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Necrotic, Inflammatory and Vascular Lesions of the Liver

The Digitized Atlas of Mouse Liver Lesions

Angiectasis - Click on thumbnails to view larger images
Angiectasis (peliosis hepatis, telangiectasis) is an incidental finding occasionally noted in aging mice. In extensive lesions, atrophy of adjacent hepatocytes may be seen. The lesions consists of dilated sinusoidal spaces lined by normal endothelial cells and filled with blood cells in immersion-fixed specimens. This lesion is occasionally associated with hepatocellular neoplasms. Angiectasis typically consists of smaller blood channels than is seen in hemangiomas. Also, angiectatic vascular channels are often not associated with endothelial cell proliferation as is seen in hemangiomas.

These examples represent low magnification views of angiectasis.

angiectasis low magnification

angiectasis low magnification

 
These examples represent medium magnification views of angiectasis.
angiectasis low magnification

angiectasis low magnification

 
These examples represent high magnification views of angiectasis.
angiectasis low magnification

angiectasis low magnification

angiectasis low magnification

angiectasis low magnification

  
Apoptosis - Click on thumbnails to view larger images
Apoptosis is a form of necrosis and is sometimes referred to as single cell necrosis. Apoptotic cells and apoptotic bodies in the liver are classically characterized by a rounding up of dying hepatocytes that often have hypereosinophilic cytoplasm and are surrounded by a clear halo resulting from fragmentation and contraction of the dying hepatocyte. Prior to development of rounded apoptotic cells and bodies, affected cells are hypereosinophilic, but may be more angular without a surrounding clear halo. Apoptotic bodies often contain fragments of dense nuclear material, which is hyperbasophilic, although some apoptotic bodies may consist of only condensed cytoplasm. Up to three adjacent apoptotic bodies are generally considered to originate from a single dying hepatocyte. Apoptotic bodies may be free or contained within Kupffer cells or normal hepatocytes.
Early development of apoptosis. Affected hepatocytes are hypereosinophilic and angular with fragmented and condensed nuclear material within the cytoplasm.
angiectasis low magnification

angiectasis low magnification

 
Apoptotic bodies (arrows) as well as polyploid hepatocytes are present. Polyploid hepatocytes containing either single large nuclei or multiple nuclei are also evident.
Bile duct cyst

Bile duct cyst

 
In situ end labeled of an apoptotic cell. Terminal desoxyribosyl-transferase mediated dUTP end labeling stain.
angiectasis low magnification

angiectasis low magnification

 
Helicobacter Hepaticus- Click on thumbnails to view larger images
Chronic active inflammation associated with an increased incidence of hepatocellular neoplasia has been described in mice with Helicobacter hepaticus infection. The hepatitis starts as a focal, non-suppurative inflammation and progresses to chronic active hepatitis with minimal evidence of hepatocellular necrosis. Hepatocytomegaly, oval cell hyperplasia, cholangitis, bile duct hyperplasia, and cellular pleomorphism are characteristic changes associated with this infection. Helical bacterial organisms can sometimes be demonstrated with the Warthin-Starry silver stain.

Diffuse proliferation of sinusoidal lining cells, hepatocytomegaly, and karyomegaly are evident in this liver.

Bile duct cyst

Bile duct cyst

 
Chronic active hepatitis with oval cell hyperplasia and hepatocytomegaly are characteristic of infection with Helicobacter hepaticus. In the trichrome stain, note pericellular fibrosis (right) versus the control (left).
Bile duct cyst

Bile duct cyst

 
In situ end labeled of an apoptotic cell. Terminal desoxyribosyl-transferase mediated dUTP end labeling stain.
angiectasis low magnification

angiectasis low magnification

 
Inflammation and Necrosis- Click on thumbnails to view larger images
Coagulation necrosis is characterized by distinct eosinophilic cytoplasm with pyknotic or absent nuclei. Infarction of hepatic lobes is a form of coagulation necrosis.

Focal coagulation necrosis.

fatty change in liver

fatty change in liver

 
Another example of focal necrosis.
example of focal necrosis

example of focal necrosis

 
Extensive necrosis of a liver lobe may occur secondary to torsion.
large areas of fatty change liver

large areas of fatty change liver

 
The left image shows a focus of necrosis with an early inflammation cell infiltration at the periphery of the necrotic hepatocytes. In the right image, the inflammatory reaction is more pronounced.
a focus of necrosis with an early inflammation cell infiltration at the periphery of the necrotic hepatocytes

necrosis with a more pronounced inflammation cell infiltration at the periphery of the necrotic hepatocytes

 
This is an example of centrilobular hepatocellular necrosis with associated hemorrhage sometimes referred to as hemorrhagic necrosis.
an example of centrilobular hepatocellular necrosis with associated hemorrhage sometimes referred to as hemorrhagic necrosis


 
an example of centrilobular hepatocellular necrosis with associated hemorrhage sometimes referred to as hemorrhagic necrosis


 
 
Marked centrilobular necrosis in a B6C3F1 male mouse chronically fed acetaminophen. Note depression of liver surface due to hepatocyte loss and pigment deposition. Areas of hemorrhage are often associated with the necrosis.
large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

In addition to hepatic necrosis, inflammation, and pigment deposition, there is a venous thrombus present in this mouse treated with acetaminophen.
large areas of fatty change liver

  
Necrosis and hemorrhage are present in this mouse treated with acetaminophen.
large areas of fatty change liver

  
Mild centrilobular necrosis is evident following treatment with acetaminophen.
large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

Another example of mild centrilobular necrosis induced by acetaminophen treatment. Note nuclear and cytoplasmic changes in hepatocytes surrounding the central vein.
large areas of fatty change liver

  
Microgranulomas consisting of mononuclear inflammatory cells and associated with hepatocyte necrosis are commonly seen in mouse liver.
large areas of fatty change liver

large areas of fatty change liver

 
Granuloma in the liver of a B6C3F1 mouse.
large areas of fatty change liver

  
Hepatic granulomas in a mouse given dietary tetrachlorvinphos for 2 years. Note that these granulomas are comprised primarily of macrophages and multinucleated giant cells.
large areas of fatty change liver

  
Multiple granulomas are present in this Tg.AC mouse treated with rotenone.
large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

large areas of fatty change liver

  
Mouse Hepatitus Virus Infection - Click on thumbnails to view larger images
Extensive hepatic necrosis and inflammation in an athymic nude mouse with chronic mouse hepatitis virus (MHV) infection.
fatty change in liver

fatty change in liver

fatty change in liver

Mouse hepatitis virus infection in a SCID mouse. There is extensive hepatic necrosis.
fatty change in liver

fatty change in liver

fatty change in liver

periportal fatty change in liver

  

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