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Your Environment. Your Health.

University of California, Berkeley

Center for Integrative Research on Childhood Leukemia and the Environment


University of California, Berkeley
Catherine Metayer, M.D., Ph.D.
cmetayer@berkeley.edu

Project Description:

In remembrance of Patricia Buffler, Ph.D., the esteemed former center director, please see this article on the UC Berkeley website.

Website
Publications

Environmental Exposures

Pesticides, tobacco-related contaminants, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs)

Primary Health Outcomes

Childhood leukemia

Scientists at the Center for Integrative Research on Childhood Leukemia and the Environment study how exposure to contaminants in the womb and early in life might contribute to leukemia in children. Research focuses on pesticides, tobacco-related contaminants, polychlorinated biphenyls (PCBs), and brominated flame-retardants. The scientists identify chemicals that might increase risk for leukemia and look at how these chemicals interact with genes involved in leukemia.

Center researchers evaluate early environmental exposures using home dust samples and biospecimens from the Northern California Childhood Leukemia Study. They established a network of eight clinical institutions through which they identify and enroll newly diagnosed cases of childhood leukemia.


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Project 1: Childhood Leukemia International Consortium studies

Project leader: Catherine Metayer, Ph.D., M.D.

cmetayer@berkeley.edu

Multiple chemical exposures can interact to dramatically affect the health of children. Using data from 14 case-control studies in 10 countries within the Childhood Leukemia International Consortium, this project is assessing how environmental chemicals contribute to childhood leukemia. The researchers examine links between parental smoking and home pesticide use. They also study genetic variations that affect a child’s ability to process foreign chemicals and the risks for different types of childhood leukemia in different groups of people.


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Project 2: Exposure assessment for childhood leukemia

Project leader: Stephen M. Rappaport, Ph.D.

srappaport@berkeley.edu

This project is improving assessment of whether, and when, children have experienced exposure to environmental contaminants. The study builds on data from the Northern California Childhood Leukemia Study by looking at levels of nicotine, polycyclic aromatic hydrocarbons from combustion, PCBs, and brominated flame-retardants in the blood and in house dust. The investigators use methods newly developed at the University of California, Berkeley, to analyze chemical exposures using dried blood spots collected at birth.


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Project 3: Prenatal exposures, DNA methylation, and childhood leukemia

Project leader: Joseph L. Wiemels, Ph.D.

joe.wiemels@ucsf.edu

This project uses newborn dried blood spots from the general population to examine how certain contaminants affect a person’s cells at the molecular level. Understanding how contaminants can change a person’s genetic code and gene expression can help advance methods for early detection of leukemia.


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Community Outreach and Translation Core

Core Leader: Amy D. Kyle, Ph.D.

adkyle@berkeley.edu

The Community Outreach and Translation Core (COTC) is developing a narrative that communicates key questions, findings, and trajectory for future research, to find the causes and cures for leukemia in children. The COTC also engages with parents, health and medical care professionals, childcare professionals, educators, community leaders, policy makers, and advocates interested in children's environmental health to develop relevant messages and materials about childhood leukemia and the opportunities for research in this field, and to distribute them to key audiences.


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