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B cell depletion in Idiopathic Inflammatory Myopathy

Principal Investigator:

Jo Edwards, Shabina Sultan, David Isenberg, University College, London


Study Design:

Phase 1 open, at University College, London


Types & Number of IIM Studied:

Active Polymyositis or Dermatomyositis (N = 5)


Entry Criteria:

Definite Polymyositis or Dermatomyositis by Bohan and Peter criteria; Refractory to standard therapy


IMACS Core Set Measures Included:

MITAX, Physician and Patient Global Activity Assessment, Manual Muscle Testing (MMT-8), Health Assessment Questionnaire, muscle enzymes; Health Related Quality of Life by SF-36


Other Measures Included:

Myometry, Activities of Daily Living, rash, B cells, serology


Primary Outcome:

Myometry and Creatine kinase


Study Duration:

6 months



Myositis Support Group UK



Study has completed enrollment



David A. Isenberg, M.D., F.R.C.P.
ARC Diamond Jubilee Professor of Rheumatology
University College London
Centre for Rheumatology, University College London
Arthur Stanley House
40-50 Tottenham Street
London W1P 9PG UK


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