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Your Environment. Your Health.

Biological Response Indicators

Exposure Biology Program

The Biological Response Indicators program has improved upon traditional approaches that characterized exposures by quantifying the intake, contact, or internal dose of agents using questionnaires or body burden estimates based on environmental monitors.  These methods have many known limitations: misclassification error, individual variability, temporal uncertainty, and temporal relevance to the natural history of disease. These limitations in exposure assessment methodologies have produced conflicting data and hampered our ability to prevent, predict, and treat disease. The two initiatives within the Biological Response Indicators program have supported the development and the verification of biomarkers and biosensors that reflect alterations in key physiological pathways after exposure to environmental stressors. These programs adopt a product-driven approach to the development, confirmation, and application of innovative biosensors and panels of biomarkers, especially those with potential for scale-up for use in large population studies.

Grantees

Project TitlePrincipal InvestigatorInstitution
Center for Novel Biomarkers of ResponseJoel G. PoundsBattelle Pacific Northwest Laboratories
A non-invasive gene-expression biomarker of airway response to tobacco exposureAvrum E. SpiraBoston University Medical Campus
Macronutrients, Mitochondria and Blood Metabolome/Proteome Disease Risk ProfilesBruce S. KristalBrigham And Women's Hospital
Genomic and Metabolomic Responses to Alcohol-induced Liver DamageAlbert J. FornaceGeorgetown University
Early Disease Biomarkers of PCB-exposed Human PopulationSisir K. DuttaHoward University
Comet-Chip: A High-Throughput DNA Damage Sensor for Enviornmental Health StudiesBevin P. EngelwardMassachusetts Institute of Technology
Environmental Epigenetics and Stem/Progenitor Cell InjuryTim H.M. HuangOhio State University
Genomic and Proteomic Biomarkers of Biological Responses to ExposureCoral LamartiniereUniversity of Alabama at Birmingham
Biological Response Indicators of Environment Stress CentersStephen Morris RappaportUniversity of California at Berkeley
Biomarkers of Organophosphate-Adducted ProteinsCharles Mark ThompsonUniversity of Montana
Exposure and biological response biomarkers of cigarette smokeIan Alexander BlairUniversity of Pennsylvania
Biomarker signatures of biological, chemical, or psychological stressDavid A. LawrenceWadsworth Center

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