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Oval Cell Hyperplasia

The Digitized Atlas of Mouse Liver Lesions

Oval Cell Hyperplasia - Click on thumbnails to view larger images
Oval cell hyperplasia is typically seen in livers with multiple toxic changes as a result of treatment or infection as well as in mice treated with some hepatocarcinogens. Oval cells are small spindeloid, oval, or round cells with scant cytoplasm. They usually appear initially in periportal and subcapsular areas. It has been suggested that they are derived from terminal biliary ductular cells (Hering canal cells), and they are believed capable of differentiating into hepatocytes or biliary cells.

At low magnification, oval cell hyperplasia appears as an increased cellularity in portal areas. Slightly higher magnification reveals that centrilobular hepatocyte hypertrophy is also present.
oval cell hyperplasia
oval cell hyperplasia
 
Oval cell hyperplasia, hepatocyte hypertrophy and karyomegaly,hepatocyte degeneration, and a pseudoinclusion (protusion of cytoplasm into the nucleus) in a hepatocyte nucleus (arrow).
oval cell hyperplasia
oval cell hyperplasia
A higher magnification showing proliferation of oval cells with formation of glandular structures resembling bile ducts.
A higher magnification showing proliferation of oval cells with formation of glandular structures resembling bile ducts
  
This example of marked oval cell proliferation is showing bridging between adjacent portal areas.
example of marked oval cell proliferation is showing bridging between adjacent portal areas
example of marked oval cell proliferation is showing bridging between adjacent portal areas
 
Marked oval cell hyperplasia in an untreated male B6C3F1 mouse.
oval cell hyperplasia
oval cell hyperplasia
 
 
Sarcoma NOS (Not otherwise specified) - Click on thumbnails to view larger images.
Occasional sarcomas metastasize to the liver or, alternatively, originate there but have insufficient characteristics to permit a definitive diagnosis from H&E-stained slides. These are usually documented as sarcoma, NOS.

A discrete sarcoma of undetermined cell type is present in the liver.
sarcoma
sarcoma
 
Another example of sarcoma, NOS.
sarcoma
  
 
Ovarian Teratomas - Click on thumbnails to view larger images.
Ovarian teratomas that metastasize to the liver are uncommon in mice.

A clearly demarcated ovarian teratoma in the liver; a higher magnification shows pigmented epithelial-lined glands, glandular structures without pigment, undifferentiated epithelial cells, and mesenchymal tissue.
ovarian teratoma
ovarian teratoma
ovarian teratoma
ovarian teratoma
  
Neurological tissue is clearly present in this view.
ovarian teratoma
  

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