A Toxicology User's Guide to the Roadmap Epigenomics and ENCODE Data Resources (SOT 2016 Satellite Meeting)
March 17, 2016
Improvements in DNA sequencing technologies have resulted in an exponential increase in the amount of genomic and epigenomic data available.
Some of these data have been generated as part of large-scale, focused mapping efforts aimed at understanding how genes are regulated, such as the NIH Roadmap Epigenomics Program, and ENCODE (Encyclopedia of DNA Elements). Efforts such as these can be extremely valuable for hypothesis generation and data mining, but can only be useful if one knows what is available and how to use it.
This SOT satellite meeting provided toxicology researchers with an overview of these two NIH-funded programs, introduced attendees to the informatics tools that have been developed to help navigate these large datasets, and walked through several use cases.
The meeting was of broad interest to researchers interested in learning more about how environmental exposure might impact gene regulation.