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Genetics & Molecular Biology

BRENDA Comprehensive Enzyme System (http://www.brenda.uni-koeln.de/) 

Started in 1986, BRENDA contains functional data for over 3,500 different enzymes. The data collection is being developed into a metabolic network information system with links to Enzyme expression and regulation information. Comprehensive search features based on nomenclature, reaction and specificity, enzyme structure, stability, disease, sequence, and application.

 

Candidate Genes to Inherited Disease (G2D) (http://www.ogic.ca/projects/g2d_2/) 

Presents precomputed candidate genes for more than 600 genetically inherited diseases that have been mapped onto chromosomal regions without assignment of a particular gene. Search by phenotype, known gene, or chromosome/locus

 

European Bioinformatics Institute (EBI) (http://www.ebi.ac.uk/) 

The EMBL Nucleotide Sequence Database, SWISS-PROT Protein Sequence Database and other EBI databases are available through this site. An outstation of EMBL.


ExPASy (http://us.expasy.org/) 

Includes access to numerous protein databases and Sequence Analysis Tools from ExPASy.


GeneGateway (http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/) 

Collection of guides and tutorials designed to help students and other novice users get started with some of the resources that make these data available to the public.

 

Gene Ontology (http://www.geneontology.org/) 

Goal is to produce a dynamic controlled vocabulary that can be applied to all organisms, even as knowledge of gene and protein roles in cells is accumulating and changing.


Genome Gateway: The Human Genome (Nature, 409:6822) (http://www.nature.com/nature/journal/v409/n6822/index.html) 

Publications of the comprehensive sequencing and analysis of the human genome as of February, 2001. These are the seminal sites for information about the human gene map.



The Human Genome (Science, 291:5507) (http://www.nature.com/nature/journal/v409/n6822/index.html) 

Publications of the comprehensive sequencing and analysis of the human genome as of February, 2001. These are the seminal sites for information about the human gene map.



Genome Programs (http://megasun.bch.umontreal.ca/other/genomes.html) 

Links to genome sequencing projects for humans and other organisms. Produced by the Organelle Genome Megasequencing Program, a collaboration of Canadian research groups.

 

The Human Gene Map (http://www.ncbi.nlm.nih.gov/genemap/) 

The most current map resulting from the Human Genome Project.

 

Human Protein Atlas (http://www.proteinatlas.org/index.php) 

The Human Protein Atlas shows the expression and localization of proteins in a large variety of normal human tissues and cancer cells. The data is presented as high resolution images representing immunohistochemically stained tissue sections. Available proteins (genes) can be reached through a specific search (by gene/protein name/id or classification, such as kinase or protease) or by browsing the individual chromosomes

 

NCBI Genes and Disease (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gnd) 

Genes and Disease is a collection of articles that discuss genes and the diseases that they cause. These genetic disorders are organized by the parts of the body that they affect.

 

HUM-MOLGEN (Human Molecular Genetics) (http://hum-molgen.org/) 

Premier portal site on human molecular genetics. Includes news, trends in specific fields and internet resources, such as a directory of biomedical companies, journals, conferences, etc.

 

JAX Mouse Genome Informatics (http://www.informatics.jax.org/) 

Integrated access to data on the genetics, genomics and biology of the laboratory mouse.

 

Mouse Atlas Project (http://genex.hgu.mrc.ac.uk/) 

Digital atlases of mouse and human embryo development and the “Emage” database of 2D and 3D gene expression patterns during mouse embryo development.

 

National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/) 

Information center within the National Library of Medicine dealing with information on genetic research, the Human Genome Project, the ENTREZ browser, GenBank and other searchable sequence databases.


Omics Gateway (http://www.nature.com/omics/index.html) 

Omics Gateway is a portal of publications and web-based projects on large-scale "omics" biology. Search by organism or key subject areas (e.g., cancer, epigenomics, systems biology, techniques and methods, etc.).


OMIM™Online Mendelian Inheritance in Man™ (http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim) 

Comprehensive database on genetic disorders.

 

PharmGKB (http://www.pharmgkb.org/) 

This knowledge base is a central repository for genetic and clinical data to aid researchers in understanding how genetic variation among individuals contributes to differences in drug reactions. Information is arranged by gene, drug, clinical outcome, drug response, pharmacokinetics, and molecular and cellular functional assays. The data is derived from individuals participating in the Pharmacogenetics Research Network Studies.


The RCSB Protein Data Bank (http://www.rcsb.org/pdb/home/home.do) 

The Research Collaboratory for Structural Bioinformatics (RCSB) has developed the “single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data.”

 

STITCH: Chemical-Protein Interactions (http://stitch.embl.de/) 

STITCH (Search Tool for Interactions of Chemicals') integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Inferred information from phenotypic effects, text mining and chemical structure similarity is used to predict relations between chemicals. Each proposed interaction can be traced back to the original data sources. The database contains interaction information for over 68 000 different chemicals, including 2200 drugs, and connects them to 1.5 million genes across 373 genomes and their interactions contained in the STRING database.

 

Trans-NIH Mouse Initiative (http://www.nih.gov/science/models/mouse/) 

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