| API | Application Program Interface |
| ATO | Authorization to Operate |
| BIA | Business Impact Analysis |
| CC | Clinical Center |
| CIO | Chief Information Officer |
| CISO | Chief Information Security Officer |
| CLC | Cyberinfrastructure Leadership Committee |
| CMS | Content Management System |
| COOP | Continuity of Operations Planning |
| CRB | Clinical Research Branch |
| CRU | Clinical Research Unit |
| DAS | Distributed Antenna System |
| DCIM | Data Center Infrastructure Management |
| DCOI | Data Center Optimization Initiative |
| DKM | Data and Knowledge Management |
| DMZ | Demilitarized Zone |
| Drupal | Web Content Management |
| DSL | Digital Subscriber Line |
| EHP | Environmental Health Perpsectives |
| EHS | Environmental Health Sciences |
| ELN | Electronic Lab Notebooks |
| EPA | Environmental Protection Agency |
| FAIR+ | Findable, Accessible, Interoperable, Reusable, and Computable |
| FITARA | Federal Information Acquisition Reform Act |
FOIA
| Freedom of Information Act |
| GSS | General Support System |
| HHS | Health and Human Services |
| HPC | High-Performance Computing |
| I&IT | Informatics and Information Technology |
| IPS | Intrusion Prevention System |
| IPv6 | Internet Protocol Version 6 |
| ISSO | Information Systems Security Officer |
| ITARG | Information Technology Architecture Review Group |
| ITT | Information Technology Team |
| LIMS | Laboratory Information Management Systems |
| NAC | Network Access Control |
| NIST | National Institute of Standards and Technology |
| NTP | National Toxicology Program |
| OMB | Office of Management and Budget |
| OOB | Out-of-Band Network |
| ORF | Office of Research Facilities |
| PaaS | Platform as a Service |
| PII | Personally Identifiable Information |
| PMO | Project Management Office |
| PUE | Power Use Effectiveness |
| QoS | Quality of Service |
| SaaS | Software as a Service |
| SOP | Standard Operating Procedure |
| VoIP | Voice Over Internet Protocol |
