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Your Environment. Your Health.

Genome Integrity & Environmental Stress Grantees

Susceptibility & Population Health Branch

Name Institution Lead Scientist
Role of DNA Polymerase eta in Error-free Bypass of DNA Lesions & Cancer Prevention Mount Sinai School of Medicine Aneel Aggarwal
Role of Human DNA Polymerase iota in Replicative Bypass of DNA lesions Mount Sinai School of Medicine Aneel Aggarwal
Mechanisms of Environmental and Nuclear and Mitochondrial Mutagenesis Fred Hutchinson Cancer Research Center Jason Bielas
Linkage of Lung Inflammation to 8-oxoguanine and OGG1 University of Texas Medical Branch at Galveston Istvan Boldogh
High Throughput Technology for Assessing Global DSB Repair Capacity Columbia University Health Sciences David Brenner
Regulation of the DNA damage Response Stanford University Karlene Cimprich
Novel Interactions of DNA Repair Processes in Replication Fork Maintenance University of California-Lawrence Berkeley Lab Priscilla Cooper
Mechanisms of DNA Replication and Repair Vanderbilt University David Cortez
R15 AREA: Replication in the Presence of Oxidative DNA damage Portland State University Justin Courcelle
Inflammation as a Mediator of Dynamic DNA Mutations Brown University Sarah Delaney
Molecular Mechanisms of Nitroarene Toxicity State University New York Stony Brook Carlos de los Santos
Cellular Responses to Oxidative Stress in Models of Colon Cancer Development Emory University Paul Doetsch
CometChip: Enabling Translation of DNA Damage and Repair Assays Massachusetts Institute of Technology Bevin Engelward
Cross-Links at Abasic Sites in Duplex DNA University of Missouri-Columbia Kent Gates
Hypoxia, Genetic Instability and DNA Mismatch Repair Yale University Peter Glazer
SWI/SNF Chromatin Remodeling in Nucleotide Excision Repair University of Miami School of Medicine Feng Gong
Biochemical Basis of SOS-Induced Mutagenesis University of Southern California Myron Goodman
Nucleoprotein Structures Formed at Sites of DNA Damage University of North Carolina Chapel Hill Jack Griffith
Polymerase Interactions with Carcinogen-Modified DNA Vanderbilt University F. Peter Guengerich
Oxidative DNA Damage Processing; Role in Human Pathology and Aging Stanford University Philip Hanawalt
Cytoplasmic Damage and Genotoxicity Columbia University Health Sciences Tom Hei
Suppressors of Eukaryotic Mutator Phenotypes University of Washington Alan Herr
Repair of Inflammation-Induced DNA damage University of Texas, Austin Seongmin Lee
The Role of Human DNA Polymerase eta in the Mutagenic Response to Oxidative Stress North Carolina State University, Raleigh Scott McCulloch
Mechanism of Mammalian Trans-lesion DNA Synthesis State University New York Stony Brook Masaaki Moriya
Mechanisms of Telomeric DNA Loss and Repair University of Pittsburgh Patricia Opresko
UV Damage, Repair, and Mutagenesis City of Hope/Beckman Research Institute Gerd Pfeifer
Role of Rev1 in Error-Free Replication of DNA Damage and in Mutation Prevention University of Texas Medical Branch at Galveston Satya Prakash
Roles of Human DNA Polymearse Epsilon in Mutagenesis and Genome Stability Tulane University of Louisiana Zachary Pursell
Synthesis, Structure and Replication of Carcinogen-Modified Oligonucleotides Vanderbilt University Carmelo Rizzo
Developing Novel Methods to Measure DNA Repair Capacity in Human Populations Massachusetts Institute of Technology Leona Samson
Oxidative Pathways of Guanine in DNA New York University Vladimir Shafirovich
Effects of Environmental Contamination on Gene Copy Number Variation: Molecular B Indiana University Bloomington Joseph Shaw
Translesion Synthesis DNA Polymerases and Genome Instability University of Nebraska Medical Center Polina Shcherbakova
Genetic Defects in a Novel Radiation Sensitive Syndrome Rutgers Cancer Institute of New Jersey Zhiyuan Shen
DNA Repair In A Hormone Responsive Gene Washington State University Michael Smerdon
Repair of Carcinogen Damaged DNA in Human Chromatin Washington State University Michael Smerdon
DNA Repair Genes and Proteins of the RAD52 Group Yale University Patrick Sung
Homology-directed Chromosome Damage Repair via the BRCA2-PALB2 Axis Yale University Patrick Sung
DNA Polymerase Beta Variants and Cancer Yale University Joann Sweasy
DNA Damage Recognition by Nucleotide Excision Repair Proteins University of Pittsburgh Bennett Van Houten
Mechanism of Eukaryotic Environmental Mutagenesis Massachusetts Institute of Technology Graham Walker
DNA Damage Responses Following Genotoxin Exposure Ohio State University Altaf Wani
Cross-Talking Pre-incision Events of Eukaryotic NER Ohio State University Altaf Wani
High Throughput Assessment of De Novo CNV Formation in Eukaryotic Cells University of Michigan Thomas Wilson
Genotoxicity of Chromium Compounds Brown University Anatoly Zhitkovich

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