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Genetic Link Determined for Prostate Cancer in African-American Men

Yuko Yamamura, Ph.D., M.D.
Anderson Cancer Center and Benjamin A. Rybicki, Ph.D., Henry Ford Health System
NIEHS Grants P30ES007784 and ES011126

Scientists have found a single nucleotide polymorphism that occurs in about five per cent of African-American men making them at greater risk for developing prostate cancer. This research was supported by NIEHS and the National Cancer Institute.

The study examined about one million single nucleotide polymorphisms across the genomes of 3,425 African-American men with prostate cancer and 3,290 African-American controls. The study is part of the Multiethnic Cohort study being conducted in a collaborative effort between the Keck School and the University of Hawaii.

In general, men of African descent are more susceptible to prostate cancer than others. The current study reports the discovery of a prostate cancer marker on chromosome 17 and builds on a previous finding by the same research team which elucidated a marker on chromosome 8. These studies support the need for additional genome-wide association studies to locate markers which may play a role in understanding racial and ethnic health disparities.

Citation: WHaiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, Cooney KA, Xu J, Kibel AS, Hu JJ, John EM, Gueye SM, Watya S, Signorello LB, Hayes RB, Wang Z, Yeboah E, Tettey Y, Cai Q, Kolb S, Ostrander EA, Zeigler-Johnson C, Yamamura Y, Neslund-Dudas C, Haslag-Minoff J, Wu W, Thomas V, Allen GO, Murphy A, Chang BL, Zheng SL, Leske MC, Wu SY, Ray AM, Hennis AJ, Thun MJ, Carpten J, Casey G, Carter EN, Duarte ER, Xia LY, Sheng X, Wan P, Pooler LC, Cheng I, Monroe KR, Schumacher F, Le Marchand L, Kolonel LN, Chanock SJ, Berg DV, Stram DO, Henderson BE. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet. 2011 Jun;43(6):570-3.

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