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Large eosinophilic hepatocytes (eosinophilic granular cytoplasm represents peroxisome proliferation), biliary hyperplasia (ducts, ductules, oval cells), several mitotic figures, and pigment are present in the liver of this mouse fed a diet containing di-(2-ethylhexyl)-phthalate (DEHP) for 10 months.

Oxidase immunohistochemical stain showing small oxidase-containing peroxisomes in smaller hepatocytes (on left) in a PPAR alpha null mouse given di(2-ethylhexyl)phthalate as compared with enlarged hepatocytes (on right) with peroxisome proliferation induced by DEHP in a wild type mouse.