Developing New Chemicals Free of Endocrine Disruptors
Karen P. O’Brien, Ph.D.
Advancing Green Chemistry
NIEHS Grant R13ES016981
NIEHS grantees and scientists are part of a group of scientists proposing a new Tiered Protocol for Endocrine Disruption (TiPED) for detecting chemicals with possible endocrine disrupting properties. The voluntary protocol could help manufacturers and chemists avoid introducing endocrine disrupting chemicals during product and chemical development.
Endocrine disruptors are found in many consumer products and can led to developmental, reproductive, neurological, and immune problems. TiPED’s five testing tiers range from broad evaluation based on computer modeling to specific assays based on cells and whole organisms. The tiers progress in complexity and cost as well as the reliability of results. A user can use all the tiers or start with any tier in the system.
In a proof-of-principle test, the researchers used TiPED to analyze six endocrine disrupting chemicals, each with different endocrinological mechanisms. Each chemical was identified as endocrine active by one or more tiers. The scientists also established a plan to incorporate new assays into the protocol as scientific understanding of endocrine disruption continues to advance.
Citation: Schug TT, Abagyan R, Blumberg B, Collins TJ, Crews D, DeFur PL, Dickerson SM, Edwards TM, Gore AC, Guillette LJ, Hayes T, Heindel JJ, Moores A, Patisaul HB, Tal TL, Thayer KA, Vandenberg LN, Warner JC, Watson CS, vom Saal FS, Zoeller RT, O'Brien KP, Myers JP. 2013. Designing endocrine disruption out of the next generation of chemicals. Green Chem 15 (1):181-198.
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