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Breast Cancer & the Environment Research Centers

Breast Cancer & the Environmental Research Centers: Cell
Table of Contents


  • Pons-Estel GJ, Alarcón GS, Scofield L, Reinlib L, Cooper GS. (2010). Understanding the epidemiology and progression of systemic lupus erythematosus. Seminars in arthritis and rheumatism 39(4):257-268. [Abstract]


  • Atkin C, Smith S, Ferguson V, McFeters C (2008). A Comprehensive Analysis of Breast Cancer News Coverage in Leading Media Outlets. J of Health Communication 13:3-17. DOI: 10.1080/10810730701806912
  • Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MJ, Werb Z (2008). Visualizing Stromal Cell Dynamics in Different Tumor Microenvironments by Spinning Disk Confocal Microscopy. Disease Models & Mechanisms 1:155-167. DOI: 10.1242/dmm.000596
  • Ewald AJ, Brenot A, Duong M, Chan B, Werb Z (2008). Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis. Developmental Cell 14:570-58. DOI: 10.1016/j.devcel.2008.03.003
  • Kariagina A, Aupperlee M, Haslam S (2008). Progesterone Receptor Isoform Functions in Normal Breast Development and Breast Cancer. Crit Rev in Eucaryotic Gene Ex 18: 11-33.
  • Kouros-Mehr H, Bechis S, Slorach E, Littlepage L, Egeblad M, Ewald A, Pai S, Ho I, Werb Z (2008). GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model. Cancer Cell 13(2):141-152. DOI: 10.1016/j.ccr.2008.01.011 PMID:18242514
  • Kouros-Mehr H, Kim J, Bechis S, Werb Z (2008). GATA-3 and the Regulation of the Mammary Luminal Cell Fate. Curr Opin Cell Biol 20(2):164-170. DOI: 10.1016/ PMID:18358709
  • Lu P, Ewald AJ, Martin GR, Werb Z (2008). Genetic Mosaic Analysis Reveals FGF Receptor 2 Function in Terminal End Buds During Mammary Gland Branching Morphogenesis. Developmental Biology 321:77–87. DOI: 10.1016/j.ydbio.2008.06.005
  • Moral R, Wang R, Russo I, Lamartiniere C, Pereira J, Russo J (2008). Effect of Prenatal Exposure to the Endocrine Disruptor Bisphenol A on Mammary Gland Morphology and Gene Expression Signature. J of Endocrinology 196:101-112.
  • Santos SJ, Haslam S, Conrad S (2008). Estrogen and Progesterone are Critical Regulators of Stat5a Expression in the Mouse Mammary Gland. Endocrinology 149:329-338. DOI: 10.1210/en/2007-0594
  • Teitelbaum SL, Britton J, Calafat A, Ye X, Silva M, Reidy J, Galvez M, Brenner B, Wolff M (2008). Temporal Variability in Urinary Concentrations of Phthalate Metabolites, Phytoestrogens and Phenols Among Minority Children in the United States. Environmental Research 106:257-269.
  • Welm BE, Dijkgraaf J, Bledau A, Welm A, Werb Z (2008). Lentiviral Transduction of Mammary Stem Cells for Analysis of Gene Function During Development and Cancer. Cell Stem Cell 2:90-102. PMID:18371425
  • Wetmur JG, Chen J (2008). An Emulsion of PCR-based Method for Molecular Haplotyping. In Environmental Genomics (Methods in Molecular Biology, vol 410) Martin, C., ed., Humana Press, Totowa, NJ.
  • Whitten P, Smith S, Munday S, LaPlante S (2008). Communication Assessment of the Most Frequented Breast Cancer Websites: Evaluation of Design and Theoretical Criteria. Journal of Computer Mediated Communication, 13, 880-911. DOI: 10.1111/j.1083-6101.2008.00423.x


  • Aupperlee MD, Haslam S (2007). Differential hormonal regulation and function of PR isoforms in normal adult mouse mammary gland. Endocrinology 148(5):2290-2300. DOI: 10.1210/en/2006-1721 ( )
  • Brenner BL, Galvez M (2007). Community interventions to reduce exposure to chemicals with endocrine disrupting properties. In Endocrine-disrupting Chemicals: From Basic Research to Clinical Practice ed. Andrea C. Gore. Humana Press.
  • Claudio L (2007). Centered on breast cancer. Env Hlth Perspective 115(3):A132-133.
  • Fata JE, Mori H, Ewald A, Zhang H, Yao E, Werb Z, Bissell M (2007). The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGFa and FGF7 in morphogenesis of mouse mammary epithelium. Dev. Biol. 309(1):193-207. PMID:17448457
  • Fernandez-Gonzalez R, Illa-Bochaca I, Ortiz de Solorzano C, Barcellos-Hoff M (2007). In situ analysis of mammary progenitors. In Protocols for Stem Cells IM Conboy and M Conboy, editors. Humana Press, Totowa , NJ.
  • Fernandez-Gonzalez R, Munoz-Barrutia A, Barcellos-Hoff M, Ortiz de Solorzano C (2007). Quantitative in vivo microscopy: the return from the 'omics'. Curr Opin Biotechnol Oct 17(5):501-510. PMID:16899361
  • Gear R, Yan M, Schneider J, Succoop P, Heffelfinger S, Clegg D (2007). Charles River Sprague Dawley rats lack early age-dependent succeptibility to DMBA-induced mammary carcinogenesis. Int J Biol Sci 3(7):408-416. ( )
  • Jenkins S, Rowell C, Wang J, Lamartiniere C (2007). Prenatal TCDD exposure predisposes for mammary cancer in rats. Reproductive Toxicology 23:391-396. DOI: 10.1016/j.reprotox.2006.10.004
  • Kariagina A, Aupperlee M, Haslam S (2007). Progesterone receptor isoforms and proliferation in the rat mammary gland during development. Endocrinology 148(6):2723-2736. DOI: 10.1210/en.2006-1493
  • Moral R, Wang R, Russo I, Mailo D, Balogh G, Lamartiniere C, Russo J (2007). The plasticizer butyl benzyl phthalate induces genomic changes inn rat mammary gland after neonatal/prepubertal exposure. BMC Genomics 8:453.
  • Oketch-Rabah HA, Barcellos-Hoff M (2007). Stroma, microenvironment and radiation carcinogenesis. Reviews Cancer Biology & Therapeutics VNUN Kasid, A Haimovitz-Friedman & M Bar-Eli, editor. Transworld Research Network, Kerala, India.
  • Page-McCaw A, Ewald A, Werb Z (2007). Matrix metalloproteinases and the regulation of tissue remodeling. Nat. Rev. Mol. Cell Biol. 8:221-233. PMID:17318226
  • Wolff MS, Teitelbaum S, Windham G, Pinney S, Britton J, Chelimo C, Godbold J, Biro F, Kushi L, Pfeiffer C, Calafat A (2007). Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Env Hlth Perspective 115(1):116-21. DOI: 10.1289/ehp.9488


  • Atkin, C.K., Smith, S.W., Ferguson , V. & McFeters, C. A comprehensive Analysis of Breast Cancer, New Coverage in Leading Media Outlets. Journal of Health Communication (In Press).
  • Aupperlee MD, Kariagina A, Osuch J, Haslam S (2006). Progestins and breast cancer. Breast Disease 24:38-58.
  • Biro FM, Khoury P, Morrison J (2006). Influence of obesity on timing of puberty. Int J Androl 29:272-277. DOI: 10.1111/j.1365-2605.2005.00602.x
  • Claudio L (2006). Making progress on breast cancer. Env Hlth Perspective 114(2):A98-99.
  • Claudio L (2006). RTP leaders unite to advance environmental health. Env Hlth Perspective 114(9):A524-525.
  • Clegg DJ, Heffelfinger S (2006). Obesity: its influence on breast cancer susceptibility. Women's Health 2:1-9.
  • Fleisch MC, Maxwell C, Barcellos-Hoff M (2006). The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs. Endocr Rel Cancer 13:379-400. ( PDF Summary )
  • Glass RI , Bridbord K, Rosenthal J, Claudio L (2006). Global perspective on environmental health. Env Hlth Perspective 114(8):A454-455.
  • Haslam SZ (2006). Experimental mouse model of hormonal therapy effects on the postmenopausal breast. Breast Disease 24:71-78.
  • Kouros-Mehr H, Slorach E, Sternlicht M, Werb Z (2006). GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127:1041-1055. DOI: 10.1016/j.cell.2006.09.048 PMID:17129787
  • Kouros-Mehr H, Werb Z (2006). Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn 235:3404-3412. PMID:17039550
  • Lu P, Sternlicht M, Werb Z (2006). Comparative mechanisms of branching morphogenesis in diverse systems. J Mamm. Gland Biol. Neoplasia 11:213-228. PMID:17120154
  • Lum DH, Tan J, Rosen S, Werb Z (2006). Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase, Sulf2. Mol. Cell. Biol. 27:678-688. PMID:17116694
  • Rollison DE , Helzlsouer K, Pinney S (2006). Personal hair dye use and cancer: A systematic literature review and evaluation of exposure assessment in studies published since 1992. J. of Tox. And Environ. Health 9(5):413-439.
  • Silk KJ, Bigsby E, Volkman J, Kingsley C, Atkin C, Ferrara M, Goins L (2006). Formative research on adolescent and adult perceptions of risk factors for breast cancer. Social Science and Medicine 63(12):3124-3136.
  • Sternlicht, M.D. (2006). Branching morphogenesis: the cues that regulate mammary ductal development. Breast Cancer Res. 8:201. DOI: 10.1186bcr1368 PMID: 16524451
  • Sternlicht MD (2006). Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis. Breast Cancer Res. 8:201. DOI: 10.1186/bcr1368 PMID:16524451
  • Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z (2006). Hormonal and local control of mammary branching morphogenesis. Differentiation 74:365-381. PMID:16916375
  • Wallenstein S, Chan W, Wetmur J (2006). Comparison of statistical models for analyzing genotype, inferred haplotype and molecular haplotype data. Molec. Genet. Metab. 89(3):270-273.
  • Wetmur, J.G., & Chen, J. An emulsion of PCR-based method for molecular haplotyping. Methods in Molecular Biology. Environmental Genomics, Martin C, ed, Humana Press, Totowa , NJ , 2006 (in press).
  • Wolff MS (2006). Endocrine disruptors: Challenges for environmental research in the 21st century. Annals NY Acad. Sci. 1076:228-38.


  • Atabai K, Fernandez-Gonzalez R, Huang X, Ueki A, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D (2005). Mfge8 is critical for mammary gland remodeling during involution. Mol. Biol. Cell. 16:5528-5537. PMID:16195353
  • Aupperlee MD, Smith K, Kariagina A, Haslam S (2005). Progesterone receptor isoforms A and B: Temporal and spatial differences in expression during murine mammary gland development. Endocrinology 146:3577-88. DOI: 10.1210/en.2005-0346
  • Barcellos-Hoff MH (2005). Integrative radiation carcinogenesis: Interactions between cell and tissue responses to DNA damage. Sem. Cancer Biol 15:138-147. PDF Summary (abstract)
  • Barcellos-Hoff MH, Medina D (2005). New highlights on stroma-epithelial interactions in breast cancer. Breast Cancer Res 7:33-36. PMID:15642180
  • Barcellos-Hoff MH, Park C, Wright E (2005). Radiation and the microenvironment: Tumorigenesis and therapy. Nat Cancer Rev 5:867-875. PMID:16327765 (PDF Summary)
  • Biro FM, Khoury P, and Morrison JA, Influence of Obesity on Timing of Puberty: Intl J of Andrology, 2005
  • Fernandez-Gonzalez R, Barcellos-Hoff M, Ortiz de Solorzano C (2005). A tool for the quantitative spatial analysis of complex cellular systems. IEEE Trans Image Process 14:1300-1313. PMID:16190466
  • Galvez MP, Forman J, Landrigan P (2005). Children's environmental health. In Environmental Health: From Local to Global Eds. Frumkin H.
  • Grimm SL, Contreras A, Barcellos-Hoff M, Rosen J (2005). Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in C/EBP beta-null mice. J Biol. Chem 280(43):36301-36309. PMID:16120603
  • Heissig B, Rafii S, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin D, Ogawa H, Werb Z, Hattori K (2005). Low-dose irradiation promotes tissue revascularization through Kit-ligand mediated release of VEGF from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp. Med. 202:739-750. PMID:16157686  PDF Summary
  • Hiatt RA (2005). The Breast Cancer and the Environment Research Centers. Essays on the future of environmental health research. Env Hlth Perspective 16-23. DOI: 10.1289/ehp.7987
  • Rodier F, Kim S, Nijjar T, Yaswen P, Campisi J (2005). Cancer and aging: The importance of telomeres in genome maintenance. Int. J Biochem Cell Biol 37: 977-990. PMID:15743672
  • Rowell C, Carpenter D, Lamartiniere C (2005). Chemoprevention of breast cancer, proteomic discovery of genistein action in the rat mammary gland. J Nutrition Sci 135:2953S-2959S.
  • Rowell C, Carpenter D, Lamartiniere C (2005). Modeling biological variability in 2-D gel proteomic carcinogenesis experiments. Journal of Proteome Research 4:1619-1627.
  • Sternlicht MD, Sunnarborg S, Kouros-Mehr H, Yu Y, Lee D, Werb Z (2005). Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development 132:3923-3933. PMID:16079154
  • Wetmur JG, Kumar M, Zhang L, Palomeque C, Wallenstein S, Chen J (2005). Molecular haplotyping by linking emulsion PCR: Analysis of PON1 haplotypes and phenotypes. Nucleic Acids Res 33:2615-2619.
  • Whitten P, Doolittle G, Mackert M (2005). Providers' acceptance of telehospice. J of Palliative Medicine 8(4):730-735.
  • Wolff MS, Britton J, Russo J (2005). TCDD and Puberty in Girls. Env Hlth Perspective 113:A17. (letter)


  • Cases S, Zhou P, Schillingford J, Wiseman B, Fish J, Hennighausen L, Werb Z, Farese Jr R (2004). Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development 131(13):3047-3055. PMID:15163627
  • Claudio L (2004). Translation: Breast Cancer Takes Center Stage. Env Hlth Perspective 112:A92-94. (article)
  • Heissig B, Rafii S, Rafael T, Ohsaka A, Ogawa H, Okumura K, Nakauchi H, Werb Z & Hattori K. Low-dose irradiation promotes angiogenesis through MMP-9 mediated mobilization of endothelial progenitors and Kit-ligand mediated release of VEGF from mast cells. 2004; J Exp. Med. 202:739-750. PMID: 16157686
  • Whitten P (2004). Evidence regarding patient and provider perceptions and health indicators for telehome health. Public Policy and Aging Report 14(1): 19-21.


  • Aupperlee MD, Kariagina A, Osuch J and Haslam SZ. Progestins and Breast Cancer. 2006 Breast Disease 24: 38-58.
  • Barcellos-Hoff, M.H., and Medina , D. (2005). New highlights on stroma-epithelial interactions in breast cancer. Breast Cancer Res 7, 33-36. PMID: 15642180
  • Barcellos-Hoff, M.H., Park, C.C., and Wright, E.G. (2005). Radiation and the microenvironment: Tumorigenesis and therapy. Nat Cancer Rev 5, 867-875. PMID: 16327765
  • Sandra Z. Haslam. Experimental Mouse Model of Hormonal Therapy Effects on the Postmenopausal Breast. 2006 Breast Disease 24:71-78
  • Lu, P., M.D. Sternlicht & Z. Werb (2006). Comparative mechanisms of branching morphogenesis in diverse systems. J. Mamm. Gland Biol. Neoplasia. In press.
  • Wolff, M.S., Endocrine disruptors: Challenges for Environmental Research in the 21st Century, Ann NY Acad Sci, in press.

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