University of Illinois, Urbana-Champaign
Novel Methods to Assess the Effects of Chemicals on Child Development
Child Health Specialist: Susan Korrick, M.D.
Developmental and reproductive effects of environmental contaminants
Bisphenol A (BPA), phthalates, high-fat diet (HFD)
Primary Health Outcomes
Neurological and reproductive development, oxidative stress
The Children's Environmental Health and Disease Prevention Research Center uses a multidisciplinary approach to address critical gaps in our knowledge about how exposure to endocrine disrupting chemicals affects child development. Researchers are examining a group of pregnant women and their babies being followed in Urbana, Ill. (I-KIDS Cohort), as well as adolescents from New Bedford, Mass. (NBC cohort).
Phthalates and bisphenol A (BPA) are endocrine disrupting chemicals found in many consumer products. Center researchers are using animal models and human studies to investigate the effects of these chemicals, alone and combination with a high fat diet, on reproductive and neural development during the critical prenatal and adolescent development periods. The researchers will also assess cellular and molecular mechanisms that might be involved in health effects stemming from endocrine disruptor exposures and diet.
Project leader: Susan Korrick, M.D.
This study is investigating the effects of phthalates and BPA, both alone and combination with a high fat diet, on physical and neurodevelopment. Researchers are examining a group of pregnant women and their babies as well as a group of adolescents.
Project leader: Jodi A. Flaws, Ph.D.
Using mouse models that allow the study of the timing of the exposures assessed in the two population studies (project 1), researchers are exploring mechanisms by which endocrine disrupters and a high fat diet adversely affect reproductive health. Findings from this work could lead to the development of new targets for the treatment of chemical/diet-induced reproductive problems.
Project leader: Janice M. Juraska, Ph.D.
This study is examining how endocrine disruptors and diet affect the normal development of the nervous system by using mouse models to examine the timing of the exposures assessed in the two population studies (project 1). The research is specifically exploring cellular and molecular mechanisms and will also identify neurological outcomes that can be assessed in longitudinal follow-ups of the population studies.
Core Leader: Barbara H. Fiese
The Illinois Community Outreach and Translation Core (COTC) serves as the organizing hub of information and emerging knowledge about the effects that chemical exposure and high fat diets can have on developing children and adolescents. It links center investigators with community stakeholders including pediatricians, public health professionals, parenting groups, and policy makers.