Internal Dose of Environmental Agents
Technologies for Generating Precise Measures of Internal Dose of Environmental Agents
NIEHS supports the development of technologies and devices to generate precise measurements of internal dose of individual environmental agents and or their metabolites in real time and over time. It would be especially valuable to analyze multiple agents within a single class or multiple agents across more than one class. The development of a modular design allowing measurement of specific classes of chemical exposures for application in epidemiological studies (e.g., pesticides, endocrine-active chemicals, toxic metals, or components of indoor air pollution) is preferred.
Approaches that combine detection of individual analytes together with functional assays, e.g., measures of total estrogenicity or genotoxicity, are also encouraged.
- Development of sensors for measuring the levels of toxicants in biospecimens easily obtained from an individual, such as finger prick of blood, buccal cells, hair, exhaled breath, meconium, or urine.
- The development of integrated devices linking exposure at the point of contact, internal dose, and biological response.
The NIEHS contact person is:
Daniel Shaughnessy, Ph.D. (http://www.niehs.nih.gov/research/supported/dert/sphb/staff/shaughnessy/index.cfm)
Health Scientist Administrator
Tel (919) 541-2506
Fax (919) 316-4606