Dr. Sharon Krueger
Program Director: David Williams
Project: Environmental PAH Mixtures as Skin and Transplacental Carcinogens
As part of the American Recovery and Reinvestment Act (ARRA), the Superfund Research Program (SRP) supplement provided funding for a research supplement to Oregon State University to improve the diversity of its research workforce.
Dr. Sharon Krueger is focusing on the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs) in two cancer models. PAH samples include air samples collected in Beijing prior to the Olympics and pure PAH compounds. A transplacental model of carcinogenesis is being used in addition to a two-stage model of skin cancer. In the transplacental model, offspring of mice exposed to these compounds during late gestation suffer significant mortality from a severe T-cell lymphoma while survivors develop lung tumors. Dr. Krueger will investigate molecular signatures of PAH exposure in these models employing microarray methods and analysis of epigenetic changes in gene expression.
Dr. Krueger is receiving training in epigenetics, PAH metabolites, DNA adducts and protein profiling. As part of life in the SRP program, she has many opportunities to find mentors and advisors. This supplement is providing Dr. Krueger with training in exciting new fields of science that will put her in high demand and give her the career guidance on how to best employ those new skills.
"From the moment I was diagnosed with Pompe disease as a graduate student, I have been reinventing and adapting my career. Pompe is a metabolic deficiency that leads to a rare relentlessly progressive muscular dystrophy causing loss of muscle strength and life in a wheelchair. I choose to follow a non-traditional career path, accepting positions that would enable me to acquire laboratory skills in molecular genetics, and would allow me to shift my focus to new interests in human metabolism and human health." Dr. Sharon Krueger, recipient of ARRA research supplement for underrepresented minorities.