Biological Response Indicators
Exposure Biology Program
The Biological Response Indicators program has improved upon traditional approaches that characterized exposures by quantifying the intake, contact, or internal dose of agents using questionnaires or body burden estimates based on environmental monitors. These methods have many known limitations: misclassification error, individual variability, temporal uncertainty, and temporal relevance to the natural history of disease. These limitations in exposure assessment methodologies have produced conflicting data and hampered our ability to prevent, predict, and treat disease. The two initiatives within the Biological Response Indicators program have supported the development and the verification of biomarkers and biosensors that reflect alterations in key physiological pathways after exposure to environmental stressors. These programs adopt a product-driven approach to the development, confirmation, and application of innovative biosensors and panels of biomarkers, especially those with potential for scale-up for use in large population studies.
Grantees
| Project Title | Principal Investigator | Institution |
|---|---|---|
| Center for Novel Biomarkers of Response | Joel G. Pounds | Battelle Pacific Northwest Laboratories |
| A non-invasive gene-expression biomarker of airway response to tobacco exposure | Avrum E. Spira | Boston University Medical Campus |
| Macronutrients, Mitochondria and Blood Metabolome/Proteome Disease Risk Profiles | Bruce S. Kristal | Brigham And Women's Hospital |
| Genomic and Metabolomic Responses to Alcohol-induced Liver Damage | Albert J. Fornace | Georgetown University |
| Early Disease Biomarkers of PCB-exposed Human Population | Sisir K. Dutta | Howard University |
| Comet-Chip: A High-Throughput DNA Damage Sensor for Enviornmental Health Studies | Bevin P. Engelward | Massachusetts Institute of Technology |
| Environmental Epigenetics and Stem/Progenitor Cell Injury | Tim H.M. Huang | Ohio State University |
| Genomic and Proteomic Biomarkers of Biological Responses to Exposure | Coral Lamartiniere | University of Alabama at Birmingham |
| Biological Response Indicators of Environment Stress Centers | Stephen Morris Rappaport | University of California at Berkeley |
| Biomarkers of Organophosphate-Adducted Proteins | Charles Mark Thompson | University of Montana |
| Exposure and biological response biomarkers of cigarette smoke | Ian Alexander Blair | University of Pennsylvania |
| Biomarker signatures of biological, chemical, or psychological stress | David A. Lawrence | Wadsworth Center |
