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Hemangioma

The Digitized Atlas of Mouse Liver Lesions

Hemangioma (Benign Hemangioendothelioma) and Hemangiosarcoma (Malignant Hemangioendothelioma) - Click on thumbnails to view larger images

Hemangiomas and hemangiosarcomas may arise as primary vascular neoplasms in the liver. They are usually not sharply demarcated from the surrounding parenchyma. Hemangiomas are recognized by a modest proliferation of a single layer of flatten, normal appearing endothelial cells lining vascular spaces with varying degrees of attendant hepatic cord atrophy.
Hemangiosarcomas may arise as primary neoplasms in the liver, as well as in other tissues. The neoplastic cells are generally elongated or spindle-shaped and may form solid areas occupying dilated hepatic sinusoids. These neoplasms are typically locally invasive.

A hemangioma has destroyed the normal hepatic parenchyma. A thrombus is present at the top of the hemangioma; high magnification shows dilated vascular channels lined by flattened endothelial cells. There is minimal atrophy of hepatic cords.

hemangiosarcoma
hemangiosarcoma

 

hemangiosarcoma

 

Dilated vascular spaces have replaced hepatic parenchyma in this hemangioma. High magnification shows dilated vascular spaces lined by flattened and sometimes dome-shaped endothelial cells and mild atrophy of the visible hepatic cords.
hemangiosarcoma
hemangiosarcoma
hemangiosarcoma
This hemangioma has isolated small clusters of hepatocytes; higher magnification shows proliferation of flattened endothelial cells.
hemangiosarcoma
hemangiosarcoma
 
This hemangiosarcoma is well demarcated from the normal hepatic parenchyma; sharp demarcation is an unusual feature of hemangiosarcomas. Large blood-filled lakes are apparent. Higher magnification shows bands of spindle-shaped endothelial cells with attendant destruction of hepatocytes, proliferation of plump endothelial cells, and atrophy of hepatocytes.
hemangiosarcoma
hemangiosarcoma
hemangiosarcoma
Another example of a hemangiosarcoma.
hemangiosarcoma
hemangiosarcoma
hemangiosarcoma
This hemangiosarcoma is poorly demarcated from surrounding parenchyma and consists of dilated blood-filled spaces and sheets of proliferating endothelial cells.
hemangiosarcoma
hemangiosarcoma
 
Hemangiosarcoma in an adult mouse.
hemangiosarcoma
hemangiosarcoma
hemangiosarcoma
This hemangiosarcoma is has caused degenerative changes in some of the entrapped hepatocytes. The degenerating hepatocytes are enlarged and vacuolated with evidence of nuclear degeneration.
hemangiosarcoma
hemangiosarcoma
hemangiosarcoma
This lesion appears consistent with early endothelial cell proliferation and peliosis but is actually at the edge of an hemangiosarcoma.
hemangiosarcoma
  
Another example of an hemangiosarcoma from a male B6C3F1 mouse.
hemangiosarcoma
hemangiosarcoma
hemangiosarcoma
 
Hepatoblastomas - Click on thumbnails to view larger images

Hepatoblastomas may be small or large lesions comprised of hyperchromatic cells with scant cytoplasm. Most appear to arise within hepatocellular carcinomas and occasionally within adenomas as well demarcated lesions. It is speculated that hepatoblastomas represent a poorly differentiated variant of hepatocellular carcinomas.

A basophilic hepatoblastoma is arising within a discrete hepatocellular adenoma.

Basophilic hepatoblastoma
  
This small hepatoblastoma is present within an hepatocellular carcinoma.
Hepatoblastoma
  
A large hepatoblastoma; higher magnification shows malignant cells palisading around vascular structures.
Hepatoblastoma
Hepatoblastoma
 
Hepatoblastoma associated with hemorrhage.
Hepatoblastoma
Hepatoblastoma
Hepatoblastoma
Hepatoblastomas and biliary cysts in the liver of an adult mouse.
Hepatoblastoma
Hepatoblastoma
Hepatoblastoma
Hepatoblastoma
  
A small hepatoblastoma within an hepatocellular carcinoma. Non-neoplastic hepatic parenchyma is present in the upper right.
Hepatoblastoma
Hepatoblastoma
Hepatoblastoma
 
Hepatocellular Adenomas - Click on thumbnails to view larger images

Hepatocellular adenomas are typically discrete proliferative lesions with loss of normal lobular architecture, absence of portal areas, and some degree of compression of adjacent normal hepatic parenchyma. The arrangement of the hepatocytes within an adenoma may be at right angles to the surrounding hepatic parenchyma. The tinctorial properties of hepatocytes within an adenoma may be basophilic, eosinophilic, pale, or mixed.

A large hepatocellular adenoma is present on the parietal surface of the left lobe.

hepatocellular adenoma
  
A discrete hepatocellular adenoma with pale staining cytoplasm.
hepatocellular adenoma
hepatocellular adenoma
hepatocellular adenoma
This adenoma has a partial rim of basophilic cells while the remaining cells are pale.
adenoma
adenoma
adenoma
adenoma
  
This mixed hepatocellular adenoma is comprised of an admixture of basophilic and pale staining hepatocytes.
 
hepatocellular adenoma
hepatocellular adenoma
hepatocellular adenoma
A discrete eosinophilic adenoma.
eosinophilic adenoma
  
A basophilic adenoma. Basophilic adenomas are often comprised of closely spaced hepatocytes with small amounts of cytoplasm.
basophilic adenoma
basophilic adenoma
basophilic adenoma
A basophilic adenoma.
basophilic adenoma
basophilic adenoma
basophilic adenoma
An eosinophilic adenoma. Note the abundant eosinophilic cytoplasm in contrast with the basophilic adenomas.
eosinophilic adenoma
eosinophilic adenoma
eosinophilic adenoma
 
Hepatocellular Carcinomas - Click on thumbnails to view larger images

Hepatocellular carcinomas may have a variety of growth patterns such as trabecular, glandular, or solid. The most common appearance is the trabecular growth pattern which consists of chords three or more cell layers thick. Hepatocellular carcinomas often have an irregular border due to local invasion into adjacent parenchyma. Areas of necrosis may be found in hepatocellular carcinomas. In some instances hepatocellular carcinomas appear to arise from within hepatocellular adenomas.

Multiple liver tumors are often produced when mice are treated with potent hepatocarcinogens. While the gross appearance of adenomas is typically dome-shaped or smoothly spherical, carcinomas have an irregular bosselated contour and prominent superficial blood vessels.

Hepatocellular Carcinoma
  
Low magnification of a hepatocellular carcinoma which is unusual in that it has a relatively discrete border; higher magnification shows irregular trabeculae and nests of neoplastic hepatocytes.
Hepatocellular Carcinoma
Hepatocellular Carcinoma
 
Hepatocellular carcinoma showing thick trabeculae.
Hepatocellular Carcinoma
  
A trabecular carcinoma is compressing adjacent hepatic parenchyma.
Hepatocellular Carcinoma
  
Hepatocellular carcinomas comprised of nests of neoplastic hepatocytes.
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular carcinoma in which some of the nests of cells have a central area of necrosis which is filled with eosinophilic material.
Hepatocellular Carcinoma
Hepatocellular Carcinoma
 
Carcinomas comprised of thickened trabeculae and nests with central necrosis.
Hepatocellular Carcinoma
  
Hepatocellular carcinoma with formation of large glands filled with eosinophilic protein material. Glandular-like structures are lined by a single layer of hepatocytes.
Hepatocellular Carcinoma
Hepatocellular Carcinoma
 
Hepatocellular carcinoma with a mixed growth pattern.
Hepatocellular Carcinoma
  
A hepatocellular carcinoma arising within a discrete hepatocellular adenoma.
Hepatocellular Carcinoma
  
A small area of carcinoma characterized by thickened trabeculae is arising within a large adenoma.
Hepatocellular Carcinoma
  
Another example of a hepatocellular carcinoma arising from within a hepatocellular adenoma.
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
 
Histiocytic Sarcoma (Kupffer Cell Sarcoma) - Click on thumbnails to view larger images

Histiocytic sarcoma (Kupffer cell sarcoma) is a multicentric neoplasm of mice that frequently involves the liver. It is uncertain whether the cells are derived from Kupffer cells or from other histiocytes. The malignant cells grow along the sinuosoids and vessels, efface the normal architecture of the hepatic lobules, and sometimes form nodules.

Spontaneous histiocytic sarcomas occur at low frequency in mice. Histiocytic sarcomas may simultaneously occur in other organs such as the spleen, lung, and uterus and are regarded as systemic neoplasms.

Histiocytic Sarcoma
Histiocytic Sarcoma
 


Extensive hepatic involvement by malignant histiocytic cells.

Histiocytic Sarcoma
Histiocytic Sarcoma
 
Low and high magnifications of a histiocytic sarcoma with a nodular growth pattern in the liver.
Histiocytic Sarcoma
Histiocytic Sarcoma
Histiocytic Sarcoma
Giant cell formation in a histiocytic sarcoma.
Histiocytic Sarcoma
  

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