Biomedical Health Research
One goal of the SRP is to integrate both biomedical and non-biomedical research components to address the complex nature of hazardous waste management and remediation. The stories below are examples of biomedical research conducted by SRP researchers.
Basic metabolism studies lead to a treatment for laminitis in horses (http://www.niehs.nih.gov/news/newsletter/2013/1/science-basic/index.htm) : A compound developed by researchers at University of California (UC), Davis Superfund Research Program (SRP) to study basic catalytic mechanisms of an enzyme in the body is being used to treat laminitis in horses, relieving pain and inflammation.
Children Exposed to Cadmium May Be at Higher Risk for Learning Disabilities (http://www.niehs.nih.gov/news/newsletter/2012/3/science-cadmium/index.htm): Robert Wright, M.D., led a team of researchers to discover that children and teens with higher levels of cadmium in their bodies are more likely to have learning disabilities and be placed in special education.
Commonly Manufactured Nanomaterial Induces Neurovascular Toxicity (http://tools.niehs.nih.gov/srp/researchbriefs/view.cfm?Brief_ID=220) : Nanoalumina, a widely manufactured nanomaterial, can accumulate in brain cells, inducing nerve and blood vessel damage and protein degradation in the brain, according to a 2012 study from the University of Kentucky Superfund Research Program (UK SRP).
Novel Method Identifies Potential Key Pathway in Arsenic-Induced Birth Defects (http://tools.niehs.nih.gov/srp/researchbriefs/view.cfm?Brief_ID=221): Blocking the glucocorticoid receptor (GR) pathway in a chick embryo model prevents structural birth defects induced by arsenic, according to a 2013 study at the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP).
Prenatal Exposure to Perchloroethylene (PCE) and the Incidence of Birth Defects : Prenatal exposure to a chemical solvent can put babies at an increased risk for birth defects, according to a study published in the September 2009 issue of Environmental Health.
Residential Exposure to PCBs and Pesticides May Increase the Risk of Leukemia : The incidence of childhood leukemia in industrialized countries rose significantly from 1975 through 2004, and the reasons for the increase are not understood. Drs. Patricia Buffler and Catherine Metayer from the University of California at Berkeley are investigating how exposure to Superfund chemicals may affect a child's risk of contracting leukemia.
Study Links Prenatal Mercury Exposure and Fish Intake to ADHD-Related Behavior (http://tools.niehs.nih.gov/srp/researchbriefs/view.cfm?Brief_ID=215) : A Harvard University study suggests that low-level prenatal mercury exposure is associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD)-related behaviors.
Study Suggests Possible Therapy for Arsenic Toxicity (http://www.niehs.nih.gov/news/newsletter/2012/4/science-arsenic/index.htm): Columbia University researchers conduce one of the first large-scale genomic studies conducted in a developing country. Their findings suggest a possible route for preventing disease in people exposed to arsenic.
Superfund study examines carcinogenicity of nickel nanoparticles (http://www.niehs.nih.gov/news/newsletter/2011/october/science-superfund/index.cfm): Brown University researcher Agnes Kane, M.D., Ph.D., shows evidence that nickel nanoparticles activate a cellular pathway that contributes to cancer in human lung cells.
Widely Used Antibacterial Agents May Lead to Significant Health Concerns (http://tools.niehs.nih.gov/srp/researchbriefs/view.cfm?Brief_ID=213) : Triclosan (TCS), a chemical widely used for its antibacterial properties, was shown to weaken heart and skeletal muscle activity in animal models in a study performed at the University of California, Davis (UC Davis) Superfund Research Program (SRP) Center.