Liu X, Wang W, McCauley L, Pinto-Martin J, Wang Y, Li L, Yan C, Rogan WJ (DIR). JAMA Pediatr. 2014 Aug 1;168(8):737-45. [Abstract] 2014 Goal 5
A novel system to generate WTC dust particles for inhalation exposures. Vaughan JM, Garrett BJ, Prophete C, Horton L, Sisco M, Soukup JM, Zelikoff JT, Ghio A, Peltier RE, Asgharian B, Chen LC, Cohen MD. Journal of Exposure Science and Environmental Epidemiology (2014) v. 24 (1): pp. 105-112. [Abstract] 2014 Goal 5
Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Gerona RR, Pan J, Zota AR, Schwartz JM, Friesen M, Taylor JA, Hunt PA, Woodruff TJ. Environ Health. 2016 Apr 12;15(1):50. [Abstract] 2016 Goal 5
Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes. Ferrucio B, M Tiago, RD Fannin (DIR), L Liu (DIR), K Gerrish (DIR), SS Maria-Engler, RS Paules (NTP) and SB de Moraes Barros. Toxicol In Vitro (2016). [Abstract] 2016 Goal 5
Evaluation of tumorigenic potential of CeO2 and Fe2O3 engineered nanoparticles by a human cell in vitro screening model. Stueckle TA, DC Davidson, R Derk, TG Kornberg, D Schwegler-Berry, SV Pirela, G Deloid, P Demokritou, S Luanpitpong, Y Rojanasakul and L Wang. NanoImpact (2017) v. 6 pp. 39-54. [Abstract] 2017 Goal 5
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Moreno-Estrada A, Gignoux CR, Fernández-López JC, Zakharia F, Sikora M, Contreras AV, Acuña-Alonzo V, Sandoval K, Eng C, Romero-Hidalgo S, Ortiz-Tello P, Robles V, Kenny EE, Nuño-Arana I, Barquera-Lozano R, Macín-Pérez G, Granados-Arriola J, Huntsman S, Galanter JM, Via M, Ford JG, Chapela R, Rodriguez-Cintron W, Rodríguez-Santana JR, Romieu I, Sienra-Monge JJ, del Rio Navarro B, London SJ (DIR), Ruiz-Linares A, Garcia-Herrera R, Estrada K, Hidalgo-Miranda A, Jimenez-Sanchez G, Carnevale A, Soberón X, Canizales-Quinteros S, Rangel-Villalobos H, Silva-Zolezzi I, Burchard EG, Bustamante CD. Science. 2014 Jun 13;344(6189):1280-5. [Abstract] 2014 Goal 6
Secondhand Tobacco Smoke Exposure and Neuromotor Function in Rural Children. Yeramaneni S, Dietrich KN, Yolton K, Parsons PJ, Aldous KM, Haynes EN. J Pediatr. 2015 Apr 13. [Epub ahead of print] [Abstract] 2015 Goal 6
Risk-benefit profiles of women using tamoxifen for chemoprevention. Nichols HB, LA DeRoo, DR Scharf and DP Sandler (DIR). Journal of the National Cancer Institute (2015) v. 107 (1): pp. 1-8 [Abstract] 2015 Goal 6
Prenatal exposure to organophosphate pesticides and reciprocal social behavior in childhood. Furlong MA, Engel SM, Barr DB, Wolff MS. Environ Int. 2014 Sep;70:125-31. [Abstract] 2014 Goal 6
Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB). Whitworth KW, RM Bornman, JI Archer, MO Kudumu, GS Travlos (NTP), RE Wilson (NTP) and MP Longnecker (DIR). Environ. Health Perspect (2014) [ePub]. [Abstract] 2014 Goal 6
Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study. Lebov JF, LS Engel, D Richardson, SL Hogan, JA Hoppin and DP Sandler (DIR). Occup. Environ. Med. (2015) [ePub] [Abstract] 2015 Goal 6
Overweight and Obesity Prevalence Among School-Aged Nunavik Inuit Children According to Three Body Mass Index Classification Systems. Medehouenou TC, Ayotte P, St-Jean A, Meziou S, Roy C, Muckle G, Lucas M. J Adolesc Health. 2015 Jul;57(1):31-6. [Abstract] 2015 Goal 6
Occupational Determinants of Cumulative Lead Exposure: Analysis of Bone Lead Among Men in the VA Normative Aging Study. Ji JS, Schwartz J, Sparrow D, Hu H, Weisskopf MG. J Occup Environ Med. 2014 Apr;56(4):435-40. [Abstract] 2014 Goal 6
Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study. Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I. Environ Health Perspect. 2014 Jun 23. [Abstract] 2014 Goal 6
Loss of Hypoxia-Inducible Factor 2 Alpha in the Lung Alveolar Epithelium of Mice Leads to Enhanced Eosinophilic Inflammation in Cobalt-Induced Lung Injury. Proper, SP, Saini, Y, Greenwood, KK, Bramble, LA, Downing, NJ, Harkema, JR and LaPres, JJ. Toxicol. Sci. (2014) v. 137 (2): pp. 447-457. [Abstract] 2014 Goal 6
Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C. Environ Health Perspect. 2015 Jun 26. [Epub ahead of print] [Abstract] 2015 Goal 6
Interplay between polymorphisms and methylation in the H19/IGF2 gene region may contribute to obesity in Mexican-American children M. A. Hernández-Valero, J. Rother, I. Gorlov, M. Frazier and O. Gorlova [Journal Article] Journal of Developmental Origins of Health and Disease (2013) v. 4 (6): pp. 499-506 [Abstract] 2014 Goal 6
Indoor Particulate Matter Concentration, Water Boiling Time, and Fuel Use of Selected Alternative Cookstoves in a Home-Like Setting in Rural Nepal. Ojo KD, Soneja SI, Scrafford CG, Khatry SK, LeClerq SC, Checkley W, Katz J, Breysse PN, Tielsch JM. Int J Environ Res Public Health. 2015 Jul 7;12(7):7558-81. [Abstract] 2015 Goal 6
Household reporting of childhood respiratory health and air pollution in rural Alaska Native communities. Ware DN, Lewis J, Hopkins S, Boyer B, Montrose L, Noonan CW, Semmens EO, Ward TJ. Int J Circumpolar Health. 2014 May 9;73:1-10. [Abstract] 2014 Goal 6
Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer. Xu Z and JA Taylor. Carcinogenesis (2014) v. 35 (2): pp. 356-364. [Abstract] 2014 Goal 6
Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products. Myers SL (DIR), CZ Yang, GD Bittner, KL Witt (NTP), RR Tice (NTP) and DD Baird (DIR). J Expo Sci Environ Epidemiol (2014). [Epub] [Abstract] 2014 Goal 6
Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer. Weinberg, CR, Shi, M, Deroo, LA, Taylor, JA, Sandler, DP and Umbach, DM. PLoS Genet (2014) v. 10 (3): pp. e1004174. [Abstract] 2014 Goal 6
Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women. Jukic, AM (DIR), Steiner, AZ and Baird, DD (DIR). Menopause (2014) Aug 4. [ePub]. [Abstract] 2014 Goal 6
Ambient Air Pollution Exposure and Incident Adult Asthma in a Nationwide Cohort of U.S. Women. Young, MT, Sandler, DP (DIR), DeRoo, LA (DIR), Vedal, S, Kaufman, JD and London, SJ (DIR). Am. J. Respir. Crit. Care Med. (2014) [Abstract] 2015 Goal 6
Admixture Mapping of Prostate Cancer in African Americans Participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP) Bensen, JT, Xu, ZL, McKeigue, PM, Smith, GJ, Fontham, ETH, Mohler, JL and Taylor, JA [Journal Article] Prostate (2014) v. 74 (1): pp. 1-9 [Abstract] 2014 Goal 6
A simulation model of building intervention impacts on indoor environmental quality, pediatric asthma, and costs. Fabian MP, Adamkiewicz G, Stout NK, Sandel M, Levy JI. J Allergy Clin Immunol. 2014 Jan;133(1):77-84. doi: 10.1016/j.jaci.2013.06.003. Epub 2013 Jul 31. [Abstract] 2014 Goal 6
Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Environ Health Perspect. 2015 Dec 18. [Abstract] 2015 Goal 6
Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach. O' Lenick CR, Chang HH, Kramer MR, Winquist A, Mulholland JA, Friberg MD, Sarnat SE. Environ Health. 2017 Apr 5;16(1):36. [Abstract] 2017 Goal 6
Relationship between obesity and anti-Mullerian hormone in reproductive-aged African American women. Bernardi LA, Carnethon MR, de Chavez PJ, Ikhena DE, Neff LM, Baird DD (DIR), Marsh EE. Obesity (Silver Spring). 2017 Jan;25(1):229-235. [Abstract] 2017 Goal 6
The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort. Renzetti S, Just AC, Burris HH, Oken E, Amarasiriwardena C, Svensson K, Mercado-Garcia A, Cantoral A, Schnaas L, Baccarelli AA, Wright RO, Tellez-Rojo MM. 2017. Environ Res 2017 Jan; 152:226-232. [Abstract] 2017 Goal 6
The Association of Arsenic Exposure and Metabolism with Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. Grau-Perez M, CC Kuo, M Spratlen, KA Thayer (NTP), MA Mendez, RF Hamman, D Dabelea, JL Adgate, WC Knowler, RA Bell, FW Miller (DIR), AD Liese, C Zhang, C Douillet, Z Drobna, EJ Mayer-Davis, M Styblo and A Navas-Acien. Diabetes Care (2016). [Abstract] 2016 Goal 6
The National Toxicology Program Web-based Nonneoplastic Lesion Atlas: A Global Toxicology and Pathology Resource. Cesta, MF (NTP), Malarkey, DE (NTP), Herbert, RA (NTP), Brix, A, Hamlin, MH, 2nd, Singletary, E, Sills, RC (NTP), Bucher, JR (NTP) and Birnbaum, LS (DIR). Toxicol Pathol. 2014;42(2):458-60. doi: 10.1177/0192623313517304. [Abstract] 2014 Goal 7
Systematic Review and Evidence Integration for Literature-Based Environmental Health Science Assessments. Rooney AA (NTP), Boyles AL (NTP), Wolfe MS (NTP), Bucher JR (NTP), and Thayer KA (NTP). Environmental health perspectives. 2014. [Epub 2014/04/24] [Abstract] 2014 Goal 7
Dissecting neural differentiation regulatory networks through epigenetic footprinting. Ziller MJ, Edri R, Yaffe Y, Donaghey J, Pop R, Mallard W, Issner R, Gifford CA, Goren A, Xing J, Gu H, Cacchiarelli D, Tsankov AM, Epstein C, Rinn JL, Mikkelsen TS, Kohlbacher O, Gnirke A, Bernstein BE, Elkabetz Y, Meissner A. Nature. 2014 Dec 24. doi: 10.1038/nature13990. [Abstract] 2015 Goal 7
Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA.Biostatistics. 2014 Dec 22. pii: kxu058. [Epub ahead of print] [Abstract] 2015 Goal 7
A data analysis pipeline accounting for artifacts in tox21 quantitative high-throughput screening assays. Hsieh, JH (DNTP), Sedykh, A, Huang, R, Xia, M, Tice, RR (DNTP). J Biomol Screen. 2015. 2015/04/24 [Abstract] 2015 Goal 7
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Vandenberg LN, M Agerstrand, A Beronius, C Beausoleil, A Bergman, LA Bero, CG Bornehag, CS Boyer, GS Cooper, I Cotgreave, D Gee, P Grandjean, KZ Guyton, U Hass, JJ Heindel (DERT), S Jobling, KA Kidd, A Kortenkamp, MR Macleod, OV Martin, U Norinder, M Scheringer, KA Thayer (NTP), J Toppari, P Whaley, TJ Woodruff and C Ruden. Environ. Health (2016) v. 15 (1): pp. 74 [Abstract] 2016 Goal 7
Advancing toxicology research using in vivo high throughput toxicology with small fish models. Planchart, A, Mattingly, CJ, Allen, D, Ceger, P, Casey, W (DNTP), Hinton, D, Kanungo, J, Kullman, SW, Tal, T, Bondesson, M, Burgess, SM, Sullivan, C, Kim, C, Behl, M (DNTP), Padilla, S, Reif, DM, Tanguay, RL, Hamm, J. ALTEX. 2016. [Abstract] 2016 Goal 7
Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Smith, MT, Guyton, KZ, Gibbons, CF, Fritz, JM, Portier, CJ, Rusyn, I, DeMarini, DM, Caldwell, JC, Kavlock, RJ, Lambert, PF, Hecht, SS, Bucher, JR (DNTP), Stewart, BW, Baan, RA, Cogliano, VJ, Straif, K. Environmental Health Perspectives. 2016. 124(6): 713-721 [Abstract] 2016 Goal 7
Integrated decision strategies for skin sensitization hazard. Strickland J, Zang Q, Kleinstreuer N (DNTP), Paris M, Lehmann DM, Choksi N, Matheson J, Jacobs A, Lowit A, Allen D, Casey W (DNTP). J Appl Toxicol 36(9):1150-1162. [Abstract] 2016 Goal 7
Development and Validation of a Computational Model for Androgen Receptor Activity. Kleinstreuer NC (DNTP), Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM (DNTP), Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R. Chem Res Toxicol. 2016 Dec 9. [Abstract] 2016 Goal 7
Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB). Whitworth KW, RM Bornman, JI Archer, MO Kudumu, GS Travlos (NTP), RE Wilson (NTP) and MP Longnecker (DIR). Environ. Health Perspect (2014) [ePub]. [Abstract] 2014 Goal 8
Counseling patients on preventing prenatal environmental exposures--a mixed-methods study of obstetricians. Stotland NE, Sutton P, Trowbridge J, Atchley DS, Conry J, Trasande L, Gerbert B, Charlesworth A, Woodruff TJ. PLoS One. 2014 Jun 25;9(6):e98771. [Abstract] 2014 Goal 8
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. J Clin Invest. 2014 Jul;124(7):2935-46. [Abstract] 2015 Goal 9
Vulnerability of welders to manganese exposure--a neuroimaging study. Long Z, Jiang YM, Li XR, Fadel W, Xu J, Yeh CL, Long LL, Luo HL, Harezlak J, Murdoch JB, Zheng W, Dydak U. Neurotoxicology. 2014 Dec;45:285-92. [Abstract] 2015 Goal 9
Uterine microvascular sensitivity to nanomaterial inhalation: An in vivo assessment. Stapleton PA, McBride CR, Yi J, Nurkiewicz TR. Toxicol Appl Pharmacol. 2015 Sep 14. [Abstract] 2015 Goal 9
Using High-Resolution Satellite Aerosol Optical Depth To Estimate Daily PM2.5 Geographical Distribution in Mexico City. Just AC, Wright RO, Schwartz J, Coull BA, Baccarelli AA, Tellez-Rojo MM, Moody E, Wang Y, Lyapustin A, Kloog I. Environ Sci Technol. 2015 Jul 21; 49(14):8576-84. [Abstract] 2015 Goal 9
Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Padula AM, Mortimer KM, Tager IB, Hammond SK, Lurmann FW, Yang W, Stevenson DK, Shaw GM. Ann Epidemiol. 2014 Dec; 24(12):888-95e4. [Abstract] 2014 Goal 9
The Impact of Surface Ligands and Synthesis Method on the Toxicity of Glutathione-Coated Gold Nanoparticles. Harper B, Sinche F, Wu RH, Gowrishankar M, Marquart G, Mackiewicz M, Harper SL. Nanomaterials (Basel). 2014 Jun 1;4(2):355-371. [Abstract] 2014 Goal 9
The Genetic Architecture of Arsenic Metabolism Efficiency: A SNP-Based Heritability Study of Bangladeshi Adults. Gao J, Tong L, Argos M, Scannell Bryan M, Ahmed A, Rakibuz-Zaman M, Kibriya MG, Jasmine F, Slavkovich V, Graziano JH, Ahsan H, Pierce BL. Environ Health Perspect. 2015 Mar 13. [Abstract] 2015 Goal 9
Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR. Toxicol Appl Pharmacol. 2015 Sep 1; 287(2):93-7. [Abstract] 2015 Goal 9
Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52. Gaines WA, Godin SK, Kabbinavar FF, Rao T, VanDemark AP, Sung P, Bernstein KA. Nat Commun. 2015 Jul 28;6:7834. [Abstract] 2015 Goal 9
Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Rojas D, Rager JE, Smeester L, Bailey KA, Drobná Z, Rubio-Andrade M, Stýblo M, García-Vargas G, Fry RC. Toxicol Sci. 2015 Jan;143(1):97-106. [Abstract] 2015 Goal 9
POLG2 Disease Variants: Analyses Reveal a Dominant Negative Heterodimer, Altered Mitochondrial Localization, and Impaired Respiratory Capacity. Young MJ (DIR), MM Humble (DIR), KL DeBalsi (DIR), KY Sun (DIR) and WC Copeland (DIR). Hum. Mol. Genet. (2015) [InPress] [Abstract] 2015 Goal 9
PCR based determination of mitochondrial DNA copy number in multiple species. Rooney, JP, Ryde, IT, Sanders, LH, Howlett, EH, Colton, MD, Germ, KE, Mayer, GD, Greenamyre, JT and Meyer, JN. Methods Mol. Biol. (2015) v. 1241 pp. 23-38 [Abstract] 2015 Goal 9
Oncogenic KRAS confers chemoresistance by upregulating NRF2. Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Cancer Res. 2014 Dec 15;74(24):7430-41. [Abstract] 2015 Goal 9
Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. Larson-Casey JL, Murthy S, Ryan AJ, Carter AB. J Biol Chem. 2014 Dec 26;289(52):36204-19. [Abstract] 2015 Goal 9
Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes. Luz AL, Rooney JP, Kubik LL, Gonzalez CP, Song DH, Meyer JN. PLoS One. 2015 Jun 24;10(6):e0130940. [Abstract] 2015 Goal 9
MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin. Pellegrini KL, Han T, Bijol V, Saikumar J, Craciun FL, Chen WW, Fuscoe JC, Vaidya VS. Toxicol Sci. 2014 Oct;141(2):484-92. [Abstract] 2014 Goal 9
Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Wilker EH, Preis SR, Beiser AS, Wolf PA, Au R, Kloog I, Li W, Schwartz J, Koutrakis P, DeCarli C, Seshadri S, Mittleman MA. Stroke. 2015 May; 46(5):1161-6. [Abstract] 2014 Goal 9
Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Hajat A, Allison M, Diez-Roux AV, Jenny NS, Jorgensen NW, Szpiro AA, Vedal S, Kaufman JD. Epidemiology. 2015 May; 26(3):310-20. [Abstract] 2015 Goal 9
In Vitro Screening of Environmental Chemicals Identifies Zearalenone as a Novel Substrate of the Placental BCRP/ABCG2 Transporter. Xiao J, Wang Q, Bircsak KM, Wen X, Aleksunes LM. Toxicol Res (Camb). 2015 May 1;4(3):695-706. [Abstract] 2015 Goal 9
FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. Faulkner RL, Wishard TJ, Thompson CK, Liu HH, Cline HT. Eneuro. 2015 Jan-Feb: 2(1):e0055. [Abstract] 2015 Goal 9
Ferroportin deficiency impairs manganese metabolism in flatiron mice. Seo YA, Wessling-Resnick M. FASEB J. 2015 Jul; 29(7):2726-33. [Abstract] 2015 Goal 9
Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes. Posnack NG, Idrees R, Ding H, Jaimes R 3rd, Stybayeva G, Karabekian Z, Laflamme MA, Sarvazyan N. PLoS One. 2015 Mar 23: 10(3):e0121927. [Abstract] 2015 Goal 9
Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. Proc Natl Acad Sci USA. 2015 Jul 21; 112(29):9082-7. [Abstract] 2015 Goal 9
Development of exposome correlation globes to map out environment-wide associations.Patel CJ, Manrai AK. Pac Symp Biocomput. 2015:231-42. [Abstract] 2015 Goal 9
Construction and characterization of a sox9b transgenic reporter line. Plavicki JS, Baker TR, Burns FR, Xiong KM, Gooding AJ, Hofsteen P, Peterson RE, Heideman W. Int J Dev Biol. 2014; 58(9):693-9. [Abstract] 2014 Goal 9
Bisphenol a exposure disrupts metabolic health across multiple generations in the mouse. Susiarjo M, Xin F, Bansal A, Stefaniak M, Li C, Simmons RA, Bartolomei MS. Endocrinology. 2015 June; 156(6):2049-58. [Abstract] 2015 Goal 9
Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Fang M, Webster TF, Stapleton HM.  Environ. Sci. Technol., Publication Date (Web): July 14, 2015 [Abstract] 2015 Goal 9
A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB. PLoS Genet. 2014 Nov 6; 10(11):e1004753. [Abstract] 2014 Goal 9
A chemical and kinetic perspective on base excision repair of DNA. Schermerhorn KM, Delaney S. Acc Chem Res. 2014 Apr 15;47(4):1238-46. [Abstract] 2014 Goal 9
Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Caglayan M (DIR), JK Horton (DIR), DP Dai (DIR), DF Stefanick (DIR) and SH Wilson (DIR). Nature communications (2017) v. 8:14045. [Abstract] 2017 Goal 9
Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity. Cisse YM, Russart KL, Nelson RJ. Sci Rep. 2017 Mar 31;7:45497. [Abstract] 2017 Goal 9
B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation: A Pilot Human Intervention Trial. Zhong J, Trevisi L, Urch B, Lin X, Speck M, Coull BA, Liss G, Thompson A, Wu S, Wilson A, Koutrakis P, Silverman F, Gold DR, Baccarelli AA. Sci Rep. 2017 Apr 3;7:45322. [Abstract] 2017 Goal 9