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SOT 56th Annual Meeting and ToxExpo

Baltimore, MD • March 12-16, 2017

SOT 2017 logo Baltimore

NIEHS, NTP, and EHP Exhibit
ToxExpo Booth 2258/2260/2159/2161

Convention Center Exhibit Hall - Level 100

Additional Info:

ToxExpo Hours:

Monday, March 13 9:15 a.m. - 4:30 p.m
Tuesday, March 14 9:15 a.m. - 4:30 p.m.
Wednesday, March 15 9:15 a.m. - 4:30 p.m.

Research Funding Information Room
Room 336

Monday, March 13 9:30 a.m. - 4:30 p.m
Tuesday, March 14 9:30 a.m. - 4:30 p.m.
Wednesday, March 15 9:30 a.m. - 4:30 p.m.
Closed for Lunch 11:30 a.m. – 12:30 p.m.

Sunday, March 12 - Day 1

CC Levels 300 and 400, 8:15 a.m. to noon
Continuing Education Course: Current Principles for Nonclinical Chronic Toxicity/Carcinogenicity Testing of Environmental Chemicals
Chairperson(s): Kristen Ryan, NIEHS, Durham, NC; and Lynea Murphy, The Dow Chemical Company, Midland, MI.

Introduction and Course Goals.
Kristen Ryan, NIEHS, Durham, NC.

Overview of Pathology for Chronic Toxicity and Carcinogenicity Studies in Rodents.
Mark Cesta, NIEHS, Durham, NC.
CC Levels 300 and 400, 8:15 a.m. to noon
Continuing Education Course: Technologies and Applications of Stem Cells for Use in Toxicology
Chairperson(s): Erik Tokar, NIEHS, Durham, NC; and Aaron Bowman, Vanderbilt University Medical Center, Nashville, TN.

The Fundamentals of Stem Cells for Use in Toxicological Research.
Erik Tokar, NIEHS, Durham, NC.
Hilton Baltimore, Key Ballroom 4, noon to 1:15 p.m.
Tox21: Current Progress, Next Steps and Exploring the Concept of a New Center of Excellent for Predictive Safety
Warren Casey, NIEHS; Reza Rasoulpour, DowAgro Science; Nancy Beck, American Chemistry Council; Greg Akerman, U.S. Environmental Protection Agency
CC Levels 300 and 400, 1:15 to 5:00 p.m.
Continuing Education Course: Developmental and Reproductive Toxicology (DART) and Risk Assessment of Environmental Chemicals: Applications, Complexities, and Novel Approaches
Chairperson(s): Heather Lynch, Gradient, Cambridge, MA; and Natasha Catlin, NIEHS, Durham, NC.
CC Levels 300 and 400, 1:15 to 5:00 p.m.
Continuing Education Course: Read-Across: Case Studies, New Techniques, and Guidelines for Practical Application
Chairperson(s): Kristie Sullivan, Physicians Committee for Responsible Medicine, Oakland, CA; and Mark Cronin, Liverpool John Moores University, Liverpool, United Kingdom.

Improving Read-Across Using Biological Data and Quality Assessment.
Nicole Kleinstreuer, National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), Research Triangle Park, NC.
CC Ballroom III, 4:45 - 6:30 p.m.
Awards Ceremony

Distinguished Toxicology Scholar Award
Linda Birnbaum, Ph.D., NIEHS and NTP Director
Hilton Baltimore Holiday Ballroom 4, 7:30 - 9:30 pm.
Student/Postdoctoral Scholar Mixer

Monday, March 13 - Day 2

CC Room 325, 6:15 - 7:45 a.m.
SOT Mentoring Breakfast
CC Ballroom 1, 9:30 a.m. - 12:15 p.m.
Workshop Session: Fit for Purpose: Using Computational Models for Risk
Chairperson(s): John Wambaugh, US EPA, Research Triangle Park, NC; and Nisha Sipes, NTP/NIEHS, Research Triangle Park, NC.

Abstract 1042
11:04 a.m.
An Intuitive Approach toward Predicting Human Risk with the Tox21 10k Library.
N.S. Sipes1, J.F. Wambaugh2, R. Pearce2, S. Auerbach1, B. Wetmore2, and S. Ferguson1. 1NTP/NIEHS, Research Triangle Park, NC; and 2US EPA, Research Triangle Park, NC.
CC Exhibit Hall, 9;30 a.m. to 12:45 p.m.
Poster Session: Carcinogenesis I
Chairperson(s): Jessica LaRocca, Dow AgroSciences, Indianapolis, IN; and Chad Brocker, NIH, Bethesda, MD.

Abstract 1066, Poster Board P101
Tracing Androgen Metabolism with Inhibition of Aromatase in Breast Cancer: In Vitro Studies and Clinical Correlates.
L.N. Bottalico1,2, C. Mesaros1,2, D. Ciccimaro1,2, N. Snyder3, and I.A. Blair1,2. 1University of Pennsylvania, Philadelphia, PA; 2NIEHS Center of Excellence in Environmental Toxicology, Philadelphia, PA; and 3Drexel University, Philadelphia, PA.

Abstract 1080, Poster Board P115
MiR-31-Mediated Upregulation of CDK1 in Ginkgo biloba Extract-Induced Hepatocellular Carcinomas in B6C3F1/N Mice.
H. Yamashita1,2, S. Surapureddi1, S. Bhusari1, K.R. Shockley1, S.D. Peddada1, K.E. Gerrish1, C.V. Rider1, M.J. Hoenerhoff MJ3, R.C. Sills1, and A.R. Pandiri1. 1NIEHS, Research Triangle Park, NC; 2Taisho Pharmaceutical Co. Ltd., Saitama, Japan; and 3University of Michigan, Ann Arbor, MI.

Abstract 1091, Poster Board P126
Stress Responses Controlled by Circadian Rhythm Is Associated with Susceptibility to Mammary Carcinogenesis.
M. Fang, and H. Zarbl. NIEHS Center for Environmental Exposures and Disease, and Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ.
Poster Session: Carcinogenesis II
Chairperson(s): Mark Miller, NIEHS, Research Triangle Park, NC; and Dhanraj Deshmukh, University of Maryland Baltimore, Baltimore, MD.

Abstract 1103, Poster Board P138
Integrating the Low-Dose Mixture Hypothesis of Carcinogenesis into the Future of Cancer Research.
M. Miller1, W.H. Goodson2, L. Lowe3, M.H. Manjili4, N. Kleinstreuer1, and W.H. Bisson5. 1NIEHS, Research Triangle Park, NC; 2California Pacific Medical Center Research Institute, San Francisco, CA; 3Getting to Know Cancer, Truro, NS, Canada; 4Virginia Commonwealth University Massey Cancer Center, Richmond, VA; and 5Oregon State University, Corvallis, OR.
Poster Session: Reproductive Toxicology
Chairperson(s): David Klein, Brown University, Providence, RI

Abstract 1188, Poster Board P309
A Comparison of In Vivo Reproductive and Developmental Toxicity (DART) Endpoints for Bisphenol AF and Bisphenol A.
V. Sutherland1, B. McIntyre1, K. Pelch1, S. Waidyanatha1, J.M. Conley2, L.E. Gray2, and P.M. Foster1. 1NIEHS, Research Triangle Park, NC; and 2US EPA, Research Triangle Park, NC.

Abstract 1196, Poster Board P317
Development of a UPLC-MS/MS Method to Quantitate 2,2’- Dimorpholinodiethyl Ether (DMDEE) in Rat Plasma, Amniotic Fluid, and Fetus.
V.G. Robinson. NIEHS, Research Triangle Park, NC.

Abstract 1197, Poster Board P318
Low-Dose Developmental Tetrabromobisphenol-a Exposure and Metabolic Changes In Rats.
S.A. Gillera, A. Filgo, G. Kissling, L. Birnbaum, and S. Fenton. NIEHS, Research Triangle Park, NC.
CC Exhibit Hall, 9:30 a.m. to 12:45 p.m.
Poster Session: Developmental and Juvenile Toxicity
Chairperson(s): Daniel Spade, Brown University, Providence, RI; and Brian P. Johnson, University of Wisconsin–Madison, Madison, WI.

Abstract 1228, Poster Board P352
The Dietary Supplement Dimethylaminoethanol Bitartrate Is Not Associated with Neural Tube Defects in Hsd:SD Rats.
B. McIntyre1, H. Cunny1, A. Stokes2, E. Mylchreest2, and P. Foster1. 1NIEHS/National Toxicology Program, Research Triangle Park, NC; and 2Southern Research, Birmingham, AL.

Abstract 1233, Poster Board P357
Pilot Prenatal CD-1 Mouse Developmental Toxicity Studies with the AIDS Drugs Tenofovir Disoproxil Fumarate (TDF), Emtricitabine (FTC), and Efavirenz (EFV) Alone and in Combination: Suggestions of a Toxicokinetic Interaction?
A.L. Dzierlenga1, H. Cunny1, C. Hebert2, L. Miller2, and B.S. McIntyre1. 1National Toxicology Program, Research Triangle Park, NC; and 2Southern Research, Birmingham, AL.

Abstract 1234, Poster Board P358
Application of Signaling Pathway-Based Adverse Outcome Pathways and High-Throughput Human Gestational Toxicokinetic Models for Identification of Putative Developmental Cardiac Toxicants.
S. Hunter1, K. Grode1, M. Rosen1, D. Kapraun1, N. Sipes2, N.C. Baker3, R. Judson1, and T. Knudsen1. 1US EPA, Research Triangle Park, NC; 2NIEHS, Research Triangle Park, NC; and 3Leidos, Research Triangle Park, NC.
Poster Session: Liver: In Vitro and In Silico Approaches
Chairperson(s): Sarah Thacker, University of North Carolina/IDSS, Research Triangle Park, NC; and Shraddha Thakkar, US FDA/NCTR, Jefferson, AR.

Abstract 1242, Poster Board P402
Assessment of the Toxicological Effects of Phenolic Benzotriazoles in an In Vitro Liver Model.
P.E. Dunlap, C. Blystone, J. Rice, S. Ramaiahgari, W. Boyd, S. Ferguson, and M. DeVito. NIEHS, Research Triangle Park, NC.

Abstract 1256, Poster Board P416
Integrating Adverse Outcome Pathways into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury.
L. Wu1, Z. Liu1, S. Auerbach2, R. Huang3, M. Chen1, K. McEuen1, J. Xu1, H. Fang1, and W. Tong1. 1US FDA/NCTR, Jefferson, AR; 2NIH/NIEHS, Research Triangle Park, NC; and 3NIH, Rockville, MD.

Abstract 1257, Poster Board P417
Computationally Predicted Adverse Outcome Pathway Networks for Liver-Related Diseases Using Publicly Available Data Sources: Case Studies and Lessons Learned.
N. Oki1,2, S. Bell3 , M. Angrish2, C. Grant1,2, R. Wang4, and S. Edwards2. 1Oak Ridge Institute for Science Education, Oak Ridge, TN; 2US EPA, Research Triangle Park, NC; 3ILS/ Contractor Supporting NICEATM, Research Triangle Park, NC; and 4US EPA, Cincinnati, OH.
CC Exhibit Hall, 9:30 a.m. - 12:45 p.m.
Poster Session: Epidemiology and Public Health
Chairperson(s): Yudan Wei, Mercer University School of Medicine, Macon, GA; and Lynne Haber, TERA Center, University of Cincinnati, Cincinnati, OH.

Abstract 1297, Poster Board P520
Hypertension in Relation to Dioxins, Polychlorinated Biphenyls, and Pesticides from the Anniston Community Health Survey Follow-Up.
E. Yang1, L. Birnbaum2, and M. Pavuk1. 1ATSDR, Atlanta, GA; and 2NIH, Research Triangle Park, NC.

Abstract 1298, Poster Board P521
Initial Analysis of Liver Disease in the Anniston Community Health Survey-II.
M.C. Cave1, H.B. Clair1, C.M. Pinkston1, K.C. Falkner1, L.S. Birnbaum2, and M. Pavuk3. 1University of Louisville, Louisville, KY; 2NCI/NIH, Research Triangle Park, NC; and 3ATSDR, Atlanta, GA.

Abstract 1299, Poster Board P522
Associations between PCB and Dioxin Exposures with Serum Cytokines in the Anniston Community Health Survey-II.
C.M. Pinkston1, F.A. Middleton2, P.F. Rosenbaum2, H.B. Clair1, K.C. Falkner1, M. Pavuk3, L.S. Birnbaum4, and M.C. Cave1. 1University of Louisville, Louisville, KY; 2SUNY Upstate Medical University, Syracuse, NY; 3ATSDR, Atlanta, GA; and 4NCI/NIH, Research Triangle Park, NC.
Poster Session: Epigenetics
Chairperson(s): Todd A. Townsend, US FDA/NCTR, Jefferson, AR; and Kathleen Gilbert, University of Arkansas for Medical Sciences, Little Rock, AR.

Abstract 1337, Poster Board P628
Detection of Smoking-Associated DNA Methylation Changes in the AHRR Gene Using High-Resolution Melt Method.
A.M. Keshava1,2, M. Wan2, C. Crowl2, M.R. Campbell2, G.S. Pittman2, X. Wang2, and D.A. Bell2. 1Wake Early College of Health and Sciences, Raleigh, NC; and 2NIEHS, Research Triangle Park, NC.
CC Room 340, noon to 1:00 p.m.
Exhibitor-Hosted Session: Developing an Implementation Strategy for Toxicity Testing in the 21st Century
Presented by: National Institute of Environmental Health Sciences
CC Room 310, 12:30 to 1:50 p.m.
Informational Session: Supporting Open Data in Toxicology
Chairperson(s): George M. Woodall, US EPA, Research Triangle Park, NC; and Gary W. Miller, Emory University, Atlanta, GA.

Abtract 1326b
12:35 pm.
Open Data in Biomedical Science: Policy Drivers and Recent Progress.
A. Dearry, NIEHS, Research Triangle Park, NC.
CC Exhibit Hall, 1:15 to 4:30 p.m.
Poster Session: Bioinformatics and Tox Databases
Chairperson(s): Scott Auerbach, NTP/NIEHS, Research Triangle Park, NC; and Michael Madden, US EPA, Research Triangle Park, NC.

Abstract 1365, Poster Board P103
Literature Review of Chemical Factors Affecting Breast Cancer Risk.
J. Stanko, V. Walker, S. Holmgren, and S. Fenton. NIEHS, Research Triangle Park, NC.

Abstract 1381, Poster Board P119
Chemical Effects in Biological Systems (CEBS) Database: Treatment-Related Findings
C. Martini1, A. Rashid1, A. Paleja1, I. Lea1, and J.M. Fostel2. 1ASRC Federal Vistronix, Durham, NC; and 2NIEHS/NIH, Research Triangle Park, NC.

Abstract 1389, Poster Board P127
CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.
K. Mansouri1, N. Kleinstreuer2, E. Watt1, J. Harris1, and R. Judson1. 1US EPA, Research Triangle Park, NC; and 2NIEHS, Research Triangle Park, NC.
Poster Session: Endocrine Toxicology
Chairperson(s): Jone A. Stanley, Texas A&M University, College Station, TX.

Abstract 1499, Poster Board P508
Use of Text-Mining and Machine Learning Approaches to Survey the Literature on Environmental Chemicals and the Thyroid.
B. Kiros1, B.E. Howard2, S. Holmgren1, T. Zoeller3, and K.A. Thayer1. 1NIEHS, Research Triangle Park, NC; 2SciOme LLC, Research Triangle Park, NC; and 3University of Massachusetts Amherst, Amherst, MA.

Abstract 1502, Poster Board P511
Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells.
V.A. Chappell1, A. Janesick2, B. Blumberg2, and S.E. Fenton1. 1NIEHS, Research Triangle Park, NC; and 2University of California Irvine, Irvine, CA.

Abstract 1506, Poster Board P515
Identifying Environmental Chemicals with Potential Adipogenic Activity Using In Vitro High-Throughput Screening Data.
S.E. Fenton1, K.A. Thayer1, W.A. Boyd1, V.A. Chappell1, Y. Chen2, J. Pirone3, A. Tandon3, M.J. DeVito1, and D.G. Allen4. 1NIEHS/NIH, Research Triangle Park, NC; 2US FDA, Laural, MD; 3SciOme, LLC, Research Triangle Park, NC; and 4ILS, Research Triangle Park, NC.

Abstract 1511, Poster Board P520
Androgen Receptor Agonist Identification and Characterization by Screening the Tox21 10K Compound Library.
C. Lynch1, S. Sakamuru1, R. Huang1, D.A. Stavreva2, L. Varticovski2, G.L. Hager2, R.S. Judson3, K.A. Houck3, N.C. Kleinstreuer4, W. Casey4, R.S. Paules4, and M. Xia1. 1NCATS, Rockville, MD; 2National Cancer Institute, Bethesda, MD; 3US EPA, Research Triangle Park, NC; and 4NIEHS, Research Triangle Park, NC.
CC Ballroom I, 1:30 - 2:30 p.m.
Meet the Directors: A Conversation with Linda S. Birnbaum and Robert J. Kavlock
Linda S. Birnbaum, NIEHS, Research Triangle Park, NC; and Robert J. Kavlock, US EPA, Washington, DC.
 
CC Room 321, 2:00 - 4:45 p.m.
Workshop Session: Modernizing Toxicological Risk Assessment for Compounds Released from Pharmaceutical, Consumer, Medical Device and Combination Products: Alternative Tools and Methods
Chairperson(s): Richard Hutchinson, Johnson & Johnson, Somerville, NJ; and Alan Hood, US FDA, Silver Spring, MD.

Abstract 1581
2:05 PM
Evaluation of the Potential Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid (PFOA) with a Systematic Review Framework.
A. Rooney, V. Walker, A. Boyles, and K. Thayer. NIEHS/NTP, Research Triangle Park, NC.
CC Room 308, 2:00 - 4:45 p.m.
Platform Session: Multi-Omic Connections in Chemical Toxicity
Chairperson(s): Jennifer Freeman, Purdue University, IN; and Edward Perkins, US Army ERDC, Vicksburg, MS.

Abstract 1589
3:32 p.m.
High-Dimensional Toxicological Assessment of Chemical Exposure on Physiologically Relevant 3D In Vitro Models.
S.C. Ramaiahgari, S. Waidyanatha, D. Dixon, M.J. DeVito, R.S. Paules, and S.S. Ferguson. NIEHS, Durham, NC.

Abstract 1590
3:55 p.m.
Organotypic HepaRG Cultures (384-well) and High-Throughput Transcriptomics with 112 Compounds to Model Human Liver and Characterize Compound-Induced Biological-Response “Space.”
S. Ferguson, S. Ramaiahgari, J. Rice, P. Dunlap, S. Smith-Roe, K. Witt, S. Auerbach, A. Merrick, M. DeVito, and R. Paules. NIEHS/NIH, Research Triangle Park, NC.

Tuesday, March 14 - Day 3

CC Room 308, 9:30 a.m. to 12:15 p.m.
Platform Session: Endocrine Toxicology
Chairperson(s): Chairperson(s): Suzanne E. Fenton, NIEHS/DNTP, Research Triangle Park, NC; and Majorie van Duursen, Utrecht University, Utrecht, Netherlands.

Abstract 1633
9:53 a.m.
Blinded Evaluation of Potential Obesogens in Murine 3T3-L1 Preadipocytes following Selection from Database Results.  
M. Bharadwaj1, V.A. Chappell1, K.A. Thayer1, J. Rice1,
D.G. Allen2, W.W. Polk2, and S.E. Fenton1. 1NIEHS, Research Triangle Park, NC; and 2Integrated Laboratory Systems, Inc., Durham, NC.

Abstract 1636
11:02 a.m.
Identification of Androgen Receptor Antagonists Using Tox21 qHTS Data and the MARCoNI Assay.
A. Bone1, M. Xia2, S. Sakamuru2, R. Huang2, R. Houtman3, R. van Beuningen3, E. Watt1, N. Kleinstreuer4, R. Judson1, and K. Houck1. 1US EPA, Research Triangle Park, NC; 2National Center for Advancing Translational Sciences (NIH), Rockville, MD; 3Pamgene, ertogenbosch, Netherlands; and 4NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NIH), Research Triangle Park, NC.
CC Exhibit Hall, 9:30 a.m. to 12:45 p.m.
Poster Session: Neurotoxicology: General Neurotoxicity
Chairperson(s): Prasada S. Kodavanti, US EPA, Research Triangle Park, NC; and Jasmine Brown, US EPA, Research Triangle Park, NC.

Abstract 1724, Poster Board P209
Dysregulation of Pro-Inflammatory and Anti-Inflammatory Activation in Murine Microglia following Arsenic Exposure.
 C. McPherson, and J. Harry. NIEHS, Research Triangle Park, NC.

Abstract 1744, Poster Board P229
Lipid Signaling Pathways Regulate Xenobiotic Efflux Transport Activity at the Blood-Brain Barrier.
R.E. Cannon, R.A. Evans, E. Mesev, and D.B. Banks. NIEHS, Research Triangle Park, NC.
CC Exhibit Hall, 9:30 a.m. to 12:45 p.m.
Poster Session: Dose-Response Assessment and Toxicity Reference Value Derivation
Chairperson(s): Anne E. Loccisano, Exponent, Alexandria, VA; and Mara Seeley, Gradient, Cambridge, MA.

Abstract 1828, Poster Board P402
The Impact of Generalized Informative Priors on Benchmark Dose Estimation.
  K. Shao1, and
A. Shapiro2. 1Indiana University, Bloomington, IN; and 2National Toxicology Program, Research
Triangle Park, NC.
Poster Session: Exposure Assessment and Biomonitoring

Abstract 1905, Poster Board P529
Hepatic, Cardiovascular, and Other Biomarkers Associated with Organics and Metals Exposure in Female Vietnamese Electronic Waste Workers and Comparisons. 
A.J. Schecter1,2, J.S. Kincaid1, H. Clair1, M. Cave1, A. Bhatnagar1, D. Riggs1, and L. Birnbaum3. 1University of Louisville School of Medicine, Louisville, KY; 2University of Louisville School of Public Health and Information Sciences, Louisville, KY; and 3National Cancer Institute, National Institutes of Health, Research Triangle Park, NC.
Poster Session: Immunotoxicology
Chairperson(s): Peer Karmaus, St. Jude Children’s Research Hospital, Memphis, TN; and Jessica Meyers, University of Rochester, Rochester, NY.

Abstract 1959, Poster Board P629
Immunotoxic Effects of Perfluoro-n-decanoic Acid on Female Harlan Sprague-Dawley Rats and B6C3F1/N Mice When Administered by Oral Gavage.  R. Frawley1, M. Smith2, M. Cesta1, S. Hayes-Bouknight3, C. Blystone1, G. Kissling1, and D. Germolec1. 1NIEHS, Research Triangle Park, NC; 2Richard Bland College of William and Mary, Petersburg, VA; and 3Charles River Laboratories, Inc., Durham, NC.

Abstract 1971, Poster Board P641
Immunotoxicity of Benzo(a)pyrene and Phenanthrene. V.J. Johnson1, C.V. Rider2, M.I. Luster1, E. Mutlu2, S. Waidynatha2, G.R. Burleson1, F.G. Burleson1, and D.R. Germolec2. 1Burleson Research Technologies, Inc., Morrisville, NC; and 2National Toxicology Program, NIEHS, Research Triangle
Park, NC.

Abstract 1976, Poster Board P646
Assessment of Immunotoxicity in Female F344/N and Sprague Dawley Rats and Female B6C3F1 Mice Exposed to Hexavalent Chromium via the Drinking Water., K.A. Shipkowski1, C.M. Sheth2, M.J. Smith3, M.J. Hooth1, and D.R. Germolec1. 1National Toxicology Program, NIEHS Research Triangle Park, NC; 2US FDA/CDER, Silver Spring, MD; and 3Richard Bland College of William and Mary, Petersburg, VA.
CC Room 324, noon to 1:15 p.m.
Postdoctoral Assembly Luncheon
Chairperson(s): Gabriel Knudsen, National Cancer Institute at NIEHS, Research Triangle Park, NC.
CC Exhibit Hall, 1:15 to 4:30 p.m.
Poster Session: Regulation and Policy
Chairperson(s): Robinan Gentry, Ramboll Environ, Monroe, LA; and Bernard Gadagbui, Toxicology Excellence for Risk Assessment (TERA) Center, Cincinnati, OH.

Abstract 2182, Poster Board P447
Replacing Animals for Acute Systemic Toxicity Testing: A US Strategy and Roadmap.
A. Lowit1, C. Schlosser1, A. Myska2, G. Patlewicz3, M. Paris4, A. Karmaus4, J. Strickland4, D. Allen4, N. Kleinstreuer5, and W. Casey5. 1US EPA, Washington, DC; 2DOD/DTRA, Ft. Belvoir, VA; 3US EPA, Research Triangle Park, NC; 4ILS, Research Triangle Park, NC; and 5NIEHS, Research Triangle Park, NC.
Poster Session: The Developmental Basis of Adult Disease
Chairperson(s): Asok K. Dasmahapatra, University of Mississippi, University, MS; and Jessica S. Plavicki, Brown University, Providence, RI.

Abstract 2226, Poster Board P541
Temporal Microvascular and Mitochondrial Implications of Prenatal Nano-TiO2 Exposure.
P. Stapleton1, A. Abukabda2, C. Nichols3, Q. Hathaway2, S. Rellick2, C. McBride2, J. Yi2, J. Hollander2, and T. Nurkiewicz2. 1Rutgers University, Piscataway, NJ; 2West Virginia University, Morgantown, WV; and 3NIEHS, Durham, NC.

Abstract 2228, Poster Board P543
Differential Gene Expression and Pathway Analysis in an Adult Japanese Population Exposed to Inorganic Arsenic in Early Childhood.
E. Tokar1, A. Merrick1, D. Phadke1, R. Shah1, M. Waalkes1, P. Grandjean2, and T. Yorifuji3. 1NIEHS, Research Triangle Park, NC; 2Harvard School of Public Health, Boston, MA; and 3Okayama University, Okayama, Japan.
Poster Session: Biotransformation
Chairperson(s): Hartmut Jaeschke, University of Kansas Medical Center, Kansas City, KS; and Marie C. Fortin, Colgate-Palmolive, Piscataway, NJ.

Abstract 2236, Poster Board P551
Xenobiotic Metabolism Benchmarking of Tox21 Cell Lines.
W. Qu, M. DeVito, and S. Ferguson, NIEHS, Research Triangle Park, NC.
CC Room 324, 1:20 to 2:40 p.m.
Career Exploration through Speed Informational Interviews
Chairperson(s): Natasha Catlin, NIEHS-NTP, Research Triangle Park, NC; and Alexandra Noël, Louisiana State University, Baton Rouge, LA.
Co-Chairperson(s):Gabriel Knudsen, NCI, Research Triangle Park, NC; Samantha McNeal, University of South Carolina, Columbia, SC; Daniel Spade, Brown University, Providence, RI; Christopher Stewart, MPI Research, Mattawan, MI.
CC Ballroom III, 2:00 to 4:45 p.m.
Symposium Session: Chemically-Induced Neuroinflammation and “Sickness Behavior” Disorders
Chairperson(s): James O’Callaghan, CDC/NIOSH, Morgantown, WV; and G. Jean Harry, NIEHS/NIH, Research Triangle Park, NC.

Abstract 2292
2:00 p.m.
Introduction.
G. Harry. NIEHS/NIH, Research Triangle Park, NC

.Abstract 2293
2:05 p.m.
Overview of Neuroinflammation and Sickness Behavior.
C.A. McPherson. NIEHS/NIH, Research Triangle Park, NC.
CC Room 314, 2:00 to 4:45 p.m.
Platform Session: Particulate Matter and Cardiovascular Impairment
Chairperson(s): William K. Martin, Oak Ridge Institute for Science and Education, Raleigh, NC; and John G. Lamb, University of Utah, Salt Lake City, UT.

Abstract 2328
2:23 p.m.
Ambient Particulate Matter Induces Mouse Pulmonary Pathological Vascular Remodeling and Vascular Smooth Muscle Cell Dysfunctions.
P. Lin1, C. Ho1, Y. Chen1, H. Tsai1, M. Tsai1, and S. Yet2. 1National Institutes of Environmental Health Sciences, National Health Research Institutes,Zhunan, Taiwan; and 2Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan.
CC Room 340, 3:00 to 4:00 p.m.
Exhibitor-Hosted Session: Trends, Trials, and Triumphs in In Vitro Toxicology
Presented by: Charles River and National Institutes of Environmental Health Sciences

Wednesday, March 15 - Day 4

CC Exhibit Hall, 9:30 a.m. to 12:45 p.m.
Poster Session: Respiratory Toxicology
Chairperson(s): Kristen Ryan, National Toxicology Program, Durham, NC; and Alexandra Noël, Louisiana State University, Baton Rouge, LA.

Abstract 2399, Poster Board P123
Comparative Respiratory Tract Toxicity and Carcinogenicity of Metalworking Fluids in Rats and Mice following Chronic Inhalation Exposure.
K.R. Ryan1, M. Cesta1, R. Herbert1, K. Janardhan2, G. Kissling1, and D.L. Morgan1. 1NIEHS, Durham, NC; and 2ILS Inc, Durham, NC.

Abstract 2404, Poster Board P128
Acute Inhalation Toxicity of Trimethylsilyldiazomethane in Harlan Sprague Dawley Rats and B6C3F1/N Mice. 
W.M. Gwinn1, S. Waidyanatha1, D. Dixon1, R. Barnewall2, K. Patton2, B. Hayden2, J. Richey2, and M.D. Stout1. 1NIEHS, Research Triangle Park, NC; and 2Battelle, Columbus, OH.
Poster Session: Air Pollution
Chairperson(s): Andres Henriquez, University of North Carolina at Chapel Hill, Chapel Hill, NC; and Lance M. Hallberg, University of Texas Medical Branch, Galveston, TX.

Abstract 2442b, Poster Board P168
Comparative Inhalation Toxicity of Ethyltoluene Isomers in Rats and Mice. 
G.K. Roberts1, C.J. Willson2, D. Olivera3, D.E. Malarkey1, and D.L. Morgan1. 1National Toxicology Program, Durham, NC; 2Integrated Laboratory Systems, Inc., Durham, NC; and 3Alion Science and Technology Corporation, Durham, NC.
Poster Session: Persistent Organic Pollutants
Chairperson(s): Mary K. Walker, University of New Mexico, Albuquerque, NM.

Abtract 2464, Poster Board P224
Identifying Responders to Tetrabromobisphenol A (TBBPA) Using Marker Genes following Repeat Oral Administration in Wistar Han Rats.
  S.M. Hall, S.J. Coulter, G.A. Knudsen, and L.S. Birnbaum. National Cancer Institute, Research Triangle Park, NC.

Abstract 2477, Poster Board P237
Polychlorinated Biphenyls and Relative Telomere Length in the Anniston Community Health Survey. 
C.L. Callahan1, M. Pavuk2, X. Ren3, L.S. Birnbaum4, J.R. Olson3, and M.R. Bonner3. 1National Cancer Institute, Bethesda, MD; 2CDC, Atlanta, GA; 3University at Buffalo, Buffalo, NY; and 4NCI at NIEHS, Research Triangle Park, NC.
CC Exhibit Hall, 9:30 a.m. to 12:45 p.m.
Poster Session: Disposition/Pharmacokinetics
Chairperson(s): Daniel R. Dietrich, University of Konstanz, Konstanz, Germany; and Wei Qu, NIEHS, Research Triangle Park, NC.

Abstract 2483, Poster Board P245
Toxicokinetics of Sulfolane in Male and Female Harlan Sprague Dawley Rats and B6C3F1/N Mice Following Oral Gavage Administration.
  T.R. Fennell1, S. Black1, P. Patel1, T. Uenoyama1, B.L. Fletcher1, S.D. Cooper1, M.A. Rehder Silinski1, R.A. Fernando1, V. Godfrey Robinson2, C.R. Blystone1, and S. Waidyanatha1. 1RTI International, Research Triangle Park, NC; and 2National Toxicology Program/NIEHS, Research Triangle Park, NC.

Abstract 2489, Poster Board P251
Maternal Pharmacokinetic and Fetal Disposition of Bisphenol Analogues in the CD-1 Mouse.
 D.K. Tucker1, F. Lih2, and S.E. Fenton2. 1University of North Carolina at Chapel Hill, Cary, NC; and 2NIEHS, Research Triangle Park, NC.

Abstract 2490, Poster Board P252
Tetrabromobisphenol A Disposition and Kinetics in Pregnant and Nursing Wistar Han Rats.
G.A. Knudsen, S.M. Hall, A.C. Richards, and L.S. Birnbaum. NCI, Research Triangle Park, NC.
Poster Session: Liver 1: Mechanisms and Translational Biomarkers
Chairperson(s): Hartmut Jaeschke, University of Kansas Medical Center, Kansas City, KS; and Anna Kopec, Michigan State University, East Lansing, MI

.Abstract 2503, Poster Board P310
Differential Expression of Novel lncRNAs after Genotoxicant Exposure. 
B.A. Merrick1, D.P. Phadke2, and R.R. Shah2. 1NIEHS, Research Triangle Park, NC; and 2Sciome, LLC, Research Triangle Park, NC.
Poster Session: Liver 2: Mechanisms and Translational Biomarkers
Chairperson(s): James Luyendyk, Michigan State University, East Lansing, MI.

Abstract 2541b, Poster Board P349
Gene Expression Profiling of Primary Human Hepatocyte Inter-Individual Variance in Adaptive Stress Response Activation. 
S. Huppelschoten1, M. Niemeijer1, W. den Hollander1, A. Baze2, C. Parmentier2, R. Paules3, L. Richert2, and B. van de Water1. 1Leiden University, Leiden, Netherlands; 2Kaly Cell, Strassbourg, France; and 3NIH/NIEHS, Research Triangle Park, NC.
CC Exhibit Hall, 9:30 a.m. to 12:45 a.m.
Poster Session: Clinical and Translational Toxicology
Chairperson(s): Shuaizhang Li, NIH/NCATS, Rockville, MD; and Meghan Rebuli, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Abstract 2542, Poster Board P351
Urinary Kidney Toxicity Biomarker Performance in an Outbred Mouse Population Exposed to Cisplatin.
  H. Lin1, J. Tobacyk1, S. Luo1, and A. Harrill1,2. 1University of Arkansas for Medical Sciences, Little Rock, AR; 2National Toxicology Program, Durham, NC.
Poster Session: Natural Products
Chairperson(s): Nikolay M. Filipov, University of Georgia, Athens, GA.

Abstract 2603, Poster Board P44
8A Toxicological Evaluation of Goldenseal In Vitro Using Primary Human Hepatocytes. 
J.R. Rice, W.A. Boyd, P.E. Dunlap, J.K. Dunnick, S.S. Ferguson, S. Ramaiahgari, and M.J. Devito. NIEHS, Durham, NC.
Poster Session: Pesticides
Chairperson(s): Puttappa Dodmane, CalEPA/DPR, Sacramento, CA; and Sean Gehen, Dow Agrosciences, Indianapolis, IN.

Abstract 2658, Poster Board P551
Formulation Development and Validation of an Analytical Method for Analysis of Pyridine, 2-(1-methyl-2-(4-phenoxyphenoxy) ethoxy) (Pyriproxyfen) in Support of Rodent Toxicology Studies.
 J.C. Blake1, J. Gilliam1, J. Thadani1, D.B. Browning1, R.A. Price1, R.A. Fernando1, V.G. Robinson2, B. McIntyre2, and S. Waidyanatha2. 1RTI International, Research Triangle Park, NC; and 2Division of the National Toxicology Program, Research Triangle Park, NC.
Poster Session: Nanotoxicology: Carbon-Based Nanomaterials
Chairperson(s): Salik Hussain, NIEHS/NIH, Research Triangle Park, NC; and Alexei Basnakian, University of Arkansas for Medical Sciences, Little Rock, AR.

Abstract 2709, Poster Board P637
Inhalation Exposure to Multi-Walled Carbon Nanotubes Reduces TH2 Immune Responses in a House Dust Mite Model of Asthma.
  M.D. Ihrie1, A.J. Taylor1, G.L. Baker2, M.D. Stout3, K.S. Duke1, and J.C. Bonner1. 1North Carolina State University, Raleigh, NC; 2Battelle, West Jefferson, OH; and 3National Toxicology Program, Research Triangle Park, NC.

Abstract 2713, Poster Board P641
Pristine and Carboxylic Acid Functionalized Multi-Walled Carbon Nanotubes Induce Pulmonary Injury Through Distinct Mechanisms.
  S. Hussain1, A. Taylor2, L. Miller-Degraff1, R. Snyder1, M. George1, J. Marshburn1, A. Rice1, J. Bonner2, and S. Garantziotis1. 1NIEHS/NIH, Research Triangle Park, NC; and 2North Carolina State University, Raleigh, NC.

Abstract 2716, Poster Board P644
Impaired Ciliogenesis in Differentiating Human Bronchial Epithelia Exposed to Nontoxic Doses of Multi-Walled Carbon  Nanotubes. 
R.J. Snyder1, S. Hussain1, C.J. Tucker1, S.H. Randell2, and S. Garantziotis1. 1NIEHS, Durham, NC; and 2University of North Carolina Chapel Hill, Chapel Hill, NC.
CC Room 321, 12:30 to 1:20 p.m.
Distinguished Toxicology Scholar Award Lecture — Dioxins and the Ah Receptor: Synergy of Discovery
Presented by:  Linda S. Birnbaum, NIEHS and NTP Director
CC Room 309, 12:30 to 1:50 p.m.
Roundtable Session: Herbo-Metallic Mixtures in Traditional Medicines
Chairperson(s): J. Christopher States, University of Louisville, Louisville, KY; and Jie Jerry Liu, Zunyi Medical College, Zunyi, China.

Abstract 2729
12:50 p.m.
Understanding Chemical and Biological Similarity across Complex Mixtures in Hazard Characterization of Botanical Dietary Supplements.
C.V. Rider. NIEHS-NTP, Research Triangle Park, NC.
CC Room 310, 12:30 to 1:50 p.m.
Historical Highlights Session: NIEHS Superfund Research Program: A History of Cutting-Edge Science and Innovative Technologies
Chairperson(s): Danielle Carlin, NIEHS, Research Triangle Park, NC; and Rebecca Fry, University of North Carolina-Chapel Hill, Chapel Hill, NC.

Abstract 2732
12:30 p.m.
NIEHS Superfund Research Program: A History of Cutting-Edge Science and Innovative Technologies. 
W. Suk. NIEHS, Research Triangle Park, NC.

1:20 p.m.
Emerging Prevention Paradigms with Nutrition: The Impact of the NIEHS SRP. 
B. Hennig. University of Kentucky, Lexington, KY.
CC Exhibit Hall, 1:15 to 4:30 p.m.
Poster Session: Alternatives to Mammalian Models II
Chairperson(s): Daniel R. Dietrich, University of Konstanz, Konstanz, Germany; and Tetyana Kobets, New York Medical College, Valhala, NY.

Abstract 2792, Poster Board P160
Toxicity Profiling Using a Battery of Assays in Zebrafish Embryos Including Teratogenicity, Behavior, Cardiotoxicity, Ototoxicity, and Hepatotoxicity.
  C. Quevedo1, A. Alzualde1, A. Alday1, I. Irijalba1, O. Holgado1, A. Muriana1, K. Ryan2, R.S. Paules2, and M. Behl2. 1BIOBIDE-Bionaturis Group, San Sebastian, Spain; and 2NIEHS/NIH, Durham, NC.
Poster Session: Quantitative Systems Toxicology
Chairperson(s): Susanne Ramm, Harvard Medical School, Boston, MA; and Jason B. Harris, US EPA/ORISE, Knoxville, TN

Abstract 2913, Poster Board P407
Comparative Genomic Dose Response Studies of Microcystin-LR and -LA.
  T.O. Saddler1, M.J. Devito1, N.J. Walker1, N.J. Machesky2, M.K. Vallant1, and S.S. Auerbach1. 1NIEHS, Research Triangle Park, NC; and 2Battelle, Columbus, OH.

Abstract 2915, Poster Board P409
Prediction of Skin Sensitization Potency Using Machine Learning Approaches.
  J. Strickland1, Q. Zang1, M. Paris1, D. Lehmann2, S. Bell1, D. Allen1, J. Matheson3, A. Jacobs4, W. Casey5, and N. Kleinstreuer5. 1ILS, Research Triangle Park, NC; 2US EPA, Research Triangle Park, NC; 3CPSC, Rockville, MD; 4US FDA/CDER, Silver Springs, MD; and 5NIEHS, Research Triangle Park, NC.

Abstract 2918, Poster Board P412
Benchmark Dose Analysis of Chemical Effects in Biological Systems (CEBS) Datasets
.  I. Lea1, L. Yang1, A. Rashid1, and J.M. Fostel2. 1ASRC Federal Vistronix, Durham, NC; and 2NIEHS, Research Triangle Park, NC.

Abstract 2919, Poster Board P41
Comparison of Metrics of Chemical Similarity in High-Throughput Assays.
  F. Parham1, S. Auerbach1, J. Hsieh1, and D. Svoboda2. 1NIEHS, Research Triangle Park, NC; and 2Sciome, Research Triangle Park, NC.

Abstract 2922, Poster Board P416
Evaluation of Parameter Settings in Genomic Benchmark Dose Analysis That Minimize False Discovery and Maximize Reproducibility.
  S.S. Auerbach1, J. Phillips2, D.L. Svoboda2, L. Yang3, B. Kuo4, R.S. Thomas5, C.L. Yauk6, R.R. Shah2, and R.S. Paules1. 1NTP/NIEHS, Research Triangle Park, NC; 2Sciome LLC, Research Triangle Park, NC; 3Vistronix, Research Triangle Park, NC; 4Health Canada, Ottawa, NC, Canada; 5US EPA, Research Triangle Park, NC; and 6Health Canada, Ottawa, ON, Canada.

Abstract 2935, Poster Board P429
An Integrated Chemical Environment to Support 21st Century Toxicology.
  S. Bell1, J. Phillips2, A. Sedykh2, C. Sprankle1, S. Morefield1, D. Allen1, W. Casey3, and N. Kleinstreuer3. 1ILS, Research Triangle Park, NC; 2Sciome, Research Triangle Park, NC; and 3NIEHS, Research Triangle Park, NC.
CC Room 337, 1:30 to 2:30 p.m.
Exhibitor-Hosted Session: ICCVAM Tools for Validation and Regulatory Application of Alternative Methods
Presented by:  National Institutes of Environmental Health Sciences and the National Toxicology Program
CC Room 316, 2:00 to 4:45 p.m.
Symposium Session: Increasing Confidence in Safety Assessment Decisions: The Inclusion of Metabolism in Toxicity Testing Strategies
Chairperson(s): Miyoung Yoon, ScitoVation, LLC, Research Triangle Park, NC; and Stephen Ferguson, NIEHS, Research Triangle Park, NC.

Abstract 3069
3:06 p.m.
Incorporating Improved Physiological Relevance, Xenobiotic Metabolism, and Data-Rich Assay Approaches into Tox21 (Phase III).
S. Ferguson, and S. Ramaiahgari. NTP, NIEHS, Research Triangle Park, NC.
CC Ballroom IV, 2:00 to 4:45 p.m.
Symposium Session: Novel In Vitro and In Silico Platforms for Modeling Developmental and Reproductive Toxicity
Chairperson(s): Thomas B. Knudsen, US EPA, Research Triangle Park, NC; and Nicole C. Kleinstreuer, NIEHS, Research Triangle Park, NC.

Abstract 3074
2:37 p.m.
Pathway Based Models to Predict Developmental and Reproductive Toxicities. 
N.C. Kleinstreuer. NIEHS, Research Triangle Park, NC
CC Ballroom II, 2:00 to 4:45 p.m.
Workshop Session: Is There a Concern for Neurotoxicity from Replacement Organophosphorus Flame-Retardants?: Insights Using Molecular Approaches, Systems Biology, and Human Exposure
Chairperson(s): Helena T. Hogberg, Johns Hopkins University, Baltimore, MD; and Mamta Behl, NTP/NIH, Research Triangle Park, NC.

Abstract 3095
3:50 p.m.
Putting It into Perspective: Relating Experimental Data to Human Exposure—Is Neurotoxicity Really a Concern?
M. Behl, NTP/NIH, Research Triangle Park, NC.
CC Room 314, 5:00 to 6:20 p.m.
Informational Session: Addressing Rigor and Transparency in Research and Journal Publications
Chairperson(s): Sally P. Darney, NIEHS, Research Triangle Park, NC; and Nancy B. Beck, American Chemistry Council, Washington, DC.

Abstract 3097
5:00 p.m.
Addressing Rigor and Transparency in Research and Journal Publications. Introduction. 
S.P. Darney. NIEHS, Research Triangle Park, NC.

Abstract 3097
5:50 p.m.
Interdisciplinary Challenges for Rigor and Reproducibility in Environmental Health Research
. S.P. Darney. NIEHS, Research Triangle Park, NC.

Thursday, March 16 - Day 5

CC Ballroom I, 8:30 to 11:15 a.m.
Symposium Session: Evaluating the Reproductive and Developmental Effects of Botanical Dietary Supplements
Chairperson(s): Kembra L. Howdeshell, NIEHS/NTP, Research Triangle Park, NC; and Cynthia V. Rider, NIEHS/NTP, Research Triangle Park, NC.

Abstract 3100
8:30 a.m.
Introduction.
K . Howdeshell. NIEHS, Research Triangle Park, NC.

Abstract 3103
9:39 a.m.
Embryo-Fetal Toxicity in the Rat and Rabbit as a Result of Dietary Supplement Exposure: Vinpocetine as a Case Study. 
N. Catlin. NIEHS/NTP, Research Triangle Park, NC.
CC Room 321, 8:30 to 11:15 a.m.
Symposium Session: Quantitative Systems Toxicology for Chemical Safety Assessment
Chairperson(s): Bob van de Water, Leiden University, Leiden, Netherlands; and Richard S. Paules, NIEHS, Research Triangle Park, NC.

Abstract 3114
9:05 a.m.
Implementing Approaches for Moving Tox21 towards Quantitative Systems Toxicology. 
R.S. Paules. NIEHS, Research Triangle Park, NC.

11:05 a.m.
Concluding Remarks. 
R.S. Paules. NIEHS, Research Triangle Park, NC.
CC Hall A, 8:30 to 11:45 a.m.
Poster Session: Alternatives to Mammalian Models III
Chairperson(s): Michael Fasullo, SUNY Polytechnic Institute, Albany, NY; and Michelle Angrish, US EPA, Cary, NC.

Abstract 3159, Poster Board P118
Development of a Curated Database of In Vivo Developmental Toxicity Data. 
P. Ceger1, N. Choksi1,J. Hamm1, J. Truax1, A. Daniel1, D. Allen1, V. Sutherland2, B. McIntyre2, P. Foster2, E. Maull2, andW. Casey2. 1ILS, Research Triangle Park, NC; and 2NIEHS, Research Triangle Park, NC.

Abstract 3160, Poster Board P119
Evaluating Defined Approaches to Testing and Assessment of Skin Sensitization Potential.
N. Kleinstreuer1, J. Strickland2, V. Zuang3, A. Lowit4, J. Matheson5, D. Allen2, W. Casey1, and M. Whelan3. 1NIEHS, Research Triangle Park, NC; 2ILS, Research Triangle Park, NC; 3European Commission, Ispra, Italy; 4US EPA, Washington, DC; and 5CPSC, Rockville, MD.

Abstract 3161, Poster Board P120
SEAZIT: The National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology. 
J. Hamm1, P. Ceger1, E. Maull2, S. Padilla3, E. Perkins4, A. Planchart5, D. Stedman6, T. Tal7, R. Tanguay8, D. Volz9, G. Baker10, M. Stout2, and N. Walker2. 1ILS, Research Triangle Park, NC; 2NIEHS, Research Triangle Park, NC; 3US EPA, Research Triangle Park, NC; 4US Army Engineer R&D Center, Vicksburg, MS; 5North Carolina State University, Raleigh, NC; 6Pfizer, Inc, Groton, CT; 7US EPA, Research Triangle Park, NC; 8Oregon State University, Corvallis, OR; 9University of California Riverside, Riverside, CA; and 10Battelle, West Jefferson, OH.

Abstract 3163, Poster Board P122
Identification of Environmental Chemicals with Potential Roles in Obesity and Diabetes Using Animal Studies from US EPA and NTP Toxicological Databases. 
W.A. Boyd1, J.R. Pirone2, M.P. Shaw3,N.C. Kleinstreuer1, M.T. Martin4, A. Rashid3, J.M. Fostel1, and K.A. Thayer1. 1NIEHS, Research Triangle Park, NC; 2Sciome LLC, Research Triangle Park, NC; 3ASRC Federal Vistronix, Morrisville, NC; and4US EPA, Research Triangle Park, NC.
Poster Session: Biological Modeling
Chairperson(s): Elaina M. Kenyon, US EPA, Durham, NC; and Robin McDougall, AstraZeneca, Waltham, MA.

Abstract 3185, Poster Board P144
Open Source Workflows for In Vitro to In Vivo Extrapolation. 
X. Chang1, S. Bell1, J. Pirone2, D. Allen1,W. Casey3, and N. Kleinstreuer3. 1ILS, Research Triangle Park, NC; 2ARA, Raleigh, NC; and 3NIEHS, Research Triangle Park, NC.
CC Hall A, 8:30 to 11:45 a.m.
Poster Session: Emerging Technologies
Chairperson(s): Laura M. Patrone, Bristol-Myers Squibb, New Brunswick, NJ.

Abstract 3205, Poster Board P173
Assessment of In Silico-Designed Probes for Rat Whole Exome Sequencing. 
J.F. Foley1, R.R. Shah2, D.P. Phadke2, A. Cua3, S. Hardy3, V. Miller3, G.G. Solomon1, A.R. Pandiri1, R.A. Herbert1, R.C. Sills1, and B.A. Merrick1. 1NIEHS, Research Triangle Park, NC; 2Sciome, LLC, Research Triangle Park, NC; and 3Agilent Technologies, Santa Clara, CA.

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