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Phage display of ScFv peptides recognizing the thymidine(6-4)thymidine photoproduct

PI: John Groopman
Johns Hopkins University

Background: Ultraviolet (UV) radiation from the sun produces DNA products in skin cells and is thus the major cause of skin cancer. To understand human susceptibility to skin cancer and to develop preventative measures sensitive assays need to be developed to detect and quantify DNA adduct formation in human skin. This group of investigators has made great strides in developing one such assay which may lead to improved predictability of susceptible individuals and early diagnosis of UV radiation-induced skin cancer.

Citation: A.G. Zavala, T. Lancaster, J.D. Groopman; P.T. Strickland, and S. Chandrasegaran. Nucleic Acids Research, 28(7): E24.
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Last Reviewed: 15 May 2007