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Your Environment. Your Health.

Children's Environmental Health Research: Past, Present & Future

January 22-23, 2007

Boy holding a basketball

Workshop Overview

The goal of this workshop is to develop new strategies for research, exposure and effects monitoring, intervention and prevention in children's environmental health. Specific objectives are to maximize the effectiveness of scientific research - basic science, exposure monitoring/biomonitoring, epidemiology, toxicology, clinical medicine and multidisciplinary studies - and to enhance the translation of research to the bedside, to the community and to public policy. The first day will begin with discussions of two case studies that demonstrate the successful implementation of evidence-based intervention/prevention strategies that became possible once links between environmental exposures and a disease in children had been identified.

The first case study will focus on lead and neurotoxicity. Findings on the adverse effects of lead on neurodevelopment ultimately led to efforts to reduce exposures to lead. Asthma will be used as a second case study because it provides a clear example of environmental triggers and some science-based prevention/intervention strategies that are already being implemented. The second day of the workshop will focus on applying lessons learned from the two "success" case studies to two children's disorders that appear to have environmental etiologies but are less well understood: disorders of lipid and carbohydrate metabolism and attention deficit/hyperactivity disorder (ADHD).

A discussion will follow each case study presentation to consider the opportunities, the barriers and the design challenges that confront future clinical, toxicological, epidemiological, exposure monitoring, and basic research in children's environmental health. Specific topics include:

  • Past approaches to research translation to see what worked and what failed to work.
  • The critical mass of researchers and mix of disciplines needed to most efficiently advance research in children's environmental health.
  • Biomarkers of exposure, susceptibility, or subclinical dysfunction.
  • The use of "omics" technologies that might be incorporated into future toxicological, epidemiological and/or biomonitoring studies to enhance their sensitivity and efficiency.
  • Is there a point at which the use of new scientific tools might slow the pace of progress?
  • New approaches to accelerating the translation of science to treatment, prevention, and the remediation of environmental risks to children's health.
  • Potential study populations at uniquely high risk of disease.
  • Data resources - records, disease registries, well-characterized cohort populations, tissue banks, or stored DNA - in the U.S. or abroad that might facilitate future studies.
  • New partnerships in research.

This meeting is open to the public with time set aside for public discussion.

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8:30 Welcome and Charge David Schwartz, M.D. (NIEHS) and Christopher Portier, Ph.D. (NIEHS)
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  Introduction Phil Landrigan View Presentation(404KB)
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Session 1: Lead and Neurotoxicity Session Chair: Annette Kirshner, Ph.D. (NIEHS)
9:00-9:30 Epidemiology Bruce Lanphear, M.D. (Cincinnati Children's Hospital Medical Center) View Presentation(580KB)
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9:30-10:00 Basic Science/Toxicology Tomas Guilarte, Ph.D. (John Hopkins U) View Presentation(773KB)
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10:00-10:30 Intervention/Prevention Joseph Graziano, Ph.D. (Columbia U) View Presentation(2MB)
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10:30-10:45 Break  
10:45-12:15 Discussion Howard Hu, M.D. (U of Michigan)
Herb Needleman, M.D. (U of Pittsburgh) View Presentation(773KB)
Walter Rogan, M.D. (NIEHS)
Mary Ann Wilson, Ph.D. (John Hopkins U)
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12:15-1:15 Lunch  
Session 2: Asthma Session Chair: Harold Zenick, Ph.D. (EPA)
1:15-1:45 Epidemiology Ralph Delfino, M.D., Ph.D. (U California - Irvine) View Presentation(3MB)
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1:45-2:15 Basic Science/Toxicology David Diaz-Sanchez, Ph.D. (U California - Los Angeles) View Presentation(1MB)
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2:15-2:45 Human Intervention/Prevention Thomas Matte, M.D., M.P.H. (New York City Department of Health & Mental Hygiene) View Presentation(167KB)
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2:45-3:15 Break  
3:15-5:15 Discussion and Closing Comments Stephanie London, M.D., DrPH (NIEHS)
Paul Garbe, DVM, MPH (CDC)
James Seltzer, M.D. (U California - Irvine)
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8:30 Welcome Sessions 3 and 4 Goals - Phil Landrigan View Presentation(546KB)
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Session 3: Metabolic Disorders Session Chair: Phil Landrigan
9:00-9:30 Epidemiology Elizabeth Hatch, Ph.D. (Boston U) View Presentation(1MB)
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9:30-10:00 Putative Mechanisms Amanda Drake, M.D. (University of Edinburgh) View Presentation(435KB)
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10:00-10:30 Clinical Medicine Robert Lustig, M.D. (U California-San Francisco) View Presentation(2MB)
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10:30-10:45 Break  
10:45-12:15 Discussion Christoph Vogel, Ph.D. (U California-Davis)
Maida P. Galvez, M.D. (Mount Sinai) View Presentation(367KB)
Pete Myers, Ph.D. (Environmental Health Sciences) View Presentation(367KB)
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12:15-1:15 Lunch  
Session 4: Attention Deficit Hyperactivity Disorder (ADHD) Session Chair: Cindy Lawler, Ph.D. (NIEHS)
1:15-1:45 Epidemiology Andrew Rowland, Ph.D. (U of New Mexico) View Presentation(1MB)
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1:45-2:15 Putative Mechanisms Jason Richardson, Ph.D. (U Medicine and Dentistry of New Jersey) View Presentation(686KB)
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2:15-2:45 Clinical Medicine Stephen Faraone, Ph.D. (SUNY Upstate Medical University) View Presentation(1MB)
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2:45-3:15 Break  
3:15-5:15 Discussion and Closing Comments Marjo-Riitta Jarvelin, M.D., Ph.D. (Imperial College London)
Susan Korrick, M.D. (Harvard)
Theodore Slotkin, Ph.D. (Duke)  View Presentation(41KB)
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5:15 Adjourn  

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